Micro: Toxins And Such
- 1.What codes for proteins of exotoxins?
- A.
Chromosomes
- B.
SsDNA
- C.
MRNA
- D.
Plasmids
- 2.Activation of toxins without altering antigenicity results in successful vaccines.
- A.
True
- B.
False
- 3.What toxin(s) are internalized for activation of the A subunit?
- A.
Tetanus and botulinum
- B.
Cholera and diphtheria
- C.
Staphylococcus
- D.
Diphtheria and botulinum
- 4.Diphtheria blocks the transfer of _____ _____ to polypeptide chains during ______ of mRNA by ribosomes.
- A.
Amino acids; transcrption
- B.
Adenosine diphosphate; translation
- C.
Amino acids; translation
- D.
Adenosine diphosphate; transcription
- 5.The cholera toxin inhibits the regulatory mechanism of?
- A.
ATP
- B.
CAMP
- C.
Protein kinase A
- D.
GTP
- 6.What exotoxin is active at low does and extrememly potent?
- A.
Tetanus
- B.
Cholera
- C.
Diphtheria
- D.
LPS
- 7.Tetanus affects inhibitory neurons causing continuous stimulation to motor neurons.
- A.
True
- B.
False
- 8.Botulinum toxin ____ neurotransmitter function of ____ terminals.
- A.
Inhibits; postsynaptic
- B.
Inhibits; presynaptic
- C.
Increases; postsynaptic
- D.
Increases; presynaptic
- 9.Endotoxins are only released when the cell dies.
- A.
True
- B.
False
- 10.What bacteria release LPS?
- A.
Gram positve
- B.
Streptococci
- C.
Gram negative
- D.
Staphylococci
- 11.Which best represents the composition of LPS?
- A.
Lipid B, core polysaccharide, variable O-polysaccharide
- B.
Lipid A, core monosaccharide, variable O-monosaccharide
- C.
Lipid B, core monosaccharide, variable O-monosaccharide
- D.
Lipid A, core polysaccharide, variable O-polysaccharide
- 12.What cytokines are the primary cause of fever? And they're produced by what cell?
- A.
IL-5, IL-12; eosinophils
- B.
IL-2, IL-1; T cells
- C.
IFN-gamma, TNF; macrophages
- D.
TNF, IL-1; macrophages
- 13.What structure in the brain to cytokines act on to produce fever?
- A.
Midbrain
- B.
Hypothalamus
- C.
Brainstem
- D.
Thalamus
- 14.What are the most important effects of LPS?
- A.
Fever and cell lysis
- B.
Cell lysis and shock
- C.
Fever and shock
- 15.What bacteria is the most common endotoxic shock with septicemia?
- A.
E. coli
- B.
S. aureus
- C.
Shigella
- D.
Salmonella
- 16.Toxic shock syndrome is caused by ______ infections of the _____.
- A.
Staphylococcus; intestinal
- B.
Staphylococcus; genital
- C.
Streptococcus; intestinal
- D.
Streptococcus; genital
- 17.After direct activation of completment by LPS, C3a and C5a components are produced in large quantities. This can cause aggregation of PMNs in the pulmonary capillaries resulting in a severe condtion called ____.
- A.
Acute eosinophilic pneumonia
- B.
Adult respiratory distress syndrome
- C.
Acute hypersensitivity pneumonitis
- D.
Noncardiogenic pulmonary edema
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