Quiz: Test Your Knowledge About Organic Nitrates
11 Questions
| Attempts: 122
How well do you know Organic Nitrates? Organic nitrates are nitric acid esters of mono- and polyhydric alcohols. They have a blood pressure lowing effect which makes them adequate for a variety of medications. To see how much you already know about organic nitrates, and learn interesting trivia, take this quiz.
Questions and Answers
- 1.Which class of drugs are converted to nitric oxide (NO) which stimulates guanylate cyclase to cause an increase in formaiton of cyclic GMP, which dephosphorylates mysoin light chains and causes vascular relaxation?
- 2.Organic nitrates cause vascular relaxation which results in dilation. Which predominates? Dilation of veins or of arteries?
- A.
Veins
- B.
Arteries
- 3.Do the organic nitrates directly alter the inotropic (force of contraction) or chronotropic (rate) state of the heart?
- A.
Yes
- B.
No
- 4.Which drug class cause a marked reduction in myocardial work and thus a reduction in oxygen demand?
- 5.Which of the organic nitrate drugs is an inhalant?
- A.
Nitroglycerin
- B.
Amyl Nitrate
- C.
Isosorbide dinitrate
- D.
Isosorbide mononitrite
- 6.Which of the organic nitrate drugs is used sublingually for acute attacks?
- A.
Amyl nitrate
- B.
Nitroglycerin
- C.
Isosorbide dinitrate
- D.
Isosorbide mononitrate
- 7.The biotransformation of organic nitrates is the result of reductive hydrolysis catalyzed by the hepatic enzyme glutathione-organic nitrate reductase.
- A.
True
- B.
False
- 8.Which route of administration of organic nitrates is most useful for the treatment of acute attacks of angina pectoris?
- 9.Which route/routes of administration are used prophylactically to prevent angina?
- A.
Sublingual
- B.
Oral
- C.
Transdermal
- 10.Which of the organic nitrate drugs are used prophylactically to prevent anginas?
- A.
Nitroglycerin
- B.
Amyl nitrate
- C.
Isosorbide di/mononitrate
- 11.Which of the acute adverse effects of organic nitrates is unique?
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