What is the difference between HTS and HCS? - ProProfs Discuss
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What is the difference between HTS and HCS?

Asked by B. Wright, Last updated: Apr 17, 2024

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6 Answers

Denton Perez

Denton Perez

love to pen down the thought on diverse topics.

Denton Perez
Denton Perez, Professor, High School, Utah

Answered Dec 04, 2020

HTS or High Throughput Screening and HCS or High Content Screen are both scientific methods used for the invention of drugs. HTS allows a researcher to carry out millions of chemical, pharmacological, and genetic tests within a short period. This is possible because of the sensitive detectors, devices, and the data processing and control system used in HTS.

This technique makes use of immortalized cells that have been modulated genetically to identify target molecules. This technique can be used to test inhibitors. A researcher that uses this method will find it easy to identify genes, antibiotics, and active compounds that can easily fit in into a bimolecular channel.

On the other hand, HCS possesses similar features to HTS and uses almost the same techniques as HTS. However, HCS gives a more detailed result compared to HTS. This is because, unlike HTS, HCS examine the whole cell and check if there are any changes in the phenotype.

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A. Daniels

A. Daniels

A. Daniels
A. Daniels, Professor, San Diego

Answered Oct 23, 2020

HCS and HTS are related to the field of drug designing. HCS is an abbreviation for High Content Screening. The purpose of this type of screening is to balance between collecting information at a high level. HTS is an abbreviation for High Throughput Screening.

The purpose of this screening is to carry out millions of different types of tests at one time. These tests can be genetic or chemical. This is very efficient in helping with the creation of new drugs. HTS has been around for about thirty years, and with the many experiments it performs, it is essential in advancing medicine.

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B. Denton

B. Denton

Who wants to travel all the world and capture all the moment in his camera.

B. Denton
B. Denton, Traveler, journalism, Greater Manchester

Answered Oct 15, 2020

HTS and HCS are tools utilized in drug designing technology. HTS stands for High Throughput Screening, while HCS stands for High Content Screening, and both are a scientific method of experimentation used in the process of the invention of drugs. It employs sensitive detectors, robotics, liquid handling devices, and data processing and control software. With high throughput screening, a researcher can perform millions of genetic, pharmacological, and chemical experiments in a much shorter time period.

Through this technique, the researcher can detect antibiotics, genes, or active compounds that play a role in the biochemical process. HCS is a technique that shares many of the same criteria as Throughput Screening. The most prominent difference between the two is that HCS obtains multiple readouts from cell analysis. In HCS, live cell imagining is involved.

The purpose is to extract temporal dynamics and spatial information, which means a strong dependence on image analysis. The objective of high content screening is to balance the collection of useful information with high efficiency.

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A. Cook

A. Cook

Find happiness in writing new things.

A. Cook
A. Cook, English Professor, M.A, Ph.D, Kentucky

Answered Oct 08, 2020

HTS and HCS are known to be bi−color screen test rainbows. They are used in order to do drug design. Their differences are not very strict but there are still some differences that will help you understand them better. When you say HTS, this means “High Throughput Screening.”

When you say HCS, this means “High Content Screening.” HTS is considered to be experimentation. This will be used in the process of the invention of drugs. When you say HCS, this means that there are different core techniques that can be used. Remember that both of them are considered to be very dependable. The quality is also great.

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C. Marcus

C. Marcus

C. Marcus
C. Marcus, Content Developer, Washington

Answered Sep 16, 2020

HTS and HCS are common in drug designing technology because they are the main tool used in drug designing technology, meaning they play a vital role in the pharmaceutical industries.

HTS stands for high throughput screening; it is scientific experimentation used in the process of drug invention. HST uses a high detector, robotics, liquid handling devices, data processing, and computer software. HTS helps the researcher to indicate antibiotics, genes, or active compounds which adapt to a particular biomolecular pathway.

HCS stands for high content screening; its aim is to extract temporal dynamics and spital information. It focuses on cell-based target responses HCS assays changes in the phenotype of the whole cell.

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J. Emmerich

J. Emmerich

J. Emmerich
J. Emmerich, Web Content Writer, New York City

Answered May 06, 2020

HCS and HTS are two major tools that are used in drug designing technology. To start with, the full meaning of HTS is High Throughput Screening. It is a scientific method used in carrying out some experiments in the invention of drugs.

It makes use of sensitive detectors, liquid handling devices, control software, robotics, and data processing. With the help of this High Throughput Screening, a researcher can be able to carry out millions of chemical, genetic, and pharmacological tests within a very short time. This technique was discovered about 30 years ago to help to achieve high efficiency with many experiments.

The full meaning of HCS, on the other hand, is High Content Screening. This technique is in various ways, similar to HTS. The main factor that differentiates the two is that High Content Screening obtains several readouts from cell analysis. The aim of HCS is to create a balancing between the collection of comprehensive information and high efficiency.

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