Quiz 2: DNA Damage, Repair And Recombination

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 quiz 2: DNA damage,repair and recombination
Section F – DNA damage, repair and recombination F1 Mutagenesis F2 DNA damage F3 DNA Repair F4 Recombination ACARA PRESENTASI KELOMPOK, Selasa, 18 Mei 20101. Presenter Kelompok 3 (Penyanggah Kelompok 5): Topik Mutations2. Presenter Kelompok 4 (Penyanggah Kelompok 6): Topik DNA Repair

  
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  • 1. 
    Which of the following is TRUE about mutation
    • A. 

      Acceptable variations in the ‘normal’ DNA and protein sequences

    • B. 

      The exchange of DNA between chromosomes during meiosis.

    • C. 

      The movement of a ribosome from one reading frame to another at an internal position within a gene

    • D. 

      A DNA repair process that corrects various types of DNA damage by excising and resynthesizing a region of polynucleotide

    • E. 

      Permanent, heritable alterations in the base sequence of the DNA.


  • 2. 
    Mutations arise through spontaneous__________ I. in DNA replication II. in meiotic recombination III. as a consequence of the damaging effects of physical or chemical agents on the DNA
    • A. 

      I only

    • B. 

      II only

    • C. 

      III only

    • D. 

      I and II

    • E. 

      I, II, and III


  • 3. 
    An alteration in a nucleotide sequence that changes a triplet coding for an amino acid into a termination codon.
    • A. 

      Nonsense mutation

    • B. 

      Mutation

    • C. 

      Mutagenesis

    • D. 

      Mutagen

    • E. 

      Missense mutation


  • 4. 
    A point mutation that replaces a purine with another purine, or a pyrimidine with another pyrimidine.
    • A. 

      Transition

    • B. 

      Transversion

    • C. 

      Nonsense

    • D. 

      Silent mutation

    • E. 

      Missense mutation


  • 5. 
    A point mutation that involves a purine being replaced by a pyrimidine, or vice versa.
    • A. 

      Transition

    • B. 

      Transversion

    • C. 

      Nonsense

    • D. 

      Silent mutation

    • E. 

      Missense mutation


  • 6. 
    A change in a DNA sequence that has no effect on the expression or functioning of any gene or gene product.
    • A. 

      Transition

    • B. 

      Transversion

    • C. 

      Nonsense

    • D. 

      Silent mutation

    • E. 

      Missense mutation


  • 7. 
    An alteration in a nucleotide sequence that converts a codon for one amino acid into a codon for a second amino acid.
    • A. 

      Transition

    • B. 

      Transversion

    • C. 

      Nonsense

    • D. 

      Silent mutation

    • E. 

      Missense mutation


  • 8. 
    The frameshift mutations in genes can be produced by _________ I. transition II. deletetion III. insertion
    • A. 

      I only

    • B. 

      II only

    • C. 

      III only

    • D. 

      I and II

    • E. 

      II and III


  • 9. 
    An alteration to the normal chemical or physical structure of the DNA.
    • A. 

      Transition

    • B. 

      Transversion

    • C. 

      Nonsense

    • D. 

      Lesion

    • E. 

      Missense mutation


  • 10. 
    5-Bromouracil is an analog of ___________ that can react with deoxyribonucleic acid to produce a polymer with increased susceptibility to mutation.
    • A. 

      Thymine

    • B. 

      Guanine

    • C. 

      Cytosine

    • D. 

      Uracil

    • E. 

      Adenine


  • 11. 
    Cyclobutane pyrimidine dimers can be monomerized again by ________ in the presence of visible light.
    • A. 

      Exonuclease

    • B. 

      DNA photolyases

    • C. 

      Transposase

    • D. 

      DNA polymerase

    • E. 

      Integrase


  • 12. 
    All transposons encode a _________ which catalyzes the insertion.
    • A. 

      DNA glycosylase

    • B. 

      Excisionase

    • C. 

      Transposase

    • D. 

      DNA polymerase

    • E. 

      Integrase


  • 13. 
    Small DNA sequences that can move to virtually any position in a cell’s genome.
    • A. 

      Exons

    • B. 

      Introns

    • C. 

      Egulons

    • D. 

      LTRs

    • E. 

      Transposons


  • 14. 
    In base excision repair, the lesion is removed by __________
    • A. 

      DNA glycosylase

    • B. 

      Excisionase

    • C. 

      Transposase

    • D. 

      DNA polymerase

    • E. 

      Integrase


  • 15. 
    In nucleotide excision repair, an endonuclease makes nicks on either side of the lesion, which is then removed to leave a gap.  This gap is filled by __________ to makes the final phosphodiester bond. I.DNA polymerase II.DNA ligase III. DNA glycolase
    • A. 

      I only

    • B. 

      II only

    • C. 

      III only

    • D. 

      I and II

    • E. 

      I, II, and III


  • 16. 
    Which of the following common examples of alkylating agents.
    • A. 

      Methylmethane sulfonate (MMS)

    • B. 

      Ethylnitrosourea (ENU)

    • C. 

      Nitrous acid

    • D. 

      A and B

    • E. 

      A, B, and C


  • 17. 
    The exchange of nonhomologous regions of DNA at specific sites is independent of _________
    • A. 

      IS elements

    • B. 

      Illegitimate recombination

    • C. 

      Retrotransposons

    • D. 

      RecA

    • E. 

      General recombination


  • 18. 
    The dispersed repetitive sequences found in higher eukaryotic DNA (e.g. LINES and SINES) probably spread through the genome by _________
    • A. 

      Transposition

    • B. 

      Homologous recombination

    • C. 

      Site-specific recombination

    • D. 

      Replication

    • E. 

      General recombination


  • 19. 
    The enzyme of Escherichia coli is a nuclease that initiates the repair of double-stranded DNA breaks by homologous recombination.
    • A. 

      RNA polymerase

    • B. 

      DNA polymerase

    • C. 

      DNA ligase

    • D. 

      RecBCD

    • E. 

      DNA glycolase


  • 20. 
    Which of the following DNA mutation that result in the appearance of a stop codon in the resulting mRNA. synthesis.
    • A. 

      Transition

    • B. 

      Transversion

    • C. 

      Nonsense

    • D. 

      Silent mutation

    • E. 

      Missense mutation


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