Which medication instruction should the nurse provide? Dr. Kennedy prescribes glipizide (Glucotrol), an oral antidiabetic agent, for a male client with type 2 diabetes mellitus who has been having trouble controlling the blood glucose level through diet and exercise.

Be sure to take glipizide 30 minutes before meals.”

The client should take glipizide twice a day, 30 minutes before a meal, because food decreases its absorption. The drug doesnt cause hyponatremia and therefore doesnt necessitate monthly serum sodium measurement. The client must continue to monitor the blood glucose level during glipizide therapy.