Principles Of Neuroscience

15 Questions  I  By Raskin
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Neuroscience Quizzes & Trivia
Quiz questions to help you prepare for the section on neuropsychiatry.

  
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  • 1. 
    A drug that decreases the activity of dopamine within the dorsolateral prefrontal cortex would be expected to
    • A. 

      Induce both positive and negative symptoms of schizophrenia

    • B. 

      Induce only the positive symptoms of schizophrenia

    • C. 

      Be an effective treatment for schizophrenia

    • D. 

      Decrease the levels of dopamine in the nucleus accumbens

    • E. 

      Be an effective treatment for thought and language disorder


  • 2. 
    PCP acts as a(n) ________ at ___________receptors
    • A. 

      Agonist; NMDA

    • B. 

      Antagonist; dopamine

    • C. 

      Agonist; acetylcholine

    • D. 

      Antagonist; NMDA

    • E. 

      Antagonist; GABA


  • 3. 
    Which of the following would be a negative symptom of schizophrenia?
    • A. 

      Hearing voices that repeat senseless words and phrases

    • B. 

      Experiencing a feeling of euphoria at the start of an episode

    • C. 

      Believing that doctors are part of the plot to poison you

    • D. 

      Thinking you are the most powerful being on earth

    • E. 

      Exhibiting flattened emotional expression


  • 4. 
    In which of the following would you expect to observe an enlarged hippocampal formation
    • A. 

      A London cabby who has 30 years of experience

    • B. 

      A pigeon that wanders from roost to roost

    • C. 

      A bird that only eats from your backyard feeder

    • D. 

      A person who has just started training as a London cabby

    • E. 

      A chickadee tested in the early summer


  • 5. 
    The hippocampus receives inputs from
    • A. 

      The entorhinal cortex

    • B. 

      The amygdala

    • C. 

      Various regions of the limbic cortex

    • D. 

      All association areas of the neocortex

    • E. 

      All of the above


  • 6. 
    Patient RB who sustained brain damage while in cardiac arrest, exhibited profound anterograde amnesia. What region of the brain was injured?
    • A. 

      Field CA1 of the hippocampal formation

    • B. 

      The perirhinal cortex

    • C. 

      The parahippocamal cortex

    • D. 

      The amygdala

    • E. 

      The central nucleus of the amygdala


  • 7. 
    The verbal abilities of HM are intact except
    • A. 

      He cannot talk of events that occurred prior to 1953

    • B. 

      His ability to spell simple words such as "and" and "but"

    • C. 

      He cannot talk about mathematical operations

    • D. 

      He is not proficient in post 1953 American vocabulary

    • E. 

      Both a and c


  • 8. 
    The common aspect of all natural reinforcers relates to
    • A. 

      The release of dopamine within the nucleus accumbens

    • B. 

      The release of norepinephrine within the locus coeruleus

    • C. 

      The release of dopamine within the lateral hypothalamus

    • D. 

      Inactivation of frontal cortex

    • E. 

      Activation of the medulla


  • 9. 
    Imagine that you have ingested a drug that prevents alcohol from binding to the GABA/A receptor just before you join friends at a bar. Which of the following would you expect to happen to you?
    • A. 

      You show no signs of sedation, even after nine beers

    • B. 

      One beer puts you to sleep

    • C. 

      The pill makes the alcohol taste bitter, causing you to vomit

    • D. 

      You find alcohol more intoxicating

    • E. 

      You have impaired cerebellar function


  • 10. 
    PET studies show that schizophrenic patients treated with amphetamine show ______ from the striatum and a corresponding ________
    • A. 

      Reduced release of dopamine, increase in positive symptoms

    • B. 

      Reduced release of GABA, decrease in positive symptoms

    • C. 

      Greater release of dopamine, decrease in negative symptoms

    • D. 

      Greater release of dopamine, increase in positive symptoms

    • E. 

      Reduced release of serotonin, increase in negative symptoms


  • 11. 
    John has been diagnosed with schizophrenia and has shown improvement in positive symptoms while taking chlorpromazine.  Which of the following actions below, if taken by John, would be expected to greater worsen his positive schizophrenia symptoms?
    • A. 

      John stops taking CPZ and takes cocaine

    • B. 

      John takes double the CPZ dose per day

    • C. 

      John takes reserpine in addition to CPZ

    • D. 

      John mixes alcohol with CPZ

    • E. 

      John ingests alpha-methyl-para-tyrosine in addition to CPZ


  • 12. 
    Alternating episodes of elation and sadness are referred to as
    • A. 

      Bipolar disorder

    • B. 

      Severe depression

    • C. 

      Severe mania

    • D. 

      Unipolar depression

    • E. 

      Schizoaffective disorder


  • 13. 
    The function of monoamine oxidase is to  
    • A. 

      Provide the precursor for the catecholamines

    • B. 

      Convert dopamine into norepinephrine

    • C. 

      Convert norepinephrine into epinephrine

    • D. 

      Convert catecholamines and serotonin into inactive forms

    • E. 

      Speed up the digestion of cheese in the gut


  • 14. 
    The monoamine hypothesis states that depression is caused by
    • A. 

      Loss of cells in the prefrontal cortex

    • B. 

      Insufficient activity of monoaminergic neurons

    • C. 

      Excessive activity of dopamine systems

    • D. 

      Overactivity of monoaminergic neurons

    • E. 

      Excessive activity of serotonin synapses


  • 15. 
    All of the following support the monoamine hypothesis of depression EXCEPT  
    • A. 

      Reserpine causes depression

    • B. 

      CSF levels of 5-HIAA are low in suicidal patients

    • C. 

      Monoamine agonists produce depression

    • D. 

      Families of subjects with low 5-HIAAA were more likely to include people with depression

    • E. 

      Monoamine antogonists produce depression


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