Pathophysiology Chapter 50

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1. In myasthenia gravis, periods of stress can produce myasthenia crisis. When does myasthenia crisis occur?

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Pathophysiology Quizzes & Trivia

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2. The pathophysiology of multiple sclerosis involves the ________ of nerve fibers in the white matter of the brain, spinal cord, and optic nerve.

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3. The cardinal manifestations of Parkinson disease are tremor, rigidity, and ________ or slowness of movement. 

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4. A group of deep, interrelated subcortical nuclei that play an essential role in control of movement

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5. Motor neuron and the group of muscle fibers it innervates in a muscle

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6. Nystagmus

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7. Serves as a synapse between a motor neuron and a skeletal muscle fiber

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8. Neurotoxins from the botulism organism (Clostridium botulinum) produce paralysis by blocking _________

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9. What usually results from lower motor neuron (LMN) lesions as well as diseases of the muscles themselves?

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10. A 14-year-old girl has been thrown from the back of a pick-up truck. MRI shows broken vertebrae at the C2 level. What is the main significance of an injury at this level of the spinal column?

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11. Sense of body movement and position

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12. Slowness of movement

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13. Antibiotics, such as gentamicin, can produce a disturbance in the body that is similar to botulism by preventing the release of acetylcholine from nerve endings. In persons with preexisting neuromuscular transmission disturbances, these drugs can be dangerous. What disease falls into this category?

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14. Peripheral nerve disorders are not uncommon. what is an example of fairly common mononeuropathy?

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15. The failure to accurately perform rapid alternating movements

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16. Inherited as a recessive single-gene defect on the X chromosome and it is transmitted from the mother to her male offspring.

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17. Maintains equilibrium and posture

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18. The most common cause of _________ is motor vehicle accidents, followed by falls, violence (primarily gunshot wounds), and recreational sporting activities.

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19. Reflexes are basically "hard-wired" into the central nervous system. Automatically, the basis of a reflex is an afferent neuron that synapses directly with an effector neuron that causes muscle movement. Sometimes the afferent neuron synapses with what intermediary between the afferent and effector neurons?

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20. The high risk for ________ in patients with acute SCI is owing to immobility, decreased vasomotor tone below the level of injury, and hypercoagulability and stasis of blood flow.

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21. Vagal stimulation that causes a marked bradycardia is called what?

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22. Loss of movement

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23. Somatotopic array of the body representing motor areas

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24. Involuntary motor responses

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25. Suggests the presence of a LMN lesion

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26. A term applied to a number of genetic disorders that produce progressive deterioration of skeletal muscles because of mixed muscle cell hypertrophy, atrophy, and necrosis.

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27. Muscle shrinkage owing to loss of neural stimulus

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28. What disease results from the degeneration of the dopamine nigrostriatal system of the basal ganglia?

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29. Incomplete loss of strength 

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30. A wide-based, unsteady gait

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31. Unsteadiness of the trunk

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32. Duchenne muscular dystrophy usually does not produce any signs or symptoms until between the ages of 2 and 3. What muscles are usually first to be affected in Duchenne muscular dystrophy?

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33. What is involved in one or more interposed interneurons?

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34. Syndrome arising from the degenerative changes in basal ganglia function

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35. What are distributed throughout the belly of a muscle to relay information about muscle length and rate of stretch?

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36. If the LMN dies or its axon is destroyed, the skeletal muscle cell begins to have temporary spontaneous contractions called what?

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37. Inaccuracies of movements, leading to a failure to reach a specified target

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38. Affects motor neurons in three locations: the anterior horn cells of the spinal cord; the motor nuclei of the brain stem, particularly the hypoglossal nuclei; and the UMNs of the cerebral cortex

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39. The ________ contains the neuronal circuits that mediate a variety of reflexes and automatic rhythmic movements.

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40. Any interruption of the myotatic or stretch reflex circuitry by peripheral nerve injury, pathology of the neuromuscular junction, injury to the spinal cord, or damage to the corticospinal system can result in disturbances of ________.

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41. Hyperactive reflexes are suggestive of what?

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42. Involve demyelination or axonal degeneration of multiple peripheral nerves that leads to symmetric sensory, motor, or mixed sensorimotor deficits

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43. The spinal cord contains the basic factors necessary to coordinate function when a movement is planned. It is the lowest level of function. What is the highest level of functioning in planning movement?

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44. ________, whether it involves walking, running, or precise finger movements, requires movement and maintenance of posture.

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45. Bowel dysfunction is one of the most difficult problems to handle after a spinal cord injury. After a spinal cord injury, most people experience constipation. Why does this occur?

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46. Sudden complete ____________ results in complete loss of motor, sensory, relfex, and autonomic function below the level of injury.

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47. A disorder of transmission at the neuromuscular junction that affects communication between the motor neuron and the innervated muscle cell

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48. Although no laboratory test is diagnostic for multiple sclerosis (MS), some patients have alterations in their cerebrospinal fluid (CSF) that can be seen when a portion of the CSF is removed during a spinal tap. What finding in CSF is suggestive of MS?

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49. Disorders of the basal ganglia comprise a complex group of motor disturbances characterized by ________ and other involuntary movements, changes in posture and muscle tone, and poverty and slowness of movement.

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50. Provides the circuitry for coordinating the movements of the distal portions of the limbs.

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51. Abnormalities in any part of the __________ can produce muscle weakness.

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52. Rhythmic contraction and alternate relaxation of a limb

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53. Visible squirming and twitching movements of muscle

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54. Increased muscle resistance that varies and commonly becomes worse at the extremities of the range of motion

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55. Herniated disks occur when the nucleus pulposus is compressed enough that it protrudes through the annulus fibrosus putting pressure on the nerve root. This type of injury occurs most often in the cervical and lumbar region of the spine. What is an important diagnostic test for a herniated disk in the lumbar region?

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56. The basal ganglia play a role in coordinated movements. Part of the basal ganglia system is the striatum which involves local cholinergic interneurons. What disease is thought to be related to the destruction of the cholinergic interneurons?

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57. Progressive neurological illnesses that selectively affect the anterior horn cells of the spinal cord and cranial nerve motor neurons

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58. There are two main types of ______ based on the target of the insult: segmental demyelination involving the Schwann cell and axonal degeneration involving the neuronal cell body and/or its axon.

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59. Control motor function

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60. The motor neurons supplying a motor unit are located in the ventral horn of the spinal cord

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61. Refers to impairment or loss of motor or sensory function (or both) in the thoracic, lumbar, or sacral segments of the spinal cord from damage of neural elements in the spinal canal. 

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62. What is found in muscle tendons and transmits information about muscle tension or force of contraction at the junction of the muscle and the tendon that attaches to bone?

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63. Stretch reflexes tend to be hypoactive or absent in cases of ____________ damage or ventral horn injury involving the test area.

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64. Rhythmic movements of a particular body part

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65. At what level of the cervical spine would an injury allow finger flexion?

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66. Characterized by inflammation and selective destruction of central nervous system myelin

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67. Are usually caused by localized conditions such as trauma, compression, or infections, that affect a single spinal nerve, plexus, or peripheral nerve trunk

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68. The primary ________ is located on the rostral surface and adjacent portions of the central sulcus

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69. What is controlled by the medial descending systems of the brain stem by integrating visual, vestibular, and somatosensory information?

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70. The _________ provides feedback circuits that regulate cortical and brain stem motor areas.

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71. Abnormal writihing movements

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72. Can result in total incoordination of these functions even though its loss does not result in paralysis

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73. Coordinates sequential body and limb movements

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74. Usually occurs in persons with injuries at T4 and T6 and above and is related to the interruption of descending control of sympathetic outflow to blood vessels in the extremities and abdomen

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75. What is the highest level of motor function?

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76. Cerebellar ________ are involved with the timing and coordination of movements that are in progress and with the learning of motor skills.

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77. The impairment or loss of motor or sensory function (or both) after damage to neural structures in the cervical segments of the spinal cord.

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78. Project from the motor strip in the cerebral cortex to the ventral horn and are fully contained within the central nervous system

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79. Amyotrophic lateral sclerosis (ALS) is considered a disease of the upper motor neurons. What is the most common clinical presentation of ALS?

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80. Disorder affecting the nerve cell body are often referred to ______, those affecting the nerve axon as peripheral neuropathies and primary disorders affecting the muscle fibers as myopathies.

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81. Involuntary jerking movement

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82. Abnormal simultaneous contractions of agonist and antagonist muscles

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83. The signs and symptoms produced by disorders of the motor system are useful in finding the disorder. What signs and symptoms would you assess when looking for a disorder of the motor system? Mark all that apply

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84. The signs and symptoms of ________ are localized to the area of the body innervated by the nerve roots and include both motor and sensory manifestations

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85. Approximately 6 months after a spinal cord injury, a 29-year-old man has an episode of autonomic dysreflexia. What are the characteristics of autonomic dysreflexia? Mark all that apply.

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In myasthenia gravis, periods of stress can produce myasthenia crisis....
The pathophysiology of multiple sclerosis involves the ________ of...
The cardinal manifestations of Parkinson disease are tremor, rigidity,...
A group of deep, interrelated subcortical nuclei that play an...
Motor neuron and the group of muscle fibers it innervates in a muscle
Nystagmus
Serves as a synapse between a motor neuron and a skeletal muscle fiber
Neurotoxins from the botulism organism (Clostridium botulinum) produce...
What usually results from lower motor neuron (LMN) lesions as well as...
A 14-year-old girl has been thrown from the back of a pick-up truck....
Sense of body movement and position
Slowness of movement
Antibiotics, such as gentamicin, can produce a disturbance in the body...
Peripheral nerve disorders are not uncommon. what is an example of...
The failure to accurately perform rapid alternating movements
Inherited as a recessive single-gene defect on the X chromosome and it...
Maintains equilibrium and posture
The most common cause of _________ is motor vehicle accidents,...
Reflexes are basically "hard-wired" into the central nervous...
The high risk for ________ in patients with acute SCI is owing to...
Vagal stimulation that causes a marked bradycardia is called what?
Loss of movement
Somatotopic array of the body representing motor areas
Involuntary motor responses
Suggests the presence of a LMN lesion
A term applied to a number of genetic disorders that produce...
Muscle shrinkage owing to loss of neural stimulus
What disease results from the degeneration of the dopamine...
Incomplete loss of strength 
A wide-based, unsteady gait
Unsteadiness of the trunk
Duchenne muscular dystrophy usually does not produce any signs or...
What is involved in one or more interposed interneurons?
Syndrome arising from the degenerative changes in basal ganglia...
What are distributed throughout the belly of a muscle to relay...
If the LMN dies or its axon is destroyed, the skeletal muscle cell...
Inaccuracies of movements, leading to a failure to reach a specified...
Affects motor neurons in three locations: the anterior horn cells of...
The ________ contains the neuronal circuits that mediate a variety of...
Any interruption of the myotatic or stretch reflex circuitry by...
Hyperactive reflexes are suggestive of what?
Involve demyelination or axonal degeneration of multiple peripheral...
The spinal cord contains the basic factors necessary to coordinate...
________, whether it involves walking, running, or precise finger...
Bowel dysfunction is one of the most difficult problems to handle...
Sudden complete ____________ results in complete loss of motor,...
A disorder of transmission at the neuromuscular junction that affects...
Although no laboratory test is diagnostic for multiple sclerosis (MS),...
Disorders of the basal ganglia comprise a complex group of motor...
Provides the circuitry for coordinating the movements of the distal...
Abnormalities in any part of the __________ can produce muscle...
Rhythmic contraction and alternate relaxation of a limb
Visible squirming and twitching movements of muscle
Increased muscle resistance that varies and commonly becomes worse at...
Herniated disks occur when the nucleus pulposus is compressed enough...
The basal ganglia play a role in coordinated movements. Part of the...
Progressive neurological illnesses that selectively affect the...
There are two main types of ______ based on the target of the insult:...
Control motor function
The motor neurons supplying a motor unit are located in the ventral...
Refers to impairment or loss of motor or sensory function (or both) in...
What is found in muscle tendons and transmits information about muscle...
Stretch reflexes tend to be hypoactive or absent in cases of...
Rhythmic movements of a particular body part
At what level of the cervical spine would an injury allow finger...
Characterized by inflammation and selective destruction of central...
Are usually caused by localized conditions such as trauma,...
The primary ________ is located on the rostral surface and adjacent...
What is controlled by the medial descending systems of the brain stem...
The _________ provides feedback circuits that regulate cortical and...
Abnormal writihing movements
Can result in total incoordination of these functions even though its...
Coordinates sequential body and limb movements
Usually occurs in persons with injuries at T4 and T6 and above and is...
What is the highest level of motor function?
Cerebellar ________ are involved with the timing and coordination of...
The impairment or loss of motor or sensory function (or both) after...
Project from the motor strip in the cerebral cortex to the ventral...
Amyotrophic lateral sclerosis (ALS) is considered a disease of the...
Disorder affecting the nerve cell body are often referred to ______,...
Involuntary jerking movement
Abnormal simultaneous contractions of agonist and antagonist muscles
The signs and symptoms produced by disorders of the motor system are...
The signs and symptoms of ________ are localized to the area of the...
Approximately 6 months after a spinal cord injury, a 29-year-old man...
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