Osteoporosis Pharmacology (Msq Drill 150)

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  • 1/44 Questions

    Bisphosphonates are antiresorptive agents that work to inhibit:

    • Osteoblasts
    • Osteoclasts
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  • 2. 

    What class of drug is raloxifene (evista) that is also used in the treatment of osteoporosis?

    • Antiresorptive

    • Anabolic

    • Selective estrogen receptor modifier

    Correct Answer
    A. Selective estrogen receptor modifier
  • 3. 

    What about in the liver and bone, what is the mechanism of action of raloxifene (evista?)

    • Estrogen agonist

    • Estrogen antagonist

    Correct Answer
    A. Estrogen agonist
  • 4. 

    A T score between -2.5 and -1 is osteopenia or osteoporosis?

    • Osteopenia

    • Osteoporosis

    Correct Answer
    A. Osteopenia
  • 5. 

    Teriparatide (forte) is an _________ agent that is used to treat osteoporosis.

    • Antiresorptive

    • Anabolic

    • Selective estrogen receptor modifier

    Correct Answer
    A. Anabolic
    Explanation
    It is the only available anabolic agent.

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  • 6. 

    Therefore teriparatide (forteo) stimulates bone growth. True or false?

    • True

    • False

    Correct Answer
    A. True
  • 7. 

    If a patient taking a bisphosphonate starts to have epigastric pain, when should they report it?

    • At the next doctor's appointment

    • At their earliest convenience

    • Immidately - STAT

    Correct Answer
    A. Immidately - STAT
  • 8. 

    Because raloxifene works in the liver, is it necessary to monitor the patient's lipid profile?

    • Yes

    • No

    Correct Answer
    A. Yes
  • 9. 

    For post menopausal women will estrogen replacement therapy be indicated as a way to maintain bone in the prevention of osteoporosis?

    • Yes

    • No

    Correct Answer
    A. Yes
  • 10. 

    Should bisphosphonates be taken with food?

    • Yes, they should always be taken with food with a FULL glass of water

    • No, they should be taken on an empty stomach with a FULL glass of water

    Correct Answer
    A. No, they should be taken on an empty stomach with a FULL glass of water
  • 11. 

    Teriparatide (forteo) is basically used for patients who are at a very high risk of osteoporosis. True of false?

    • True

    • False

    Correct Answer
    A. True
  • 12. 

    If a patient has hypercalciuria, should you administer calcium?

    • Yes

    • No

    Correct Answer
    A. No
  • 13. 

    Is it appropriate to tall a patient that they should not lie down for at least 30 minutes after taking a bisphosphonate and that if they should lie down they should do so after the first food of the day is eaten?

    • Yes, this is appropriate patient education

    • No, this is inappropriate patient education

    Correct Answer
    A. Yes, this is appropriate patient education
  • 14. 

    To maximise absorption of calcium, it shoulde be taken:

    • Once a day

    • Twice a day

    Correct Answer
    A. Twice a day
  • 15. 

    Why do we give calcium and vitamin D to women either at risk for or who have osteoporosis?

    • To encourage bone resorption

    • To maintain bone

    Correct Answer
    A. To maintain bone
  • 16. 

    Should all patients with osteopenia be immediately started on osteoporosis treatment?

    • No, there is no indication

    • Yes, if they have a risk factor

    Correct Answer
    A. Yes, if they have a risk factor
  • 17. 

    Is hypercalciuria and hypercalcemia also a contraindicationfor Vitamin D?

    • Yes

    • No

    Correct Answer
    A. Yes
  • 18. 

    Raloxifene (evista) is indicated for ______________ of osteoporosis.

    • Prevention only

    • Treatment only

    • Prevention and treatment

    Correct Answer
    A. Prevention and treatment
  • 19. 

    A patient with a creatnine clearance of less than _______ should not take bisphosphonates.

    • 15

    • 30

    • 40

    • 45

    Correct Answer
    A. 30
  • 20. 

    What is the daily requirement for elemental calcium?

    • 400-800mg

    • 800-1000mg

    • 1000-1500mg

    Correct Answer
    A. 1000-1500mg
  • 21. 

    Multivitamins usually have about how much Vitamin D?

    • 400-800IU

    • 800-1000OIU

    Correct Answer
    A. 400-800IU
  • 22. 

    Which of the following types of calcium supplements is the cheapest and has the highest amount of elemental calcium by weight?

    • Calcium carbonate

    • Calcium citrate

    • Calcium phosphate

    Correct Answer
    A. Calcium carbonate
  • 23. 

    Osteonecrosis of the jaw is a common side effect of bisphosphonates. True or false?

    • True, it is a common side effect

    • False, it is a rare side effect

    Correct Answer
    A. False, it is a rare side effect
  • 24. 

    Clacitonin reduces the risk of _______ fracture and is thought to also have an ANALGESIC effect.

    • Hip

    • Elbow

    • Distal radius

    • Vertebral

    Correct Answer
    A. Vertebral
  • 25. 

    Vitamin D is usually supplied as Vit D2 and Vit D3. Which one is over the counter?

    • D2

    • D3

    Correct Answer
    A. D3
  • 26. 

    Which of the following calcium supplements needs acid to absorb and should therefore not be taken with proton pump inhibitors. It should be taken with food.

    • Calcium carbonate

    • Calcium citrate

    • Calcium phosphate

    Correct Answer
    A. Calcium carbonate
  • 27. 

    Calcitonin is also used in the treatment of osteoporosis. Is it an antiresorptive or anabolic agent?

    • Antiresorptive

    • Anabolic

    Correct Answer
    A. Antiresorptive
  • 28. 

    In the breast and centrally what is the mechanism of action of raloxifene (evista?)

    • Estrogen agonist

    • Estrogen antagonist

    Correct Answer
    A. Estrogen antagonist
  • 29. 

    Patients less than 50 years old should take ________ of vitamin D per day.

    • 400-800IU

    • 800-1000IU

    • 1000-1500IU

    Correct Answer
    A. 800-1000IU
  • 30. 

    Which of the following should not take teriparatide (forteo?) Patients with:

    • Metabolic bone disease

    • Hypercalcemia

    • Bone malignancy

    • Hyperparathyroidism

    • Children or pregnant women

    Correct Answer(s)
    A. Metabolic bone disease
    A. Hypercalcemia
    A. Bone malignancy
    A. Hyperparathyroidism
    A. Children or pregnant women
  • 31. 

    Which of the following are antiresorptive drugs used to treat osteoporosis?

    • Alendronate (fosamax)

    • Risedronate (actonel)

    • Ibandronate (boniva)

    • Zoledronic acid (reclast)

    • Raloxifene (evista)

    Correct Answer(s)
    A. Alendronate (fosamax)
    A. Risedronate (actonel)
    A. Ibandronate (boniva)
    A. Zoledronic acid (reclast)
  • 32. 

    Patients with which of the following conditions should not take bisphosphonates?

    • Hypocalcemia

    • Renal impairment

    • Esophageal abnormalities

    • Inability to remain upright for at least 30 minutes post dose

    Correct Answer(s)
    A. Hypocalcemia
    A. Renal impairment
    A. Esophageal abnormalities
    A. Inability to remain upright for at least 30 minutes post dose
  • 33. 

    Which of the following types of calcium supplements causes less constipation but is also the most expensive?

    • Calcium carbonate

    • Calcium citrate

    • Calcium phosphate

    Correct Answer
    A. Calcium phosphate
  • 34. 

    Which are the correct pairings?

    • Vit D2 - cholecalciferol

    • Vit D2 - ergocalciferol

    • Vit D3 - ergocalciferol

    • Vit D3 - cholecalciferol

    Correct Answer(s)
    A. Vit D2 - ergocalciferol
    A. Vit D3 - cholecalciferol
  • 35. 

    Can women who are breast feeding take teriparatide (forteo)?

    • Yes

    • No

    Correct Answer
    A. Yes
  • 36. 

    Which of the following are side effects of calcium suplementation?

    • Gas

    • Constipation

    • Diarrhea

    • Nephrolithiasis

    Correct Answer(s)
    A. Gas
    A. Constipation
    A. Nephrolithiasis
  • 37. 

    Which of the following are drugs or classes of drugs that can induce osteporosis?

    • Cheotherapy

    • Steroids such as gluccocorticoid

    • Immunosuppresants used in organ transplantation

    • Excess thyroid replacement

    • Long term heparin

    Correct Answer(s)
    A. Cheotherapy
    A. Steroids such as gluccocorticoid
    A. Immunosuppresants used in organ transplantation
    A. Excess thyroid replacement
    A. Long term heparin
  • 38. 

    Which of the following does not need acid for absorption but has less elemental calcium and is more expensive?

    • Calcium carbonate

    • Calcium citrate

    • Calcium phosphate

    Correct Answer
    A. Calcium phosphate
  • 39. 

    Which of the following also can cause osteoporosis?

    • Proton pump inhibitors such as omeprazole

    • SSRIs

    • Seizure medications

    • Steroids

    • Drugs for hyperthyroidism

    Correct Answer(s)
    A. Proton pump inhibitors such as omeprazole
    A. SSRIs
    A. Seizure medications
    A. Steroids
    Explanation
    drugs for hypothyroidism are associated with osteoporosis if they are given in excess.

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  • 40. 

    1 mcg of Vit D is =  to how many international units?

    • 20

    • 40

    • 60

    • 80

    • 100

    Correct Answer
    A. 40
  • 41. 

    There are some higher potency vitamind D that are used to treat renal osteodystrophy. these include which of the following:

    • 25-hydroxy D3 - calcifediol

    • 25-hydroxy D2 calciferol

    • 1,25 dihydroxyD3 - calitriol

    Correct Answer(s)
    A. 25-hydroxy D3 - calcifediol
    A. 1,25 dihydroxyD3 - calitriol
  • 42. 

    If you take a high dose of vitamin D will it increase or decrease your bone mineral density?

    • Increase

    • Decrease

    Correct Answer
    A. Decrease
  • 43. 

    Calcium can decreased the absorption of which of the following drugs?

    • Levothyroxine

    • Fluoroquinolones

    • Tetracyclines

    • Bisphophonates

    • Propylthiouracil

    Correct Answer(s)
    A. Levothyroxine
    A. Fluoroquinolones
    A. Tetracyclines
    A. Bisphophonates
  • 44. 

    A patient with osteopenia and one risk factor should be started on treatment. Which of the following could be one of the risk factors?

    • Secondary causes such as steroid use

    • History of a fracture

    • Family history of osteoporosis related fractures

    • High 10 year probablity of fracture

    Correct Answer(s)
    A. Secondary causes such as steroid use
    A. History of a fracture
    A. High 10 year probablity of fracture

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  • Feb 16, 2019
    Quiz Edited by
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  • May 08, 2010
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