What is the importance of citrate in fatty acid metabolism? - ProProfs Discuss
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What is the importance of citrate in fatty acid metabolism?



A. Activation of fatty acid synthetase
B. To Act as a precursor for addition of one carbon units
C. Activation of acetyl-CoA carboxylase
D. To add the activated carbon dioxide in the formation of malonyl-CoA
E. Activation of carnitine acyl transferase

This question is part of

Block 6 The Buxbaum files
Asked by Steward Athinao, Last updated: Jun 28, 2020

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3 Answers

Karthikeyan Pethusamy

Author of "Passing MBBS series - Biochemistry for undergraduates"

Karthikeyan Pethusamy, Research Associate, AIIMS, Delhi, MBBS MD DNB, Delhi

Answered Sep 08, 2019

Citrate helps in the polymerization of acetyl-CoA carboxylase.

 

Sapen Ere

Sapen Ere

Answered Sep 05, 2019

Activation of fatty acid synthase

 

John Smith

John Smith

Answered Sep 09, 2016

Activation of acetyl-coa carboxylase-fa synthesis and b-oxidation must not occur at the same time (futile cycle) compartmentalization: fa synthesis in cytosol, breakdown in mitocondria malonyl-coa (substrate for fa synthesis) shuts down carnitine shuttle (rate-limiting step of fa breakdown) fa synthesis regulated at acetyl-coa carboxylase: citrate signals good nutrition: allosteric insulin=dephosphorylation=activation glucagon + adrenalin=inc camp =phosphorylation=inactivation gene expression: insulin, glucagon# ( slide 57 f.a metab-bux)
 

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