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Which activity will be inhibited when the following patient is given appropriate pharmacotherapy?

Which activity will be inhibited when the following patient is given appropriate pharmacotherapy?

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A previously healthy 32-year-old man is brought to the emergency department because of a 1-day history of intermittent flashing spots and blurred vision, vomiting, confusion, and difficulty walking. He is a painter and says that yesterday he cleaned up a spilled bottle of paint thinner. Ophthalmologic examination shows dilated pupils with hyperemia of the optic disc and retinal edema. Physical examination shows tachypnea. Serum studies show an anion gap metabolic acidosis.

A. Alcohol dehydrogenase
B. Aldehyde dehydrogenase
C. Formaldehyde dehydrogenase
D. Lactate dehydrogenase
E. Pyruvate dehydrogenase

This question is part of NBME 13 section 1 (qst 1-50)
Asked by Wyatt Williams, Last updated: Jun 20, 2018

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6 Answers

marinasharif

Marinasharif

Answered on May 11, 2017

FYI I put formaldehyde dehydrogenase and got it wrong. So the answer must be alcohol deH like @dochenaj said
1
 Reply

tmme

Tmme

Replied on Jun 18, 2017

Hi I also put Formaldehyde dehydrogenase and got it incorrect while doing my online NBME 13.

E. Barnes

But Can you play this?

E. BarnesProfessional Gamer, Professional Gamer, Washington
Professional Gamer, Professional Gamer, Washington

Answered on Feb 26, 2019

The correct answer to this question is A. Alcohol dehydrogenase is a group of dehydrogenase enzymes, a class of zinc enzymes, that catalyze the oxidation of primary and secondary alcohols and facilitate the interconversion of alcohols and aldehydes with the reduction of hydride anion to NAD+ to NADH, the realease of a proton.

Alcohol dehydrogenase will be inhibited because it is the first step in the metabolism of both methanol and ethylene glycol. The patient has tachypea which is abnormally rapid breathing. The patient also has anion gap metabolic acidosis which is the result of type I diabetes, chronic alcoholism, or undernutrition.

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John Adney

John Adney

Answered on Jun 16, 2017

I put A) Alcohol dehydrogenase and I got it right
 Reply

dochenaj

Dochenaj

Answered on Mar 07, 2017

The most appropriate answer would be alcohol dehydrogenase considering it is the first step in the metabolism of both methanol and ethylene glycol.

While formaldehyde dehydrogenase is the second step only in the meta of methanol.
 Reply

amartyagain

Amartyagain

Answered on Dec 02, 2016

Why not fomepizole(alcohol dehydrogenase inhibitor) which is the antidote of methanol poisoning.

 Reply

John Smith

John Smith

Answered on Nov 07, 2016

Formaldehyde dehydrogenase
 Reply