Prostate Cancer Quiz
28 Questions
| Attempts: 271
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Questions and Answers
- 1.
Common risk factors for prostate cancer include BPH and smoking.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
BPH does not increase the risk, although it may delay diagnosis. Smoking does not increase the risk but it does increase mortality once diagnosed.Rate this question:
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- 2.
Elevated PSA levels show a patient has an increased chance of having prostate cancer. Some drugs decrease these levels by 50% after 6 to 12 months of use. These drugs include:
- A.
Finasteride
- B.
Dutasteride
- C.
Androgen receptor blockers
- D.
Saw Palmetto
- E.
St John's Wort
Correct Answer(s)
A. Finasteride
B. Dutasteride
C. Androgen receptor blockers
D. Saw PalmettoExplanation
Androgen receptor blocker examples are bicalutamide and flutamide.Rate this question:
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- 3.
According to ACS screening guidelines, African Americans are at higher risk for prostate cancer and should be screened sooner.
- A.
True
- B.
False
Correct Answer
A. True -
- 4.
The American Cancer Society, NCCN, and US Preventative Services Task Force all have similar screening guidelines.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
There is actually a lot of controversy between the guidelines.Rate this question:
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- 5.
Which Gleason grade group has the best prognosis?
- A.
Gleason grade group 1
- B.
Gleason grade group 5
- C.
Gleason grade group 2
- D.
Gleason grade group 3
- E.
Gleason grade group 4
Correct Answer
A. Gleason grade group 1 -
- 6.
What levels of risk of recurrence have observation as a treatment option?
- A.
Very Low
- B.
Low
- C.
Intermediate
- D.
High
- E.
Very High
Correct Answer(s)
A. Very Low
B. Low
C. IntermediateExplanation
Very low: observation only if life expectancy is less than 20 yrs. Observation, prostatectomy, or radiation if life expectancy is 20+ yrs.
Low: observation only if life expectancy is < 10 yrs. Observation, prostatectomy, or radiation if life expectancy is 10+ yrs.
Intermediate: Observation, prostatectomy, or radiation +/- ADT (4-6 months) if life expectancy isRate this question:
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- 7.
Active surveillance is use for life expectancy > 10 years and observation is used for life expectancy < 10 years
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
For active surveillance, progression will start curative treatment. For observation, progression will start palliative treatment. Patient must understand that tumor will progress during active surveillance or observation.Rate this question:
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- 8.
What are some advantages to active surveillance or observation?
- A.
Avoid side effects of treatment
- B.
Quality of life maintained
- C.
Decreased costs
- D.
Avoid unnecessary treatment of small, indolent cancers
- E.
2/3 of men eligible for active surveillance will avoid treatment
- F.
Decreased anxiety
- G.
No biopsies
Correct Answer(s)
A. Avoid side effects of treatment
B. Quality of life maintained
C. Decreased costs
D. Avoid unnecessary treatment of small, indolent cancers
E. 2/3 of men eligible for active surveillance will avoid treatmentExplanation
Biopsies are actually disadvantages. Patient will undergo periodic biopsies and multiple biopsies can make prostatectomy challenging. Other disadvantages: increased anxiety, 1/3 men will require treatment, and missed opportunity for cure.Rate this question:
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- 9.
Prostatectomy is an option for almost any risk for recurrence except for very low risk.
- A.
True
- B.
False
Correct Answer
A. True -
- 10.
Radiation is an option for every risk for recurrence.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
Radiation is an option for every risk except for very low.Rate this question:
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- 11.
External Beam Radiation Therapy (EBRT) is the only radiation therapy used for prostate cancer.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
There are actually many types of radiation for prostate cancer. She said we didn't have to memorize them all, just know that there are many types.Rate this question:
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- 12.
Adnroge Deprivation Therapy (ADT) is indicated for use in which risk of recurrence levels? (select all that apply)
- A.
Intermediate
- B.
High
- C.
Very High
- D.
Low
- E.
Very Low
Correct Answer(s)
A. Intermediate
B. High
C. Very HighExplanation
Used with radiation therapy for 2-3 years in high risk of very high risk patients and for 4-6 months in intermediate risk patients.Rate this question:
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- 13.
Antiandrogens can help control tumor flair caused by LH-RH agonists.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
Tumor flair is caused by the initial increase in gonaotropins due to the LH-RH agonist. With the increase in gonadotropins, there is a negative feedback effect and with chronic administration we see sustained suppression of pituitary gonadotropins. The initial increase in gonadotropins leads to increased androgens such as testosterone which is what causes the tumor flair. With antiandrogens on board, the androgen increase has no affect on the tumor.Rate this question:
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- 14.
LHRH antagonists have no effect on tumor flare and castrate levels are achieved within 7 days.
- A.
True
- B.
False
Correct Answer
A. True -
- 15.
Which drugs are LH-RH agonists?
- A.
Goserelin
- B.
Leuprolide
- C.
Triptorelin
- D.
Degarelix
- E.
Abaralix
Correct Answer(s)
A. Goserelin
B. Leuprolide
C. TriptorelinExplanation
Degarelix and abaralix are LHRH antagonists.Rate this question:
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- 16.
How often should PSA be checked to monitor for recurrent prostate cancer?
- A.
Every 6-12 months for 5 years then yearly thereafter
- B.
Every month for 5 years
- C.
Every 6 months for the rest of the patient's life
- D.
PSA is not used to monitor for recurrent prostate cancer
Correct Answer
A. Every 6-12 months for 5 years then yearly thereafterExplanation
A rising PSA is an indicator for recurrent cancer.Rate this question:
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- 17.
A patient presents with metastatic prostate cancer, impending spinal cord compression and ureteral obstruction. What is the preferred initial treatment.
- A.
Bilateral orchiectomy
- B.
Docetaxel
- C.
LH-RH agonist
- D.
LH-RH antagonist
Correct Answer
A. Bilateral orchiectomyExplanation
A bilateral orchiectomy is removal of the testes to create an immediate drop in testosterone within 12 hours. The other options listed above are options to treat metastatic disease but in this emergency situation, the patient's best option was surgery.Rate this question:
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- 18.
Select the drugs that are antiandrogens from the list below: (select all that apply)
- A.
Bicalutamide
- B.
Flutamine
- C.
Nilutamide
- D.
Degarelix
- E.
Leuprolide
Correct Answer(s)
A. Bicalutamide
B. Flutamine
C. Nilutamide -
- 19.
A slight survival benefit has been seen with intermittent use of androgen deprivation therapy in castrate sensitive metastatic disease.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
Continuous ADT shows the slight survival benefit. If there are no symptoms from the ADT then it should be continued. If there are symptoms but the patient is low or intermediate risk, then intermediate use should be considered for QoL.Rate this question:
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- 20.
Combined androgen blockade (CAB) is when an LHRH agonist and and antiandrogen are used together.
- A.
True
- B.
False
Correct Answer
A. True -
- 21.
Drugs (combos) used to treat castrate-recurrent (resistant) metastatic disease include
- A.
Abiraterone/Prednisone
- B.
Docetaxel/Prednisone
- C.
Enzalutamide
- D.
Sipuleucel-T
- E.
Bicalutamide
Correct Answer(s)
A. Abiraterone/Prednisone
B. Docetaxel/Prednisone
C. Enzalutamide
D. Sipuleucel-T -
- 22.
Hallmark toxicities of Abiraterone include:
- A.
Fatigue
- B.
Edema
- C.
Heart Failure
- D.
Diarrhea
- E.
Peripheral edema
Correct Answer(s)
A. Fatigue
B. Edema -
- 23.
Hallmark toxicities of docetaxel include:
- A.
Complete alopecia
- B.
Edema
- C.
Diarrhea
- D.
Hot flashes
- E.
Fatigue
Correct Answer(s)
A. Complete alopecia
B. Edema -
- 24.
Out of the options for metastatic castrate-recurrent prostate cancer, Enzalutamide has the lowest potential for drug-drug interactions.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
Enzalutamide is a strong CYP3A4 inducer and a moderate CYP2C9 and CYP2C19 inducer. Avoid co-administration with CYP2C8 inhibitors. If you can't avoid, then decrease the dose to 80mg.Rate this question:
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- 25.
Sipuleucel-T is the first vaccine approved for treatment in metastatic castrate-recurrent prostate cancer.
- A.
True
- B.
False
Correct Answer
A. True -
- 26.
Docetaxel is used in patients with metastatic castrate-recurrent prostate cancer who previously treated with cabazitaxel.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
False, it is the other way around. Cabazitaxel is used for metastatic prostate cancer previously treated with a docetaxel-containing regimen.Rate this question:
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- 27.
Select the drugs of choice for bone metastases.
- A.
Zoledronic Acid
- B.
Denosumab
- C.
Docetaxel
- D.
Tamsuosin
Correct Answer(s)
A. Zoledronic Acid
B. DenosumabExplanation
The two drugs are both bisphosphonates, a drug class used for bone metastases.Rate this question:
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Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.
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Current Version
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May 02, 2017Quiz Edited by
ProProfs Editorial Team -
May 01, 2017Quiz Created by
Ashleynecole
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