Which of the following regarding PAH is FALSE? - ProProfs Discuss
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Which of the following regarding PAH is FALSE?

Asked by Cardtrick, Last updated: Jan 24, 2024

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cardtrick

cardtrick

cardtrick
Cardtrick

Answered Dec 03, 2018

There is a cure for PAH

(C) is the false statement here. There is actually no cure for PAH. While there are medications to help control the symptoms and provide life-saving therapies, there is still no cure. (A) is true because vasoconstriction is emblematic of hypertension. Recall TPR in the lectures of regular hypertension. (B) is also true.Vascular wall remodeling is especially problematic in the right ventricle. The right ventricle, as mentioned earlier, must work harder and thus must enlarge. This is atypical of the right ventricle and leaking and clots may emerge as a result. (D) is true. And this is important. Vasoconstriction and vasodilation are in a balance. Thromboxane A2 and Endothelin-1 (ET1) promote vasoconstriction. Nitric oxide (NO) and prostaglandin I2 (prostacyclin) promote vasodilation. This is important because drugs have been created to alter this balance and tip the scales for vasodilation. That is, more vasodilation is preferred in this disease state.
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