Mdcm - Nsaids - Quiz & Trivia

1. Metabolism of ibuprofen involves the i-bu chain oxidation.

True

False

2. PGE2 and PGF2α biosynthesis is greatly increased hours before child birth.

True

False

3. Celebrex is approved for RA, OA, acute pain, and FAP.

True

False

4. BRMs and DMARDs can lead to serious infection.

True

False

5. Aspirin can prevent colon cancer by preventing polyp formation.

True

False

6. Diflunisal is 4 to 5x more potent than ASA, has neglible antipyretic effects, and has less GI side effects.

True

False

7.

Nabumetone's reduced GI side effects is probably due to its COX-2 selectivity and the fact that it has no acidic functional group.

True

False

8. Ketorolac is as effective as the opioids in the short term treatment of moderate to severe postoperative pain.

True

False

9. Which enzyme is inducible?

Cox-1

Cox-2

10. Aspirin acetylates what enzyme?

Thromboxane synthetase

Prostacycline synthetase

11. Which is is involved with platelet aggregation inhibition, vasodilation, and protecting the stomach?

TXA2

PGG2

PGE2

PGH2

12. Which enzyme is found in platelets?

COX-1

COX-2

13. Diclofenac undergoes extensive ______ metabolism.

Renal

Hepatic

14. Ketorolac was the first parenteral NSAID.

True

False

15. TXA2 has a half life of 30 seconds.

True

False

16. Unlike Aspirin, Salsalate does not inhibit thromboxane synthetase (does not acetylate), therefore, it has no effect on platelet function.

True

False

17. Naproxen is the top NSAID.

True

False

18. Which drug is a chimeric human/mouse anti-TNF monoclonal antibody?

Adalimmumab (Humira)

Infliximab (Remicade)

Golimumab (Simponi)

Certolizumab (Cimzia)

19. All NSAIDs can cause CNS effects such as dizziness, anxiety, and headaches. Which of the following NSAIDs may cause severe CNS effects?

Indomethacin

Naproxen

Tolmentin

Diflunisal

20. This drug is available as a gel or vaginal suppository and is used to increase the frequency and amplitutde of uterine contractions. Its onset is 10 minutes and a side effect is cramping.

Misoprostol

Alprostadil (PGE1)

Dinoprostone (PGE2)

21. Naproxen's half life is ___ hours.

3

13

23

22. NSAIDs increase uterine motility.

True

False

inhibit uterine motility

Explanation

inhibit uterine motility

23. Which useful group of NSAIDs is also known as "profens?" They are potent anti-inflammatory drugs because of the addition of a methyl group.

Arylacetic acid

Pyrroleacetic acid

Arylpropionic acid

24. Sulindac undergoes in vivo _______ to form the sulfide form, the active drug,

Oxidation

Reduction

25.

Piroxicam undergoes what kind of metabolism?

O-demethylation

Hydroxylation of pyridine ring (5')

Oxidation

Phenyl ether cleavage

26. NSAIDs _________ gestation.

Shorten

Prolong

27. NSAIDs have the most rapid onset of action. Between DMARDs and BRMs, which acts more quickly?

DMARDs

BRMs

Submit

29. Piroxicam has less severe GI side effects than meloxicam.

True

False

it's the other way around

Explanation

it's the other way around

Submit

31. The aliphatic residue of this molecule is of smaller size and creates a side pocket.

COX-1

COX-2

32. Which drug is available as an opthalmic solution and topical gel?

Ibuprofen

Aspirin

Diclofenac

Indomethacin

Salsalate

33. Which of the following is true regarding Meloxicam? Select all that apply.

It is 10 fold more selective for COX-2 than COX-1

It is dosed twice daily

It is part of an enolic class of NSAIDs

Submit

34.

Metabolism of this drug primarily includes...

Oxidation

Glucuronidation

O-demethylation

35. Which was the first BRM on the market? It is a recombinant form of soluble human TNF receptor and is injected sub-q once to twice weekly.

Infliximab (Remicade)

Adalimmumab (Humira)

Etanercept (Enbrel)

36. DMARDs include which of the following? Select all that apply.

Gold compounds

Immunosupressants

Anticancer agents

Antimalarials

Submit

37. Which is involved in vasoconstriction, platelet aggregation, and bronchoconstriction...

Prostacylins

Prostaglandins

Leukotrienes

Thromboxanes

38. Which of the following drugs are pro-drugs? Select all that apply.

Sulindac

Diclofenac

Nabumetone

Indomethacin

Submit

40.

Diclofenac undergoes HYDROXYLATION at which position?

1

2

3

4

5

6

7

41. Which of the following is a PEGylated drug?

Adalimmumab (Humira)

Infliximab (Remicade)

Golimumab (Simponi)

Certolizumab (Cimzia)

42. PGG2 and PGH2 are associated with what? Select all that apply.

Vasoconstriction

Vasodilation

Platelet aggregation

Platelet aggregation inhibitor

Pain

Protects stomach

Bronchoconstriction

Submit

43. Which of the following is true regarding COX-3? Select all that apply.

Involved in pain

Involved in fever

Involved in inflammation

Inhibited by acetaminophen

Inhibited by aspirin

Inhibited by DMARDs

Submit

44. How does PGE2 help the stomach? Select all that apply.

Inhibits gastric acid secretion

Stimulates secretion of mucous

Stimulates secretion of bicarb

Submit

45. Which DMARDs are used in mild cases of RA? Select all that apply.

Hydroxychloroquine

Methotrexate

Sulfasalazine

Submit

46. Which NSAID is the least renal toxic?

Piroxicam

Meloxicam

Ibuprofen

Indomethacin

Sulindac

Diclofenac

47.

Aspirin's major metabolic pathway occurs when this occurs. Also, what percent of an ASA dose is excreted as salicylic acid?

Oxidation, 1%

Oxidation, 10%

Oxidation, 20%

When glycine complexes with the COOH, 1%

When glycine complexes with the COOH, 10%

When glycine complexes with the COOH, 20%

Glucuronidation, 1%

Glucuronidation, 10%

Glucuronidation, 20%

48. What is used for the harvest and storage of platelets in renal dialysis and cardiopulmonary bypass?

Thromboxanes

Prostacyclins

Prostaglandins

Leukotrienes

49. Diflunisal is effective as an antipyretic.

True

False

50. Which of the following is true regarding ASA? Select all that apply.

Potency: COX-1 > COX-2

Rapidly hydrolyzed by plasma esterases

Stable in solution

Prevents colon polyp formation

The COOH has a direct corrosive effect in causing ulceration

Oral bioavailability is 80 to 100%

Short half life

Submit

51. Which of the following is true regarding Ibuprofen? Select all that apply.

Sold as racemate. S-enantiomer is more active in vitro (but R-enantioner covered to S-enantiomer in vivo)

Metabolism involves I-bu chain oxidation

First member of its class (arylpropionic acids)

Better tolerated then ASA or Indomethacin

Submit

52.

Which of the following is true regarding this NSAID? Select all that apply.

Antipyretic, analgesic, and anti-inflammatory

Causes less GI upset than ASA

Available as oral liquid

Inhibits thromboxane synthetase

COX inhibitor (irreversible)

Submit

53. Which of the following can safely be taken with methotrexate? Select all that apply.

NSAIDs

Celebrex

BRMs

Submit

54. Which of the following drugs have no appreciable effect on platelets? Select all that apply.

Diflunisal

Salsalate

Piroxicam

Celebrex

Choline salicylate

Aspirin

Sodium salicylate

Fenoprofen

Naproxen

Submit