Steroids (Msq Drill 171)

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1. During a stressful situation is cortisol upregulated or downregulated?
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2. What is the best time to administer cortisol so that the hypothalamic pituitary axis is not suppressed.
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3. The following drugs are all intermediate to long acting gluccocorticoids. Which one is most often used for CNS penetration?
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4. Can corticosteroids cause acne?
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5. Which part of the adrenal gland produces epinephrine and norpeinephrine?
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6. The production of cortisol/sorticosteroids is highest in the AM or PM?
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7. Does cortisol cause a negative feedbacm inhibition of the hypothalamic and pituitary activity?
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8. Is cortisol metabolism CYP dependant?

Explanation

Inducers will lead to a need to increase the amount of cortisol.

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9. So, late phase adrenal suppression occurs at the glucocorticoid receptor?
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10. What effect does the mineralocorticoid receptor have on sodium?
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11. How do we prevent HPA suppression in a patient that has been taking corticosteroids for >7 days?
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12. Normal non-stresed individuals will produce _______ of cortisol. Stressed individuals will produce up to 200mg/24hrs.
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13. Aldosterone or minerlocorticoid is produced in the glomerulosa. True or false?
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14. A patient has an abnormally high level of adrenocroticotropic hormone (ACTH), measuring the CRF will confirm that the pituitary gland is the source of the abnormality. True or false?

Explanation

The hypothalamus releases CRF in response to the pituitary gland.

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15. Does mineralocorcoid cause K+ loss or retention?
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16. Taking a gluccocrticoid will increase blood sugar levels. True or false?
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17. What is aldosterone?
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18. If a patient is taking steroids chronically and then they experience increased stress, will their dose need to be increased or decreased?
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19. Does a short term increase of cortisol result in feedback inhibition?
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20. Which receptor has more affinity for cortisol, the mineralocorticoid receptor or the gluccocorticoid receptor?
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21. Fludrocortisone (florinef) is primarily a :
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22. Methylprednisolone is:
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23. The maximum stress induced production of cortisol is approximately ______ over 7-10 days.
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24. The ____________ releases corticotropin releasing factor when cortisol level is low.
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25. Where does initial suppression of the HPA axis start?
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26. Glucocorticoids are involved in the following functions>
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27.
Above suprophysiologc doses cortisol will cuase feedback inhibition. What is considered a suproaphyisiologic dose of cortisol?
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28. Gluccocorticoids are produced in the:
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29. Which of the following is/are produce in the reticularis
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30. If adrenocorticosteroids are low, the pituitary gland releases ACTH which will cause an increased production of adrenocroticosteroids by the:
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31. Hydrocortisone, cortisone and prednisone are:
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32. Glucocorticoid also have the following functions:
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33. Gluccorcoticoids cause insuloin antagonism, therefore there is more circulating blood sugar leading to more fat deposition or redistribution of fat. What are common names used to describe this phenomenon?
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34. The adrenal cortex produces adrenal corticosteroids. Namely these are:

Explanation

mineralocorticoid is aldosterone.

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35. Which of the following are involved in the hypothalamic-pituitary-adrenal axis?
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36. Do corticosteroids cause sedation?
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37. Adrenocorticotropic hormone is released by the pituitary gland. It also causes an increase in mealnin production and hyperpigmentation. When it does this is it acting as  _________ .

Explanation

This explains why patients with primary Addison's disease have hyperpigmentation.

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38. Which of the following are ACUTE sie effcts of corticosteroids?

Explanation

Appetite if increased.

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39. Chronic side effects of corticosteroids incude:
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During a stressful situation is cortisol upregulated or downregulated?
What is the best time to administer cortisol so that the hypothalamic...
The following drugs are all intermediate to long acting...
Can corticosteroids cause acne?
Which part of the adrenal gland produces epinephrine and...
The production of cortisol/sorticosteroids is highest in the AM or PM?
Does cortisol cause a negative feedbacm inhibition of the hypothalamic...
Is cortisol metabolism CYP dependant?
So, late phase adrenal suppression occurs at the glucocorticoid...
What effect does the mineralocorticoid receptor have on sodium?
How do we prevent HPA suppression in a patient that has been taking...
Normal non-stresed individuals will produce _______ of cortisol....
Aldosterone or minerlocorticoid is produced in the glomerulosa. True...
A patient has an abnormally high level of adrenocroticotropic hormone...
Does mineralocorcoid cause K+ loss or retention?
Taking a gluccocrticoid will increase blood sugar levels. True or...
What is aldosterone?
If a patient is taking steroids chronically and then they experience...
Does a short term increase of cortisol result in feedback inhibition?
Which receptor has more affinity for cortisol, the mineralocorticoid...
Fludrocortisone (florinef) is primarily a :
Methylprednisolone is:
The maximum stress induced production of cortisol is approximately...
The ____________ releases corticotropin releasing factor when cortisol...
Where does initial suppression of the HPA axis start?
Glucocorticoids are involved in the following functions>
Above suprophysiologc doses cortisol will cuase feedback inhibition....
Gluccocorticoids are produced in the:
Which of the following is/are produce in the reticularis
If adrenocorticosteroids are low, the pituitary gland releases ACTH...
Hydrocortisone, cortisone and prednisone are:
Glucocorticoid also have the following functions:
Gluccorcoticoids cause insuloin antagonism, therefore there is more...
The adrenal cortex produces adrenal corticosteroids. Namely these are:
Which of the following are involved in the...
Do corticosteroids cause sedation?
Adrenocorticotropic hormone is released by the pituitary gland. It...
Which of the following are ACUTE sie effcts of corticosteroids?
Chronic side effects of corticosteroids incude:
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