Saving Lives With Antibody Titer Tests

1. The following types of tests are used to measure protective immunity after vaccination with certain of the vaccine viruses:

Virus neutralization (VN)

Hemagglutination inhibition (HI)

Enzyme linked immunosorbent assay (ELISA)

(a), (b) and (c)

None of the above

2. Why are titers not routinely used for CDV and CPV in lieu of revaccination?

They are often too expensive

Titers are poorly understood

It is easier to revaccinate than have a titer performed

(a), (b) and (c)

They do not correlate with immunity

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4. Antibody plays a critical role in protective immunity for the following canine diseases:

Canine distemper

Canine parvovirus

Canine adenovirus

Rabies virus

All of the above

5. When a shelter is having a CDV outbreak, how can titers be used to control the outbreak?

Only allow dogs over 16 to 20 weeks of age with antibody to enter the shelter or the part of the shelter where the outbreak is present

Keep puppies less than 16 to 20 weeks out of the shelter when possible, regardless of antibody status

Dogs already in the shelter over 16 to 20 weeks that have been vaccinated and have antibody can remain

Do not send dogs for adoption/fostering that have been in the shelter and are antibody neg

All of the above

6. An antibody positive test, when used to measure antibody to CDV in a one year old dog that has never been vaccinated, shows that:

The dog has maternally derived antibody (MDA)

The dog is immune to CDV

The dog was apparently naturally infected, with or without disease signs and is immune

Both (b) and (c)

None of the above are correct

7. If you were given the following options, which would you choose for a dog that has received its puppy vaccines and has returned for its one year exam?

Revaccinate the animal with CDV/CPV/CAV

Perform an antibody test for CDV/CPV/CAV

Perform an antibody test, then revaccinate if it shows the animal is not immune

A and B

None of the above

8. Why can't antibody titers be used to control outbreaks of canine and feline infectious respiratory disease complex (aka Kennel Cough, Upper Respiratory Infections)?

Serum titers to mucosal pathogens don’t correlate with protection

These diseases are caused by multiple microbial agents and other factors

These diseases are not vaccine preventable, thus titers are of limited value

All of the above

There are no tests available to measure antibody to the pathogens causing these disorders!

9. You should not use antibody tests to measure protective immunity from vaccination in:

Puppies less than 16 weeks of age

Kittens less than 16 weeks of age

Both (a) and (b)

Dogs and cats older than 15 years

Dogs or cats that have never been vaccinated

10. The titers for the above dog indicate that the real titer for CDV and CPV-2 are:

CDV titer is 32 to 128

CPV titer is 640 to 2560

The titers show the dog is immune

The titers show the dog did not need to be revaccinated with CDV or CPV to maintain titers

All of the above

11. You received a titer for CPV and CDV from the Diagnostic Lab from a dog that was vaccinated 8 years ago. The titer for CPV is 1280 and for CDV is 64. These results indicate the following:

The dog has antibody to the 2 viruses and is immune

The dog is more susceptible to CDV than CPV

The dog needs to be revaccinated with a product containing CDV and CPV

The dog is susceptible to CDV but not CPV

The dog has 20 times more antibody to CPV than CDV