Quis Teknologi Sediaan Steril- S1 Farmasi- VI

The correct answer is 120oC selama 15 menit. Autoclaves are commonly used in pharmaceutical industries for sterilizing medical equipment and substances. The recommended temperature and time for sterilization using an autoclave are 120oC for 15 minutes. This combination of temperature and time ensures the effective killing of microorganisms, including bacteria, viruses, and spores, present in the infusion solution.

Metilen biru 0.1% digunakan sebagai larutan warna dalam pemeriksaan kebocoran pada hasil produksi setelah pembuatan sedian steril. Larutan ini digunakan untuk melihat adanya kebocoran pada sedian steril dengan cara memasukkan larutan ke dalam sedian tersebut. Jika terdapat kebocoran, larutan akan keluar dan terlihat melalui warna biru metilen biru 0.1%. Metilen biru 0.1% dipilih karena konsentrasi yang rendah membantu memastikan bahwa kebocoran yang kecil atau mikroskopis pun dapat terdeteksi dengan jelas.

The correct answer is "Uji pirogen". Pirogen adalah zat yang dapat menyebabkan demam atau reaksi inflamasi pada tubuh manusia. Uji pirogen dilakukan untuk memastikan bahwa sediaan injeksi bebas dari pirogen, sehingga tidak menyebabkan reaksi demam pada pasien. Dalam konteks ini, apoteker ingin membatasi resiko reaksi demam pada tingkat yang dapat diterima oleh pasien pada pemberian sediaan injeksi, sehingga uji pirogen menjadi relevan.

The correct answer is "Kelas A". In the pharmaceutical industry, the production of sterile products is divided into different cleanliness classes. Class A is the highest level of cleanliness and is required when performing high-risk activities such as filling zones, opening rubber stoppers, ampoules, and vials. This class ensures the highest level of sterility and minimizes the risk of contamination.

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The correct answer is No 3 because it shows the route of administration through Intravenous (IV) injection.

The correct answer is "Ampul." Ampul is a type of single-dose container used for injections. It is a small glass or plastic vial that is sealed to maintain sterility and contains a single dose of medication. Ampuls are commonly used for medications that need to be protected from air and light.

The correct answer is "Uji sterilitas". The explanation is that the pharmacist is preparing a sterile injection solution of dexamethasone. As part of the evaluation process, one of the evaluations conducted is the sterility test. This test is important to ensure that the injection solution is free from any microorganisms that could cause contamination or harm to the patient.

The correct answer is to inoculate the sample onto agar medium and observe microbial growth after incubation. This method is commonly used to test the sterility of a solution. By inoculating the sample onto agar, any potential microbial contaminants present in the solution will have the opportunity to grow and form visible colonies. After incubation, the presence or absence of microbial growth can be observed, indicating whether the solution is sterile or not.

The correct answer is "Sel akan mengkerut" (Cells will shrink). When a hypertonic solution is injected into the body, the concentration of solutes outside the cells is higher than inside the cells. As a result, water from the cells will move out to balance the concentration, causing the cells to shrink or shrivel up. This is known as plasmolysis, and it can have various physiological effects on the tissues of the rabbit's body.

The correct answer is "Intraartikular." Intraartikular means that the medication is administered directly into the joint. In this case, the patient has inflammation in the knee joint, so the doctor administers the medication directly into the knee joint to target the affected area.

The correct answer is "Sering berkaitan dengan sifat pirogen yang thermostabil dan non-volatile." Pirogens are often associated with their thermostable and non-volatile properties, meaning they can withstand high temperatures and do not easily evaporate. This is important in the context of infusions, as the presence of pirogens can cause fever and other adverse reactions in patients. Therefore, it is necessary for the carrier material, active substance, and infusion equipment to be free from pirogens.

The correct answer is "Sterilisasi panas basah". Sterilisasi panas basah adalah proses sterilisasi yang menggunakan panas dan uap air untuk membunuh mikroorganisme dan sporanya. Proses ini dilakukan dalam bejana bertekanan yang didesain seperti autoklaf dengan modifikasi tertentu.

The correct answer is "Pemeriksaan kejernihan larutan, penentuan pH, pemeriksaan kebocoran." This is because when evaluating the sterility of a microorganism in an injectable product like Chlorbutanol, it is important to check the clarity of the solution, as well as the pH level to ensure it is within the acceptable range. Additionally, checking for leakage is crucial to ensure the integrity of the product and prevent contamination.

The evaluation mentioned in the passage is done to improve the stability of the injection formulation. This evaluation includes the evaluation of drug substances, excipients, and solvents, with a focus on buffer pH up to 7.4. By evaluating these components, the formulation can be optimized to ensure that it remains stable over time, preventing any degradation or loss of efficacy.

The correct answer is "Sediaan steril dengan volume

The correct answer is Sterilisasi Panas Kering because dry heat sterilization is suitable for the preparation of ointments. This method uses high temperatures to kill microorganisms and is effective in ensuring the sterility of the eye ointment. Wet heat sterilization, filtration, ionizing radiation, and UV sterilization may not be suitable for this particular formulation.

Injections are administered directly into the bloodstream, bypassing the external environment. Therefore, they do not come into direct contact with air, reducing the risk of oxidation. As a result, there is no need to add antioxidants to injections to prevent oxidation.

The question asks for the value of the hypotonicity of the solution. The correct answer is "0.23

The correct answer is "Guttae auricularis" because it refers to ear drops, not eye drops. The question asks for the sediaan steril mata (sterile eye preparations), so Guttae auricularis does not belong in this category.

The given statement mentions that the glass container is sterilized using dry heat before being filled with the product aseptically. It also states that autoclaving is not done because it may damage the inner part of the container and release alkali. Based on this information, the glass container can be classified as Type III. Type III glass containers have good chemical resistance and are suitable for dry heat sterilization methods.

The given correct answer is "Daerah Merah". The explanation for this answer is that in the process of making sterile preparations, the pharmacist enters a clean room or controlled environment to minimize the risk of microbial contamination. The clean room is often divided into different zones based on the level of cleanliness required. The zones typically include the Aseptic Zone (Daerah Aseptis), where the highest level of cleanliness is maintained, the White Zone (Daerah Putih), the Gray Zone (Daerah Abu-Abu), and the Black Zone (Daerah Hitam). The Red Zone (Daerah Merah) is not a recognized zone in the production of sterile preparations.

The correct answer is 0.283 gr/100 ml because it is the result of the calculation to achieve isotonicity in the infusion solution. Isotonicity refers to the balance of solute concentration inside and outside the cells, and it is important in order to prevent adverse effects on the body. The calculation takes into account the molecular weight and dissociation degree of the substances used in the infusion solution.

The formula provided consists of Acidium Citricum, Na Citrat Tribacicum, Glukosa p.i anhydrous, and Aqua p.i ad. The concentration of Glukosa p.i anhydrous is 25 g/L. The term "Hipotonis" refers to a solution with a lower osmotic pressure compared to another solution. Adding Glukosa p.i anhydrous at a concentration of 4.36 g/L would decrease the osmotic pressure of the solution, making it hypotonic. Therefore, the correct answer is "Hipotonis, penambahan glukosa 4,36 g/L."

Placing items in the location where the laminar air flows out is incorrect because it can disrupt the airflow and compromise the sterility of the environment. In a Bio Safety Cabinet (BSC), items should be placed inside the cabinet in designated areas to maintain a clean and organized workspace.

When a hypotonic solution is injected into the body tissue, the solution has a lower solute concentration compared to the inside of the cells. As a result, water molecules will move into the cells through osmosis, causing the cells to swell and potentially burst. This is known as cell lysis or cell rupture. Therefore, the correct answer is "Sel akan pecah" which means "Cells will burst."

The correct answer is "Pendapar." The explanation for this answer is that the process of making a naphazoline HCL 0.012% eye solution by filtration is a form of buffering. Buffering is the process of maintaining a stable pH level in a solution, which is important for ensuring the stability of the medication when applied to the eye. By filtering the solution, the student is likely removing any impurities or particles that could potentially affect the pH of the solution.

The correct answer is 0.059 gram because to make a solution isotonic, the total concentration of solutes should be equal to the concentration of solutes in the body's fluids. In this case, the concentration of Ampisilin Na is 0.05 gram and the concentration of Efedrin sulfat is 0.1 gram. To calculate the concentration of NaCl needed to make the solution isotonic, we can use the formula: (0.05 + 0.1) / 10 = 0.015 gram per ml. Since the solution is 10 ml, we multiply the concentration by 10, resulting in 0.015 * 10 = 0.15 gram. However, the question asks for the amount of NaCl in grams, so we need to convert the concentration to grams by multiplying by 10, resulting in 0.15 * 10 = 0.059 gram.

To calculate the amount of NaCl needed to make the preparation isotonic, we need to use the formula for calculating the osmolarity of a solution. Osmolarity is the concentration of solutes in a solution and is measured in osmoles per liter (osmol/L).

First, we need to calculate the osmolarity of the Theophyllin solution. The molecular weight of Theophyllin (MA) is given as 198.18 g/mol. Since Theophyllin is a weak base, we need to convert it to its salt form by adding Etilendiamin. The molecular weight of Etilendiamin (MB) is given as 78.1 g/mol.

The osmolarity of Theophyllin solution can be calculated using the formula:
Osmolarity = (MA * concentration of Theophyllin) + (MB * concentration of Etilendiamin)

Substituting the given values:
Osmolarity = (198.18 * 1) + (78.1 * 0.55) = 198.18 + 42.955 = 241.135 osmol/L

Next, we need to calculate the osmolarity of the final preparation. The osmolarity of the final preparation should be equal to the osmolarity of the human body, which is around 300 mOsmol/L.

The osmolarity of the final preparation can be calculated using the formula:
Osmolarity = (MA * concentration of Theophyllin) + (MB * concentration of Etilendiamin) + (Mh * concentration of NaCl)

Substituting the given values and assuming the concentration of NaCl as Fh NaCl:
300 = (198.18 * 1) + (78.1 * 0.55) + (58.5 * Fh NaCl)

Solving for Fh NaCl, we get:
Fh NaCl = (300 - 198.18 - 42.955) / 58.5 = 58.865 / 58.5 = 1.006

Therefore, the amount of NaCl needed to make the preparation isotonic is 1.006 g. Rounding to three decimal places, the correct answer is 0.126 g.

The correct answer is the fourth option: Melepas sepatu dan baju rumah, ganti dengan baju kelas A/B, melepas baju A/B untuk ganti baju kelas C, menuju ruang produksi. This is because the person should start by removing their shoes and home clothes, then change into class E/D clothes. After that, they should remove the E/D clothes and change into class A/B clothes. Finally, they can proceed to the production room.