Medicinal Chemistry Acid-base/Prodrugs

20 Questions | Total Attempts: 1341

SettingsSettingsSettings
Medicinal Chemistry Quizzes & Trivia

Test on Acid-Base and Prodrugs


Questions and Answers
  • 1. 
    Which of the following effect the outcome of drug molecules?
    • A. 

      Where it is aborsbed

    • B. 

      Its solubility in the stomach, plasma or in aqueous IV

    • C. 

      Compatibility with other drugs

    • D. 

      The method of delivery

    • E. 

      All of the above

  • 2. 
    What do physicochemical properties of a drug molecule effect?
    • A. 

      Distribution

    • B. 

      Metabolism

    • C. 

      Excretion

    • D. 

      Toxicity

    • E. 

      All of the above

  • 3. 
    What type of drug can have several PKAs
    • A. 

      Acid drugs

    • B. 

      Prodrugs

    • C. 

      Polyfunctional drugs

    • D. 

      A and B

    • E. 

      All of the above

  • 4. 
    Which of the following are polyfunctional drugs?
    • A. 

      Ciprofloxacin

    • B. 

      Amoxicillin

    • C. 

      Sulfide

    • D. 

      A and B

    • E. 

      B and C

  • 5. 
    As the Ph of an environment decreases the the net charge of a drug molecule will what?
    • A. 

      Increase

    • B. 

      Decrease

    • C. 

      Stay the same

    • D. 

      Cannot be determined

  • 6. 
    Intramolecular hydrogen bonds may decrease solubility in what amino acid?
    • A. 

      Phenylalanine

    • B. 

      Tyrosine

    • C. 

      Alanine

    • D. 

      Gultamate

    • E. 

      Histadine

  • 7. 
    What is an inactive compound transformed by chemical or metabolic means to an active product?
    • A. 

      Acid drugs

    • B. 

      Prodrugs

    • C. 

      Polyfunctional drugs

    • D. 

      A and B

    • E. 

      All of the above

  • 8. 
    What is not a reason to use prodrugs?
    • A. 

      To reduce pain

    • B. 

      Atler absorption, distribution and metabolism

    • C. 

      Avoid an unpleasant taste

    • D. 

      Increase toxicity

    • E. 

      All of the above

  • 9. 
    What drug is linked to a pro-moiety because of its bitter taste?
    • A. 

      Chloramphenicol

    • B. 

      Enalaprilic acid

    • C. 

      Dipivefrin HCl

    • D. 

      Clindamycin phosphate

    • E. 

      Estramustine

  • 10. 
    Where is olsalazine converted into mesalamine?
    • A. 

      Colon

    • B. 

      Kidney

    • C. 

      Small intestine

    • D. 

      Liver

    • E. 

      A and B

  • 11. 
    Where is menadione converted into phytonadione?
    • A. 

      Colon

    • B. 

      Kidney

    • C. 

      Small intestine

    • D. 

      Liver

    • E. 

      All of the above

  • 12. 
    Which of the following is an ACE inhibitor and poorly absorbed?
    • A. 

      Chloramphenicol

    • B. 

      Enalaprillic acid

    • C. 

      Dipivefrin HCl

    • D. 

      Aminosalicylic acid

    • E. 

      Mesalamine

  • 13. 
    Which of the following is not a esterase that generates active drugs?
    • A. 

      Azo reductase

    • B. 

      Acetylcholinesterase

    • C. 

      Lipase

    • D. 

      Cholinesterase

    • E. 

      All of the above

  • 14. 
    What drug is used to avoid pain at the point of injection during parenteral administration?
    • A. 

      Chloramphenicol

    • B. 

      Enalaprilic acid

    • C. 

      Dipivefrin HCl

    • D. 

      Clindamycin phosphate

    • E. 

      Estramustine

  • 15. 
    What is the prodrug of epinephrine?
    • A. 

      Chloramphenicol

    • B. 

      Enalaprilic acid

    • C. 

      Dipivefrin HCl

    • D. 

      Clindamycin phosphate

    • E. 

      Mesalamine

  • 16. 
    What converts Protonsil into Sulfanilamide?
    • A. 

      Azo reductase

    • B. 

      Esterase

    • C. 

      Viral thymindine kinase

    • D. 

      Glucosidase

    • E. 

      All of the above

  • 17. 
    Which of the following is used to treat ulcerative colitis?
    • A. 

      Aminosalicylic acid

    • B. 

      Menadione

    • C. 

      Mesalamine

    • D. 

      A and C

    • E. 

      A and B

  • 18. 
    Which of the following is used for prostate cancer?
    • A. 

      Chloramphenicol

    • B. 

      Enalaprilic acid

    • C. 

      Dipivefrin HCl

    • D. 

      Aminosalicylic acid

    • E. 

      Estramustine

  • 19. 
    What can dopamine be derived from?
    • A. 

      L-dopa

    • B. 

      Dihydropyridine prodrug

    • C. 

      Enalaprilic acid

    • D. 

      A and B

    • E. 

      A and C

  • 20. 
    What enzyme activates Idoxuridine?
    • A. 

      Azo reductase

    • B. 

      Esterase

    • C. 

      Viral thymidine kinase

    • D. 

      Glucosidase

    • E. 

      All of the above

Back to Top Back to top