Pharm Mt 1 Part IV
Principles of Pharm (pgs. 26-39; skipped 31-35)
- 1.
What detemerines whether an agonist is strong or weak?
- 2.
What is the conversion from lbs to kg?
- 3.
Briefly describe the 4 categories involved int he FDA Pregnancy Risk Factor Categories.
- 4.
Which of the drug monograph sections should an OD review o find info on the half life, onset of action, binding mechanism and elimination?
- A.
Indications
- B.
Mech of action
- C.
Pharmacokinetics/dynamics
- D.
Administration
Correct Answer
C. Pharmacokinetics/dynamicsExplanation
question from lectureRate this question:
-
- 5.
The SCr is a _____ sensitive indicator of renal function than the BUN.
Correct Answer
moreExplanation
pg. 26Rate this question:
- 6.
What category for Pregnancy Risk Factors is a contra-indication in women who are or may become pregnant?
- A.
A
- B.
C
- C.
D
- D.
X
- E.
Both options C and D
Correct Answer
D. XExplanation
pg. 37Rate this question:
-
- 7.
Which of the following is NOT involved in the hepatobiliary excretion process?
- A.
Liver
- B.
Bile
- C.
Gall bladder
- D.
None of the above (all are involved)
Correct Answer
D. None of the above (all are involved)Explanation
liver --> gall bladder --> bile --> feces
pg. 26Rate this question:
-
- 8.
Use of actual body weight in obese patients may significanly _______ CrCl.
Correct Answer
overestimateExplanation
In obese patients, need to use adujusted body weight (ABW) instead when calculating CrCl and doses.
pg. 26Rate this question:
- 9.
High doses of agonists can overcome non-competitive antagonism.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
non-competitive antagonism: antagonist binds to sites OTHER THAN the agonist-binding domain
pg. 29Rate this question:
-
- 10.
Renal dose adjustments are not usually needed unless the CrCl is less than ____mL/min.
- A.
10
- B.
25
- C.
50
- D.
65
Correct Answer
C. 50Explanation
Some drugs do not need to be adjusted until the clearance is lower..
pg. 27Rate this question:
-
- 11.
DNA transcription, steroid production, stimulation of red blood production are all examples of what type of event in response to drug binding to receptor sites?
- A.
Activation of cellular function
- B.
Inhibition of cellular function
- C.
Activation of biochemical processes
- D.
Opening or closing of ionic channels
Correct Answer
A. Activation of cellular functionExplanation
pg. 28Rate this question:
-
- 12.
The creatinine clearance of a female is what percent of a males?
- A.
55%
- B.
65%
- C.
75%
- D.
85%
Correct Answer
D. 85%Explanation
pg.26Rate this question:
-
- 13.
How strongly a drug molecule binds to a binding site is referred to as:
- A.
Binding strength
- B.
Affiliation
- C.
Affinity
- D.
Affixation
Correct Answer
C. AffinityExplanation
pg. 28
The dissociation constant (K sub D) describes the degree of a drug's affinity for the receptor site. This is the concentration of drug in solution necessary for 50% of given receptors to be occupied (pg. 29)Rate this question:
-
- 14.
________ is a concept often used when comparing the effects in the same class of drugs.
- A.
Irreversible antagonism
- B.
Drug efficiency
- C.
Drug efficacy
- D.
Drug potency
Correct Answer
D. Drug potencyExplanation
-vs-
Drug efficacy: used when comparing the effects od drugs in DIFFERENT classes or which have different mechs of
pg. 29Rate this question:
-
- 15.
Where do agonists bind?
- A.
Intracellular receptors
- B.
Plasma membranes
- C.
Nuclear membranes
- D.
All of the above
- E.
More than one of the above
Correct Answer
E. More than one of the aboveExplanation
agonists are drugs which change or affect cellular physiology by binding to INTRACELLULAR RECEPTORS or PLASMA MEMBRANES
(pg. 29)Rate this question:
-
- 16.
What drug info monograph section should an OD review in order to find info on how the drug actually works?
- A.
Indications
- B.
Mechanism of action
- C.
Pharmakodynamics
- D.
Dosage
Correct Answer
B. Mechanism of actionExplanation
question from lectureRate this question:
-
- 17.
The margin between the therapeutic dose and the lethal dose of a drug is termed _____.
- A.
Therapeutic index
- B.
Lethal index
- C.
Margin of safety
- D.
Margin of death
Correct Answer
C. Margin of safetyExplanation
pg. 30Rate this question:
-
- 18.
High doses of agnosits can overcome competitive antagonism.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
Competitive antagonism: antagonist competes with agonists for receptor site
pg. 29Rate this question:
-
- 19.
The amount of drug required to produce 50% of the maximal response that the drug is capable of inducing is the definition for ___________.
Correct Answer
drug potency - 20.
What Pregnancy Risk Factor Category corresponds to a drug that has no animal or female studies available to determine risks.
- A.
A
- B.
B
- C.
C
- D.
D
- E.
X
Correct Answer
C. CExplanation
pg. 37Rate this question:
-
Quiz Review Timeline +
Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.
-
Current Version
-
Mar 20, 2022Quiz Edited by
ProProfs Editorial Team -
Dec 11, 2011Quiz Created by
Tseemore
Back to top