Steroids (MSQ DRILL 171)

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1/39 Questions

During a stressful situation is cortisol upregulated or downregulated?
- Upregulated
- Downregulated

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2.

What is the best time to administer cortisol so that the hypothalamic pituitary axis is not suppressed.
- AM
- PM
Correct Answer

A. AM
3.

The following drugs are all intermediate to long acting gluccocorticoids. Which one is most often used for CNS penetration?
- Triamnicolone (kenalog)
- Bethamethasone (diprosone)
- Dexamethasone
Correct Answer

A. Dexamethasone
4.

Can corticosteroids cause acne?
- Yes
- No
Correct Answer

A. Yes
5.

Which part of the adrenal gland produces epinephrine and norpeinephrine?
- Medulla
- Cortex
Correct Answer

A. Medulla
6.

The production of cortisol/sorticosteroids is highest in the AM or PM?
- AM
- PM
Correct Answer

A. AM
7.

Does cortisol cause a negative feedbacm inhibition of the hypothalamic and pituitary activity?
- Yes
- No
Correct Answer

A. Yes
8.

Is cortisol metabolism CYP dependant?
- Yes
- No
Correct Answer

A. Yes

Explanation

Inducers will lead to a need to increase the amount of cortisol.

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9.

So, late phase adrenal suppression occurs at the glucocorticoid receptor?
- Yes
- No
Correct Answer

A. Yes
10.

What effect does the mineralocorticoid receptor have on sodium?
- Decreases Na+ leading to diuresis, hypovolemia and hypotension
- Increases Na+ leading to retention, hypervolemia and hypertension
Correct Answer

A. Increases Na+ leading to retention, hypervolemia and hypertension
11.

How do we prevent HPA suppression in a patient that has been taking corticosteroids for >7 days?
- Stop the medication suddenly in order to drop the levels
- Taper the medication
Correct Answer

A. Taper the medication
12.

Normal non-stresed individuals will produce _______ of cortisol. Stressed individuals will produce up to 200mg/24hrs.
- 5mg
- 10-30mg
- 100mg
- 150mg
Correct Answer

A. 10-30mg
13.

Aldosterone or minerlocorticoid is produced in the glomerulosa. True or false?
- True
- False
Correct Answer

A. True
14.

A patient has an abnormally high level of adrenocroticotropic hormone (ACTH), measuring the CRF will confirm that the pituitary gland is the source of the abnormality. True or false?
- True
- False
Correct Answer

A. True

Explanation

The hypothalamus releases CRF in response to the pituitary gland.

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15.

Does mineralocorcoid cause K+ loss or retention?
- K+ loss
- K+ retention
Correct Answer

A. K+ loss
16.

Taking a gluccocrticoid will increase blood sugar levels. True or false?
- Yes, this is due to insulin antagonism
- No, it has no effect on blood suar levels
Correct Answer

A. Yes, this is due to insulin antagonism
17.

What is aldosterone?
- Mineralocorticoid
- Glucocorticoid
- Gonadocroticoid
Correct Answer

A. Mineralocorticoid
18.

If a patient is taking steroids chronically and then they experience increased stress, will their dose need to be increased or decreased?
- Increased
- Decreased
Correct Answer

A. Increased
19.

Does a short term increase of cortisol result in feedback inhibition?
- Yes
- No
Correct Answer

A. No
20.

Which receptor has more affinity for cortisol, the mineralocorticoid receptor or the gluccocorticoid receptor?
- Mineralocorticoid receptor
- Gluccocorticoid receptor
Correct Answer

A. Mineralocorticoid receptor
21.

Fludrocortisone (florinef) is primarily a :
- Glucocorticoid
- Mineralocorticoid
- Gonadocorticoid
Correct Answer

A. Mineralocorticoid
22.

Methylprednisolone is:
- Primarily mineralocorticoid
- Mixed
- Primary glucorcorticoid and short acting
Correct Answer

A. Primary glucorcorticoid and short acting
23.

The maximum stress induced production of cortisol is approximately ______ over 7-10 days.
- 50mg/24hr
- 100.mg/24hr
- 150mg/24hr
- 200mg/24hr
- 250mg/24hr
Correct Answer

A. 200mg/24hr
24.

The ____________ releases corticotropin releasing factor when cortisol level is low.
- Hypothalamus
- Pituitary gland
- Adrenal gland
Correct Answer

A. Hypothalamus
25.

Where does initial suppression of the HPA axis start?
- Mineralocorticoid receptor
- Gluccocorticoid receptor
Correct Answer

A. Mineralocorticoid receptor
26.

Glucocorticoids are involved in the following functions>
- Gluconeogenesis
- Protein anabolism
- Protein catabolism
- Lipolysis
Correct Answer(s)

A. Gluconeogenesis
A. Protein catabolism
A. Lipolysis
27.

Above suprophysiologc doses cortisol will cuase feedback inhibition. What is considered a suproaphyisiologic dose of cortisol?
- >20mg hydrocortison/day
- >30mg hydrocortisone/day
- >40mg hydrocortisone/day
Correct Answer

A. >20mg hydrocortison/day
28.

Gluccocorticoids are produced in the:
- Glomerulosa
- Fasciculata
- Reticularis
Correct Answer

A. Fasciculata
29.

Which of the following is/are produce in the reticularis
- Aldosterone
- Gonadocorticoids
Correct Answer

A. Gonadocorticoids
30.

If adrenocorticosteroids are low, the pituitary gland releases ACTH which will cause an increased production of adrenocroticosteroids by the:
- Adrenal medulla
- Adrenal cortex
Correct Answer

A. Adrenal cortex
31.

Hydrocortisone, cortisone and prednisone are:
- Primarily mineralocorticoid
- Mixed
- Primarily glococorticoid
Correct Answer

A. Mixed
32.

Glucocorticoid also have the following functions:
- Anti inflammatory
- Decreased anti body production & cytokines
- Decreased WBC margination (leukocytosis)
- Decreased COX 2 expression
- Increased apoptosis in neoplams
Correct Answer(s)

A. Anti inflammatory
A. Decreased anti body production & cytokines
A. Decreased WBC margination (leukocytosis)
A. Decreased COX 2 expression
A. Increased apoptosis in neoplams
33.

Gluccorcoticoids cause insuloin antagonism, therefore there is more circulating blood sugar leading to more fat deposition or redistribution of fat. What are common names used to describe this phenomenon?
- Moon face
- Buffalo hump
- Cauliflower ears
- Cushingoid
Correct Answer(s)

A. Moon face
A. Buffalo hump
A. Cushingoid
34.

The adrenal cortex produces adrenal corticosteroids. Namely these are:
- Aldosterone
- Glucocorticoids
- Gonadocorticoids
- Mineralocorticoid
- Prednisone
Correct Answer(s)

A. Aldosterone
A. Glucocorticoids
A. Gonadocorticoids
A. Mineralocorticoid

Explanation

mineralocorticoid is aldosterone.

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35.

Which of the following are involved in the hypothalamic-pituitary-adrenal axis?
- Corticotropin releasing factor (CRF)
- Adrenocorticotropic hormone
- Cortisol
- Thyroid stimulating hormone
Correct Answer(s)

A. Corticotropin releasing factor (CRF)
A. Adrenocorticotropic hormone
A. Cortisol
36.

Do corticosteroids cause sedation?
- Yes, they can cuse sedation
- No, they actually cause agitation
Correct Answer

A. No, they actually cause agitation
37.

Adrenocorticotropic hormone is released by the pituitary gland. It also causes an increase in mealnin production and hyperpigmentation. When it does this is it acting as _________ .
- Melanin
- Melatonin
- A melanocortin
Correct Answer

A. A melanocortin

Explanation

This explains why patients with primary Addison's disease have hyperpigmentation.

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38.

Which of the following are ACUTE sie effcts of corticosteroids?
- Hypoerglycemia
- Hypokalemia
- Psychois/depression/euphoria
- Increased risk of infection and superinfection
- Decreased appetitie
Correct Answer(s)

A. Hypoerglycemia
A. Hypokalemia
A. Psychois/depression/euphoria
A. Increased risk of infection and superinfection
A. Decreased appetitie

Explanation

Appetite if increased.

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39.

Chronic side effects of corticosteroids incude:
- Poor wound healing
- Glaucoma & osteoporosis
- Cushingoid appearance and striae
- Weight gain and gastric erosion
- HPA suppression
Correct Answer(s)

A. Poor wound healing
A. Cushingoid appearance and striae
A. Weight gain and gastric erosion
A. HPA suppression

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Current Version
Feb 16, 2019

Quiz Edited by
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Apr 28, 2010

Quiz Created by

Steroids (Msq Drill 171)

During a stressful situation is cortisol upregulated or downregulated?

Quiz Preview

What is the best time to administer cortisol so that the hypothalamic pituitary axis is not suppressed.

The following drugs are all intermediate to long acting gluccocorticoids. Which one is most often used for CNS penetration?

Can corticosteroids cause acne?

Which part of the adrenal gland produces epinephrine and norpeinephrine?

The production of cortisol/sorticosteroids is highest in the AM or PM?

Does cortisol cause a negative feedbacm inhibition of the hypothalamic and pituitary activity?

Is cortisol metabolism CYP dependant?

So, late phase adrenal suppression occurs at the glucocorticoid receptor?

What effect does the mineralocorticoid receptor have on sodium?

How do we prevent HPA suppression in a patient that has been taking corticosteroids for >7 days?

Normal non-stresed individuals will produce _______ of cortisol. Stressed individuals will produce up to 200mg/24hrs.

Aldosterone or minerlocorticoid is produced in the glomerulosa. True or false?

A patient has an abnormally high level of adrenocroticotropic hormone (ACTH), measuring the CRF will confirm that the pituitary gland is the source of the abnormality. True or false?

Does mineralocorcoid cause K+ loss or retention?

Taking a gluccocrticoid will increase blood sugar levels. True or false?

What is aldosterone?

If a patient is taking steroids chronically and then they experience increased stress, will their dose need to be increased or decreased?

Does a short term increase of cortisol result in feedback inhibition?

Which receptor has more affinity for cortisol, the mineralocorticoid receptor or the gluccocorticoid receptor?

Fludrocortisone (florinef) is primarily a :

Methylprednisolone is:

The maximum stress induced production of cortisol is approximately ______ over 7-10 days.

The ____________ releases corticotropin releasing factor when cortisol level is low.

Where does initial suppression of the HPA axis start?

Glucocorticoids are involved in the following functions>

Above suprophysiologc doses cortisol will cuase feedback inhibition. What is considered a suproaphyisiologic dose of cortisol?

Gluccocorticoids are produced in the:

Which of the following is/are produce in the reticularis

If adrenocorticosteroids are low, the pituitary gland releases ACTH which will cause an increased production of adrenocroticosteroids by the:

Hydrocortisone, cortisone and prednisone are:

Glucocorticoid also have the following functions:

Gluccorcoticoids cause insuloin antagonism, therefore there is more circulating blood sugar leading to more fat deposition or redistribution of fat. What are common names used to describe this phenomenon?

The adrenal cortex produces adrenal corticosteroids. Namely these are:

Which of the following are involved in the hypothalamic-pituitary-adrenal axis?

Do corticosteroids cause sedation?

Adrenocorticotropic hormone is released by the pituitary gland. It also causes an increase in mealnin production and hyperpigmentation. When it does this is it acting as _________ .

Which of the following are ACUTE sie effcts of corticosteroids?

Chronic side effects of corticosteroids incude: