Medicinal Chemistry Acid-base/Prodrugs
Test on Acid-Base and Prodrugs
- 1.Which of the following effect the outcome of drug molecules?
- A.
Where it is aborsbed
- B.
Its solubility in the stomach, plasma or in aqueous IV
- C.
Compatibility with other drugs
- D.
The method of delivery
- E.
All of the above
- 2.What do physicochemical properties of a drug molecule effect?
- A.
Distribution
- B.
Metabolism
- C.
Excretion
- D.
Toxicity
- E.
All of the above
- 3.What type of drug can have several PKAs
- A.
Acid drugs
- B.
Prodrugs
- C.
Polyfunctional drugs
- D.
A and B
- E.
All of the above
- 4.Which of the following are polyfunctional drugs?
- A.
Ciprofloxacin
- B.
Amoxicillin
- C.
Sulfide
- D.
A and B
- E.
B and C
- 5.As the Ph of an environment decreases the the net charge of a drug molecule will what?
- A.
Increase
- B.
Decrease
- C.
Stay the same
- D.
Cannot be determined
- 6.Intramolecular hydrogen bonds may decrease solubility in what amino acid?
- A.
Phenylalanine
- B.
Tyrosine
- C.
Alanine
- D.
Gultamate
- E.
Histadine
- 7.What is an inactive compound transformed by chemical or metabolic means to an active product?
- A.
Acid drugs
- B.
Prodrugs
- C.
Polyfunctional drugs
- D.
A and B
- E.
All of the above
- 8.What is not a reason to use prodrugs?
- A.
To reduce pain
- B.
Atler absorption, distribution and metabolism
- C.
Avoid an unpleasant taste
- D.
Increase toxicity
- E.
All of the above
- 9.What drug is linked to a pro-moiety because of its bitter taste?
- A.
Chloramphenicol
- B.
Enalaprilic acid
- C.
Dipivefrin HCl
- D.
Clindamycin phosphate
- E.
Estramustine
- 10.Where is olsalazine converted into mesalamine?
- A.
Colon
- B.
Kidney
- C.
Small intestine
- D.
Liver
- E.
A and B
- 11.Where is menadione converted into phytonadione?
- A.
Colon
- B.
Kidney
- C.
Small intestine
- D.
Liver
- E.
All of the above
- 12.Which of the following is an ACE inhibitor and poorly absorbed?
- A.
Chloramphenicol
- B.
Enalaprillic acid
- C.
Dipivefrin HCl
- D.
Aminosalicylic acid
- E.
Mesalamine
- 13.Which of the following is not a esterase that generates active drugs?
- A.
Azo reductase
- B.
Acetylcholinesterase
- C.
Lipase
- D.
Cholinesterase
- E.
All of the above
- 14.What drug is used to avoid pain at the point of injection during parenteral administration?
- A.
Chloramphenicol
- B.
Enalaprilic acid
- C.
Dipivefrin HCl
- D.
Clindamycin phosphate
- E.
Estramustine
- 15.What is the prodrug of epinephrine?
- A.
Chloramphenicol
- B.
Enalaprilic acid
- C.
Dipivefrin HCl
- D.
Clindamycin phosphate
- E.
Mesalamine
- 16.What converts Protonsil into Sulfanilamide?
- A.
Azo reductase
- B.
Esterase
- C.
Viral thymindine kinase
- D.
Glucosidase
- E.
All of the above
- 17.Which of the following is used to treat ulcerative colitis?
- A.
Aminosalicylic acid
- B.
Menadione
- C.
Mesalamine
- D.
A and C
- E.
A and B
- 18.Which of the following is used for prostate cancer?
- A.
Chloramphenicol
- B.
Enalaprilic acid
- C.
Dipivefrin HCl
- D.
Aminosalicylic acid
- E.
Estramustine
- 19.What can dopamine be derived from?
- A.
L-dopa
- B.
Dihydropyridine prodrug
- C.
Enalaprilic acid
- D.
A and B
- E.
A and C
- 20.What enzyme activates Idoxuridine?
- A.
Azo reductase
- B.
Esterase
- C.
Viral thymidine kinase
- D.
Glucosidase
- E.
All of the above
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