Test Your Knowledge About Organic Nitrates
How well do you know Organic Nitrates? Organic nitrates are nitric acid esters of mono- and polyhydric alcohols. They have a blood pressure lowing effect which makes them adequate for a variety of medications. To see how much you already know about organic nitrates, and learn interesting trivia, take this quiz.
Questions and Answers
- 1.
Which class of drugs are converted to nitric oxide (NO) which stimulates guanylate cyclase to cause an increase in formaiton of cyclic GMP, which dephosphorylates mysoin light chains and causes vascular relaxation?
Correct Answer
Organic NitratesExplanation
Organic nitrates are a class of drugs that are converted to nitric oxide (NO) in the body. Nitric oxide then stimulates guanylate cyclase, an enzyme that increases the formation of cyclic GMP. Cyclic GMP, in turn, dephosphorylates myosin light chains, leading to vascular relaxation. Therefore, organic nitrates are responsible for this process and are the correct answer.Rate this question:
- 2.
Organic nitrates cause vascular relaxation which results in dilation. Which predominates? Dilation of veins or of arteries?
- A.
Veins
- B.
Arteries
Correct Answer
A. VeinsExplanation
Organic nitrates cause vascular relaxation, leading to dilation of blood vessels. In this case, the question asks which type of blood vessel, veins or arteries, experiences a greater degree of dilation. The correct answer is veins. This is because veins have thinner walls and are more compliant compared to arteries. As a result, they are more responsive to the vasodilatory effects of organic nitrates, leading to a greater dilation of veins compared to arteries.Rate this question:
-
- 3.
Do the organic nitrates directly alter the inotropic (force of contraction) or chronotropic (rate) state of the heart?
- A.
Yes
- B.
No
Correct Answer
B. NoExplanation
Organic nitrates do not directly alter the inotropic or chronotropic state of the heart. Instead, they work by being converted into nitric oxide, which then activates guanylate cyclase and leads to the production of cyclic guanosine monophosphate (cGMP). cGMP causes smooth muscle relaxation, including in the coronary arteries, leading to vasodilation and increased blood flow to the heart. This increased blood flow can indirectly affect the inotropic and chronotropic state of the heart, but the nitrates themselves do not directly alter these parameters.Rate this question:
-
- 4.
Which drug class cause a marked reduction in myocardial work and thus a reduction in oxygen demand?
Correct Answer
Organic NitratesExplanation
Organic nitrates are known to cause a marked reduction in myocardial work and a subsequent reduction in oxygen demand. These drugs work by dilating the blood vessels, particularly the veins, which leads to decreased preload and thus less work for the heart. This decrease in myocardial work reduces the demand for oxygen, making organic nitrates effective in treating conditions such as angina.Rate this question:
- 5.
Which of the organic nitrate drugs is an inhalant?
- A.
Nitroglycerin
- B.
Amyl Nitrate
- C.
Isosorbide dinitrate
- D.
Isosorbide mononitrite
Correct Answer
B. Amyl NitrateExplanation
Amyl Nitrate is an inhalant organic nitrate drug. It is commonly used as a vasodilator to treat certain heart conditions, such as angina. When inhaled, amyl nitrate quickly enters the bloodstream and relaxes the blood vessels, allowing for increased blood flow and reduced chest pain. This drug is often used in emergency situations to relieve angina attacks. Nitroglycerin, Isosorbide dinitrate, and Isosorbide mononitrite are also organic nitrate drugs, but they are typically administered orally or topically rather than through inhalation.Rate this question:
-
- 6.
Which of the organic nitrate drugs is used sublingually for acute attacks?
- A.
Amyl nitrate
- B.
Nitroglycerin
- C.
Isosorbide dinitrate
- D.
Isosorbide mononitrate
Correct Answer
B. NitroglycerinExplanation
Nitroglycerin is used sublingually for acute attacks. It is an organic nitrate drug that works by relaxing and widening blood vessels, which helps to improve blood flow and relieve symptoms of angina. Sublingual administration allows for rapid absorption of the medication into the bloodstream, providing quick relief during acute attacks. Amyl nitrate, isosorbide dinitrate, and isosorbide mononitrate are also organic nitrate drugs, but they are typically used in different forms or for different purposes.Rate this question:
-
- 7.
The biotransformation of organic nitrates is the result of reductive hydrolysis catalyzed by the hepatic enzyme glutathione-organic nitrate reductase.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
The statement is explaining that the biotransformation of organic nitrates occurs through reductive hydrolysis, which is catalyzed by the hepatic enzyme glutathione-organic nitrate reductase. This means that the organic nitrates are broken down into simpler components with the help of the enzyme. Therefore, the statement is true.Rate this question:
-
- 8.
Which route of administration of organic nitrates is most useful for the treatment of acute attacks of angina pectoris?
Correct Answer
SublingualExplanation
Sublingual administration of organic nitrates is the most useful route for treating acute attacks of angina pectoris because it allows for rapid absorption of the medication through the rich blood supply under the tongue. This method bypasses the digestive system and allows the medication to enter the bloodstream quickly, providing fast relief for the patient.Rate this question:
- 9.
Which route/routes of administration are used prophylactically to prevent angina?
- A.
Sublingual
- B.
Oral
- C.
Transdermal
Correct Answer(s)
B. Oral
C. TransdermalExplanation
Oral and transdermal routes of administration are used prophylactically to prevent angina. The oral route involves taking medications by mouth, which then enter the bloodstream and are distributed throughout the body. This allows for sustained and systemic effects. The transdermal route involves applying medications to the skin, where they are absorbed and enter the bloodstream. Transdermal administration provides a controlled release of medication over an extended period of time, ensuring a steady and continuous therapeutic effect. Both routes offer convenient and effective options for long-term angina prevention.Rate this question:
-
- 10.
Which of the organic nitrate drugs are used prophylactically to prevent anginas?
- A.
Nitroglycerin
- B.
Amyl nitrate
- C.
Isosorbide di/mononitrate
Correct Answer
C. Isosorbide di/mononitrateExplanation
Isosorbide di/mononitrate is used prophylactically to prevent anginas. It belongs to the class of organic nitrate drugs and works by dilating the blood vessels, reducing the workload on the heart, and improving blood flow to the heart. This helps to prevent angina attacks and relieve symptoms of chest pain. Nitroglycerin and amyl nitrate are also organic nitrate drugs, but they are typically used for acute treatment of angina attacks rather than for prophylaxis.Rate this question:
-
- 11.
Which of the acute adverse effects of organic nitrates is unique?
Correct Answer
Reflex tachycardiaExplanation
Reflex tachycardia is the only acute adverse effect of organic nitrates that is considered unique. Organic nitrates are commonly used to treat angina and work by dilating blood vessels, which can lead to a decrease in blood pressure. However, this decrease in blood pressure can trigger a compensatory response in the body, causing the heart rate to increase in order to maintain adequate blood flow. This phenomenon is known as reflex tachycardia and is not seen with other adverse effects of organic nitrates, making it unique.Rate this question:
Quiz Review Timeline +
Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.
-
Current Version
-
Nov 16, 2023Quiz Edited by
ProProfs Editorial Team -
Dec 14, 2010Quiz Created by
Lms45808
Back to top