M3006 End Of Course Revision Quiz

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I_stansfield

Community Contributor

Quizzes Created: 1 | Total Attempts: 218

Questions: 5 | Attempts: 218 | Updated: Mar 20, 2023

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M3006 End Of Course Revision Quiz - Quiz

Use the Figures on the MyAberdeen site revision section to help answer the questions in the quiz

Questions and Answers

1.

Take a look at Figure 2 and answer the following;The long and short-form proteins are most likely;
- A.
  
  Created by an internal ribosome entry process
- B.
  
  Created as a result of resumed scanning following translation of a uORF
- C.
  
  Created as a result of a 5'-most AUG in a poor Kozak concensus
- D.
  
  Created as a result of alternative splicing
- E.
  
  Created as a result of a 5'-most AUG codon in a good Kozak concensus, and a downstream AUG in a poor Kozak concensus
Correct Answer
C. Created as a result of a 5'-most AUG in a poor Kozak concensus

Explanation
The correct answer suggests that the long and short-form proteins are most likely created as a result of a 5'-most AUG in a poor Kozak consensus. This means that the proteins are produced from a start codon (AUG) that is located at the 5' end of the mRNA sequence and that the surrounding nucleotide sequence is not highly favorable for efficient translation initiation. This can result in the production of both long and short forms of the protein.

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2.

Take a look at Figure 2 panels A-D at the foot of the page and answer the following;Panel B represents;
- A.
  
  A protein with a secretion leader signal in the black segment
- B.
  
  A protein with a nuclear localisation signal in the second hatched segment
- C.
  
  A protein with a nuclear localisation in the black segment
- D.
  
  A protein with a KDEL signal for ER retention in the second hatched sequence
Correct Answer
C. A protein with a nuclear localisation in the black segment

Explanation
Panel B represents a protein with a nuclear localization signal in the black segment.

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3.

Take a look at Figure 2, panels A-D at the foot of the figure, and answer the following;Panel C represents;
- A.
  
  A protein carrying a mutation in its KDEL endoplasmic reticulum retention signal
- B.
  
  An endoplasmic reticulum protein with a KDEL sequence in the hatched segment
- C.
  
  A protein with a secretion leader at the N-terminus of the black segment
- D.
  
  A protein with a nuclear localisation signal in the black segment
Correct Answer
C. A protein with a secretion leader at the N-terminus of the black segment

Explanation
Panel C represents a protein with a secretion leader at the N-terminus of the black segment. This is indicated by the fact that the black segment is labeled as the N-terminus, which is the starting point of a protein sequence. The presence of a secretion leader suggests that this protein is targeted for secretion outside of the cell.

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M3006 End Of Course Revision Quiz

Take a look at Figure 2 and answer the following;The long and short-form proteins are most likely;

Take a look at Figure 2 panels A-D at the foot of the page and answer the following;Panel B represents;

Take a look at Figure 2, panels A-D at the foot of the figure, and answer the following;Panel C represents;