Tear Film

1. What is the thickest layer of the tear film?

Aqueous

Mucin

Lipid

2. What layer of the tear film is in contact with glycocalyx?

Aqueous

Mucin

Lipid

3. A highly wettable material will have spread water across the tear film and have a low contact angle

True

False

4. Anteriorly to posteriorly, in what order are the layers of the tear film arranged?

Mucin, aqueous, lipid

Lipid, aqueous, mucin

Lipid, mucin, aqueous

Mucin, lipid, aqueous

Aqueous, mucin, lipid

5. A high wetting angle means that the surface does not wet well and has many dry areas

True

False

6. Non sjorgrens syndrome is local autoimmunity/inflammatory based

True

False

7. Match the sympathetc innervation of aqueous secretion receptors to their pathway

alpha-1

beta

Submit

8. Match the following

MUC54A

MUC4

MUC1

Submit

9. Reflex tears are not part of the tear film

True

False

10. Mucin is a homogenous collection of low molecular weight glycoproteins

True

False

mucin is a heterogenous collection of high molecular weight glycoproteins

Explanation

mucin is a heterogenous collection of high molecular weight glycoproteins

11. In what way do goblet cells secret mucus?

Via vesicles by calcium dependent exocytosis

Passive export

Sodium potassium ATPase

None of the above

12. What bacteria produces cholestryl esterase and fatty wax esterase and can lead to meibomian dysfunction (meibomitis) and can be treated with doxycycline?

Staphilococcous aureus

Streptococcus pneumonae

Herpes zoster

Pseudomonas aeuruginosa

13. Which of the following are mucin secretory glands? (Select 3)

Goblet cells

Crypts of Henle

Manz

Krausse

Wolfring

Submit

14. How can the secretion of mucin be blocked in regards to neural control?

Muscarinic agonist

Muscarinic antagonist

Cholinergic agonist

Cholinergic antagonist

15. Match the following glands to their location

goblet cells

crypts of henle

glands of Manz

Submit

16. 60% (most) of total proteins present in the aqueous are

Albumin

Alpha and beta globulin

Gamma globulin (like IgA)

Amino acids

17. Which phase of the mucin layer do goblet cells form?

Gel

Aqueous

Fat

Cellular

Submit

19. A surfactant does which of the following

Decrease surface tension reducing dry areas

Decrease surface tension increasing dry areas

Increase surface tension reducing dry areas

Increase surface tension increasing dry areas

20. How does mucin interact with glycocalyx

The sugar side chains from both surfaces crosslink

Hydrogen bonding of the protein backbones

Covalent bonding of the side chains

The sugar side chain of the glycocalyx cross links with the protein backbone of mucin

21. What electrolyte is greatest in amount in the serum

K+

Cl-

Na+

Ca2+

22. Which of the following is true of glycocalyx? (Select 3)

Protects against bacterial pathogens

Disruption of it can lead to dry eye

Surface atea can be increased with microvilli

Contact lenses protect this layer of proteins

Interacts with lipid layer of tear film

Submit

23. Ions enter the lumen via

Ligand-gated channels

Na+/K+ ATPase

Calcium dependent exocytosis

Passive diffusion

24. Which of the following is true of mucin? (select 3)

Provide hydrophilic surface

Provide hydrophobic surface

Decreases surface tension

Interact with trefoil factor family peptides

Increases wetting angle of cornea

Submit

25. Match the following

beta-lysin

ceruloplasmin

lactate dehydrogenase

lipocalin

GF (growth factor)

lactoferrin

lysozyme

Submit

26. Which of the following is true of lactoferrin? (select 3)

Tear specific pre-albumin

Bacteriostatic and may be bacteriolytic

Binds Fe+ ions essential to bacterial metabolism

A type of immunoglobulin

Hydrolyzes beta 1-4 glycosidic bond

Only bateriolytic

Submit

27. What is the role of P2Y2 receptor agonists in mucin release? (Select 3)

Mediates mucousal surface lubrication

Stimulate the release of mucous and other tear components

Stimulation also increases Cl- secretion by corneal epithelium

Inhibit the release of mucous and other tear components

Stimulation also decreases Cl- secretion by corneal epithelium

Submit

Tear Film

1. What is the thickest layer of the tear film?

2.

What first name or nickname would you like us to use?

2. What layer of the tear film is in contact with glycocalyx?

3. A highly wettable material will have spread water across the tear film and have a low contact angle

4. Anteriorly to posteriorly, in what order are the layers of the tear film arranged?

5. A high wetting angle means that the surface does not wet well and has many dry areas

6. Non sjorgrens syndrome is local autoimmunity/inflammatory based

7. Match the sympathetc innervation of aqueous secretion receptors to their pathway

8. Match the following

9. Reflex tears are not part of the tear film

10. Mucin is a homogenous collection of low molecular weight glycoproteins

11. In what way do goblet cells secret mucus?

12. What bacteria produces cholestryl esterase and fatty wax esterase and can lead to meibomian dysfunction (meibomitis) and can be treated with doxycycline?

13. Which of the following are mucin secretory glands? (Select 3)

14. How can the secretion of mucin be blocked in regards to neural control?

15. Match the following glands to their location

16. 60% (most) of total proteins present in the aqueous are

17. Which phase of the mucin layer do goblet cells form?

18. _____ is defined as dry mouth resulting from reduced or absent saliva flow and is associated with Sjogrens syndrome

19. A surfactant does which of the following

20. How does mucin interact with glycocalyx

21. What electrolyte is greatest in amount in the serum

22. Which of the following is true of glycocalyx? (Select 3)

23. Ions enter the lumen via

24. Which of the following is true of mucin? (select 3)

25. Match the following

26. Which of the following is true of lactoferrin? (select 3)

27. What is the role of P2Y2 receptor agonists in mucin release? (Select 3)

28. _____ is a condition where PLA2 is secreted by inflammatory cells which induces the release of histamines, prostaglandins, and erotomim causing tear film disruption.

29. Protein secretory vesicles are stored and released upon stimulation via [Blank} mediated pathways involving enzymes