In the Calvin cycle, one glucose molecule is synthesized using 6 molecules of CO2, 18 molecules of ATP, and 12 molecules of NADPH. The Calvin cycle is a series of chemical reactions that take place in the stroma of chloroplasts, and it is responsible for converting carbon dioxide into glucose, a process known as carbon fixation. CO2 molecules are combined with molecules from ATP and NADPH to form glucose through a series of enzymatic reactions. Therefore, to synthesize one glucose molecule, 6 molecules of CO2, 18 molecules of ATP, and 12 molecules of NADPH are required.