Medicinal Chemistry Acid-base/Prodrugs

20 Questions | By Pharmdnate | Last updated: Mar 21, 2022 | Total Attempts: 1341

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Test on Acid-Base and Prodrugs

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1.

Which of the following effect the outcome of drug molecules?
- A.
  
  Where it is aborsbed
- B.
  
  Its solubility in the stomach, plasma or in aqueous IV
- C.
  
  Compatibility with other drugs
- D.
  
  The method of delivery
- E.
  
  All of the above
2.

What do physicochemical properties of a drug molecule effect?
- A.
  
  Distribution
- B.
  
  Metabolism
- C.
  
  Excretion
- D.
  
  Toxicity
- E.
  
  All of the above
3.

What type of drug can have several PKAs
- A.
  
  Acid drugs
- B.
  
  Prodrugs
- C.
  
  Polyfunctional drugs
- D.
  
  A and B
- E.
  
  All of the above
4.

Which of the following are polyfunctional drugs?
- A.
  
  Ciprofloxacin
- B.
  
  Amoxicillin
- C.
  
  Sulfide
- D.
  
  A and B
- E.
  
  B and C
5.

As the Ph of an environment decreases the the net charge of a drug molecule will what?
- A.
  
  Increase
- B.
  
  Decrease
- C.
  
  Stay the same
- D.
  
  Cannot be determined
6.

Intramolecular hydrogen bonds may decrease solubility in what amino acid?
- A.
  
  Phenylalanine
- B.
  
  Tyrosine
- C.
  
  Alanine
- D.
  
  Gultamate
- E.
  
  Histadine
7.

What is an inactive compound transformed by chemical or metabolic means to an active product?
- A.
  
  Acid drugs
- B.
  
  Prodrugs
- C.
  
  Polyfunctional drugs
- D.
  
  A and B
- E.
  
  All of the above
8.

What is not a reason to use prodrugs?
- A.
  
  To reduce pain
- B.
  
  Atler absorption, distribution and metabolism
- C.
  
  Avoid an unpleasant taste
- D.
  
  Increase toxicity
- E.
  
  All of the above
9.

What drug is linked to a pro-moiety because of its bitter taste?
- A.
  
  Chloramphenicol
- B.
  
  Enalaprilic acid
- C.
  
  Dipivefrin HCl
- D.
  
  Clindamycin phosphate
- E.
  
  Estramustine
10.

Where is olsalazine converted into mesalamine?
- A.
  
  Colon
- B.
  
  Kidney
- C.
  
  Small intestine
- D.
  
  Liver
- E.
  
  A and B
11.

Where is menadione converted into phytonadione?
- A.
  
  Colon
- B.
  
  Kidney
- C.
  
  Small intestine
- D.
  
  Liver
- E.
  
  All of the above
12.

Which of the following is an ACE inhibitor and poorly absorbed?
- A.
  
  Chloramphenicol
- B.
  
  Enalaprillic acid
- C.
  
  Dipivefrin HCl
- D.
  
  Aminosalicylic acid
- E.
  
  Mesalamine
13.

Which of the following is not a esterase that generates active drugs?
- A.
  
  Azo reductase
- B.
  
  Acetylcholinesterase
- C.
  
  Lipase
- D.
  
  Cholinesterase
- E.
  
  All of the above
14.

What drug is used to avoid pain at the point of injection during parenteral administration?
- A.
  
  Chloramphenicol
- B.
  
  Enalaprilic acid
- C.
  
  Dipivefrin HCl
- D.
  
  Clindamycin phosphate
- E.
  
  Estramustine
15.

What is the prodrug of epinephrine?
- A.
  
  Chloramphenicol
- B.
  
  Enalaprilic acid
- C.
  
  Dipivefrin HCl
- D.
  
  Clindamycin phosphate
- E.
  
  Mesalamine
16.

What converts Protonsil into Sulfanilamide?
- A.
  
  Azo reductase
- B.
  
  Esterase
- C.
  
  Viral thymindine kinase
- D.
  
  Glucosidase
- E.
  
  All of the above
17.

Which of the following is used to treat ulcerative colitis?
- A.
  
  Aminosalicylic acid
- B.
  
  Menadione
- C.
  
  Mesalamine
- D.
  
  A and C
- E.
  
  A and B
18.

Which of the following is used for prostate cancer?
- A.
  
  Chloramphenicol
- B.
  
  Enalaprilic acid
- C.
  
  Dipivefrin HCl
- D.
  
  Aminosalicylic acid
- E.
  
  Estramustine
19.

What can dopamine be derived from?
- A.
  
  L-dopa
- B.
  
  Dihydropyridine prodrug
- C.
  
  Enalaprilic acid
- D.
  
  A and B
- E.
  
  A and C
20.

What enzyme activates Idoxuridine?
- A.
  
  Azo reductase
- B.
  
  Esterase
- C.
  
  Viral thymidine kinase
- D.
  
  Glucosidase
- E.
  
  All of the above