What Do You Know About Respiratory Failure? Trivia Questions

2.

A 64-year-old man with moderate chronic obstructive pulmonary disease presents to your office complaining that for the past 5 days, he has been experiencing worsening shortness of breath. He denies having fevers or chills, but he does report increasing purulent sputum production. He visited his 6-year-old grandson this past weekend, and the child had symptoms of an upper respiratory infection. The patient's vital signs are normal except that oxygen saturation on room air is 88%. Examination reveals bilateral expiratory wheezing. A chest radiograph is normal. Results of laboratory testing are as follows: white blood cell count, 12,500/mm3; arterial blood gas pH, 7.35; arterial oxygen tension (PaO2), 65 mm Hg; and carbon dioxide tension (PCO2), 60 mm Hg. You arrange for the hospital admission. Which of the following is the most appropriate step to take next for this patient after he is admitted to the hospital?

Mechanical ventilation
Noninvasive positive-pressure ventilation
Supplemental oxygenation via nasal cannula
Continuous oxygen saturation monitoring

Correct Answer

A. Supplemental oxygenation via nasal cannula

Explanation

Acute hypercapnic respiratory failure is defined as an arterial carbon dioxide tension (PaCO2) greater than 45 to 50 mm Hg, in association with respiratory acidosis. Chronic failure is also marked by an elevation in arterial carbon dioxide tension (PaCO2), but in patients with chronic respiratory failure, renal compensation tends to normalize the pH. The distinction between acute and chronic hypercapnic respiratory failure is important because the two have different prognoses and therapeutic implications. Signs and symptoms of hypercapnia depend not only on the absolute level of PaCO2 but also on the rate at which the level increases. A PaCO2 higher than 100 mm Hg may be well tolerated if the hypercapnia develops slowly and acidemia is minimized by renal compensatory changes. However, acute increases in PaCO2 levels may produce many neurologic symptoms and signs, including confusion, headaches, seizures, and coma. Nasal cannulas allow patients to eat, drink, and speak during oxygen administration. The disadvantage is that the exact fraction of inspired oxygen (FIO2) that is delivered is not known, because FIO2 is influenced by peak inspiratory flow demand. Noninvasive positive pressure ventilation is not indicated for patients with cardiac or respiratory arrest; nonrespiratory organ failure; impaired consciousness; unstable cardiac rhythms; hemodynamic instability; severe upper gastrointestinal bleeding; inability to protect the upper airway or clear secretions; or facial surgery, trauma or deformity. When adequate oxygenation cannot be obtained by noninvasive means or if progressive hypoventilation and hypercapnia with respiratory acidosis occur, endotracheal intubation and mechanical ventilatory support should be initiated.

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3.

An 82-year-old woman is brought to your clinic by her family. They report that the patient has been increasingly confused for the past few days. She is lethargic and barely arousable. The patient has stage IV breast cancer with widespread bony metastases and requires long- and short-acting narcotics for pain control. Her daughter reports that the patient has been taking increasing doses of her long-acting morphine to control the pain. Results of physical examination are as follows: blood pressure, 98/62 mm Hg; heart rate, 63 beats/min; respiratory rate, 8 breaths/min; temperature, 98.2Ã?Â° F (36.8Ã?Â° C); and oxygen saturation on room air, 95%. Arterial blood gas measurement reveals an acute respiratory acidosis. Because of the patient's altered mental status and the inability to protect her airway, the patient is admitted to the intensive care unit for mechanical ventilation. Which of the following conditions would place this patient at risk for acute hypercapnic respiratory failure?

Guillain-Barre syndrome
Acute respiratory distress syndrome
Large pulmonary embolism
Pulmonary edema

Correct Answer

A. Guillain-Barre syndrome

Explanation

Guillain-Barre syndrome: Guillain-Barre syndrome is a peripheral nervous system disorder that affects nerve function and can lead to muscle weakness or paralysis. While respiratory muscle weakness can occur in Guillain-Barre syndrome, it is not typically associated with acute hypercapnic respiratory failure unless severe respiratory muscle involvement leads to respiratory failure.
Acute respiratory distress syndrome (ARDS): ARDS is a severe lung condition characterized by inflammation and injury to the lungs, leading to impaired gas exchange and severe hypoxemia. While ARDS can lead to respiratory failure, it typically presents with hypoxemic respiratory failure rather than hypercapnic respiratory failure.
Large pulmonary embolism: A large pulmonary embolism can cause acute respiratory distress and hypoxemia due to obstruction of pulmonary blood flow. However, it is not typically associated with acute hypercapnic respiratory failure unless there are significant underlying lung disease or comorbidities contributing to hypoventilation.
Pulmonary edema: Pulmonary edema is the accumulation of fluid in the lungs, often due to heart failure or acute respiratory distress. While severe pulmonary edema can cause respiratory distress and hypoxemia, it is not typically associated with acute hypercapnic respiratory failure unless there are underlying lung disease or comorbidities contributing to hypoventilation.
Given the patient's history of stage IV breast cancer with widespread bony metastases and long-acting morphine use for pain control, the most likely condition placing her at risk for acute hypercapnic respiratory failure is Guillain-Barre syndrome.

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4.

A 38-year-old woman with severe asthma presents to your clinic complaining that for the past 2 days, she has been experiencing progressive shortness of breath. She now experiences shortness of breath while at rest. She reports little relief of her symptoms with the use of her albuterol inhaler. She says that she is feeling tired. On examination, the patient's respiratory rate is 18 breaths/min; oxygen saturation on room air is 86%. She has few expiratory wheezes with very little air movement. Results of arterial blood gas measurements are as follows: pH, 7.2; PaO2, 62 mm Hg; and PCO2, 63 mm Hg. On the basis of the arterial blood gas measurements, which of the following best describes this patient's condition?

Acute hypoxemic respiratory failure
Acute hypercarbic respiratory failure
Chronic hypercarbic respiratory failure
Mixed hypoxemic and hypercarbic respiratory failure

Correct Answer

A. Mixed hypoxemic and hypercarbic respiratory failure

Explanation

Respiratory failure is defined as the inability of the respiratory system to provide an adequate gas exchange to meet the requirements of the individual patient. This can take the form of inadequate oxygenation of the arterial blood, the inability to remove sufficient CO2 from the blood (impaired ventilation), or a combination of both processes. Acute respiratory failure can result from lesions affecting several parts of the respiratory pump. Understanding the respiratory pump allows the clinician to classify any perturbation in the system on the basis of pathophysiology and helps the clinician narrow the differential diagnosis and decide on appropriate clinical management. Hypoxemic respiratory failure is a consequence of gas exchange failure and is recognized by hypoxemia (PaO2 < 60 mm Hg) with or without an increase in the alveolar-arterial O2 gradient. Hypercapnic respiratory failure is a consequence of ventilatory failure and is recognized by an elevation in PaCO2 (> 45 mm Hg at sea level).

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5.

A 29-year-old woman presents to your office complaining of shortness of breath. She has no medical problems and takes no medications. She reports recently flying home from a trip to Japan. Her vital signs are as follows: blood pressure, 105/70 mm Hg; heart rate, 82 beats/min; respiratory rate, 18 breaths/min; and temperature, 98.6° F (37° C). The results of cardiac and pulmonary examinations are normal. A chest radiograph is unremarkable. Before ordering a spiral CT of the chest, you measure arterial blood gas on room air to evaluate the patient's alveolar-arterial difference in oxygen (A-aDO2). What is the normal value for A-aDO2?

< 5 mm Hg
5 to 10 mm Hg
10 to 15 mm Hg
15 to 20 mm Hg
> 20 mm Hg

Correct Answer

A. 5 to 10 mm Hg

Explanation

A clinical approach to hypoxemic respiratory failure requires the differentiation of potential causes on the basis of the alveolar gas equation and the A-aDO2. The value is influenced by age; it increases by 3 mm Hg every decade after 30 years of age. Hypoxemic respiratory failure with a normal A-aDO2 is caused by a low inspired oxygen concentration or alveolar hypoventilation. V/Q mismatching, shunt pathophysiology, or a diffusion abnormality will result in an increase in A-aDO2.

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What Do You Know About Respiratory Failure? Trivia Questions

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