Viral Hepatitis Prt 2

18 Questions | Total Attempts: 232

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Viral Hepatitis Prt 2

Having covered all there is to viral hepatitis it is now time to see how much you understood. Take up this part two quiz and see if you can identify the causes, effect and how one comes to diagnosing a patient. All the best and ensure you go back to your nooks on what you get wrong.


Questions and Answers
  • 1. 
    A 38-year-old woman screened for hepatitis presents the following serological status: HBsAg                   negative HBcAg IgG           positive HBsAg IgG            negative What is the most likely explanation for these results?
    • A. 

      Vaccination

    • B. 

      Resolved acute infection

    • C. 

      Chronic infection with undetectable HBsAg

    • D. 

      This is impossible

  • 2. 
    A 27-year-old female sex worker presents to a free clinic complaining of tea-colored urine and clay-colored stools. Patient history reveals a recent trip to Mexico and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. She admits to alcohol and injection drug abuse. Physical examination reveals epigastric discomfort and yellow-tinged sclerae. Blood work shows the following: Three years later, a new panel is performed on the same patient, with the following results: What is the status of this patient?  
    • A. 

      Acute HBV

    • B. 

      Chronic HBV

    • C. 

      Chronic, minimally replicating HBV

    • D. 

      Chronic, HBeAg-negative mutant HBV

  • 3. 
    How likely is it for this person to transmit the infection?
    • A. 

      Unlikely

    • B. 

      Likely

    • C. 

      Highly likely

  • 4. 
    A 27-year-old female sex worker presents to a free clinic complaining of tea-colored urine and clay-colored stools. Patient history reveals a recent trip to Mexico and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. She admits to alcohol and injection drug abuse. Physical examination reveals epigastric discomfort and yellow-tinged sclerae. Blood work shows the following: Three years later, a new panel is performed on the same patient, with the following results:   What is the status of this patient?
    • A. 

      Acute HBV

    • B. 

      Chronic HBV

    • C. 

      Chronic, minimally replicating HBV

    • D. 

      Chronic, HBeAg-negative mutant HBV

  • 5. 
    A 27-year-old female sex worker presents to a free clinic complaining of tea-colored urine and clay-colored stools. Patient history reveals a recent trip to Mexico and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. She admits to alcohol and injection drug abuse. Physical examination reveals epigastric discomfort and yellow-tinged sclerae. Blood work shows the following: Three years later, a new panel is performed on the same patient, with the following results: What is the status of this patient?
    • A. 

      Acute HBV

    • B. 

      Chronic HBV

    • C. 

      HBV-HDV co-infection

    • D. 

      HBV-HDV super-infection

  • 6. 
    A 25-year-old pregnant woman (2nd trimester) presents with tea-colored urine and clay-colored stools. Patient history reveals a recent trip to India and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. Physical examination reveals yellow-tinged sclerae. Blood work shows the following: One month later, a new panel is performed on the same patient, with the following results: What is the most likely cause of this patient’s hepatitis?
    • A. 

      HAV

    • B. 

      HBV

    • C. 

      HCV

    • D. 

      HDV

    • E. 

      HEV

  • 7. 
    What is the case fatality rate in this population of patient?
    • A. 

      0-10%

    • B. 

      10-20%

    • C. 

      20-30%

    • D. 

      30-40%

    • E. 

      40-50%

  • 8. 
    A 31-year-old male sex worker presents to a free clinic complaining of tea-colored urine and clay-colored stools. Patient history reveals a recent trip to Mexico and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. He admits to alcohol and injection drug abuse. Physical examination reveals epigastric discomfort and yellow-tinged sclerae. Blood work shows the following: What is the status of this patient?
    • A. 

      Acute HBV

    • B. 

      Chronic HBV

    • C. 

      Acute HCV

    • D. 

      Chronic HCV

    • E. 

      Acute HBV/Chronic HCV

    • F. 

      Chronic HBV/Acute HCV

  • 9. 
    What would be the most likely serology profile of a person vaccinated for both HAV and HBV?
    • A. 

      I

    • B. 

      II

    • C. 

      III

    • D. 

      IV

    • E. 

      V

    • F. 

      VI

    • G. 

      VII

    • H. 

      VIII

  • 10. 
    A 27-year-old female sex worker presents to a free clinic complaining of tea-colored urine and clay-colored stools. Patient history reveals a recent trip to Mexico and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. She admits to alcohol and injection drug abuse. Physical examination reveals epigastric discomfort and yellow-tinged sclerae. Blood work shows the following: Three years later, a new panel is performed on the same patient, with the following results: What is the status of this patient (choose the best answer)?  
    • A. 

      Resolved HBV infection

    • B. 

      Resolved HDV infection

    • C. 

      Resolved HBV-HDV co-infection

    • D. 

      Resolved HBV-HDV super-infection

  • 11. 
    What important consideration must be made when treating an HIV-HBV co-infected individual with antivirals?
    • A. 

      Need to wait until CD4 count drops to less than 200/mL

    • B. 

      Care must be taken to choose a nucleoside analog that has a low probability of inducing resistance in HBV

    • C. 

      IFN-a should be avoided

    • D. 

      Care must be taken to choose a nucleoside analog that has a low probability of inducing resistance in HIV

  • 12. 
    What conclusion(s) should be drawn from the following lab results? Three years later, a new panel is performed on the same patient, with the following results:
    • A. 

      Resolved HBV infection

    • B. 

      Current HDV infection

    • C. 

      Resolved HBV-HDV co-infection

    • D. 

      Resolved HBV-HDV super-infection

  • 13. 
    A patient with the following lab results undergoes treatment with peg-IFN-and ribavirin: What is the most likely presentation of this patient?
    • A. 

      Icteric

    • B. 

      Asymptomatic

  • 14. 
    What mechanism(s) contributed to the establishment of chronic disease?
    • A. 

      Disruption of Jak/STAT-mediated IFN signaling

    • B. 

      Induction of Treg-mediated immune tolerance

    • C. 

      Disruption of RIG-1- and TLR3-mediated viral recognition

    • D. 

      Capacity of the virus to cause little cytopathic effects

    • E. 

      All of the Above

  • 15. 
    Which molecule expression is likely to be increased as a result of peg-IFN-a treatment?
    • A. 

      PRB

    • B. 

      IFN-y

    • C. 

      Lactoferrin

    • D. 

      Cathepsin H

    • E. 

      Pkr

  • 16. 
    Which HCV genotype and viral replication status is hardest to treat?
    • A. 

      Genotype 1/RNA low

    • B. 

      Genotype 1/RNA high

    • C. 

      Genotype 2

    • D. 

      Genotype 3

  • 17. 
    Which mechanisms are involved in the development of HCC?
    • A. 

      Chronic inflammation

    • B. 

      Oxygen radical production by immune cells

    • C. 

      P53-mediated apoptosis

    • D. 

      Oncogene activation by viral transactivator

    • E. 

      ADCC

    • F. 

      All of the Above

  • 18. 
    Which HBV components are involved in the induction of tolerance and the establishment of chronic disease? Check ALL that apply
    • A. 

      HBs

    • B. 

      HBc

    • C. 

      HBe

    • D. 

      HBx

    • E. 

      RT