Nsaids - Part 1 - Cox Enzyme Functions (Msq Drill 177)

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1/35 Questions

Eventually the prostaglandins form different tissue isomerase that play multiple roles in various tissues in the body. True or false?
- True
- False

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2.

Patients on NSAIDS are at risk for analagesic nephropathy. True or false?
- True
- False
Correct Answer

A. True
3.

Are prostaglandins also produced from arachidonic acid?
- Yes
- No
Correct Answer

A. Yes
4.

If one therefore blocks COX 1, the gastric mucosa will:
- Have an overwhelming supply of secretions
- Have no secretions and will thus erode
Correct Answer

A. Have no secretions and will thus erode
5.

If you give a patient a COX inhibitor with bother COX 1 and 2 effect, this will slow down or eliminate macrophage taxis. Will this lead to increased or decreased inflammation?
- Increased inflammation
- Decreased inflammation
Correct Answer

A. Decreased inflammation
6.

Therefore a patient can develop Acute renal failure due to NSAIDS. True or false?
- True
- False
Correct Answer

A. True
7.

COX 1 initiates the process that eventually leads to the production of ___________ which is responsible for platelet aggregation.
- Thromboxane A2
- Thromboxane B2
- Prostaglandin I2
- Prostaglanding E2
Correct Answer

A. Thromboxane A2
8.

Decreased renal afferent flow will lead to:
- Hyperperfusion of the kidneys
- Hypoperfusion of the kidneys
Correct Answer

A. Hypoperfusion of the kidneys
9.

Taking an NSAID will reduce perfusion into the kidneys. The kidneys respond by raising or lowering blood pressure?
- Raising blood pressure
- Lowering blood pressure
Correct Answer

A. Raising blood pressure
10.

Arachidonic acid is released from ______ .
- Leukotriennes
- Phospholipids
- Prostaglandin
- Cyclooxygenase
Correct Answer

A. Phospholipids

Explanation

Our cell membrane plays a role in the production of arachidonic acid.

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11.

Since prostaglandins can be manipulated by COX 1 and COX 2 to form various tissue isomerases. Which COX enzyme is responsible for maintaining the mucosa, facilitating cytoprotective secretions and increasing secretions?
- COX 1
- COX 2
Correct Answer

A. COX 1
12.

If all I wanted was an antipyretic effect from an NSAID then I would choose:
- A COX 1 inhibitor
- A COX 2 inhibitor
Correct Answer

A. A COX 2 inhibitor

Explanation

antipyretics - drugs that reduce fever

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13.

If you increased the dose of the COX inhibitor will the inflammation be even more reduced?
- Yes
- No
Correct Answer

A. Yes
14.

Which COX enzyme increases fever and also increases my sense of pain?
- COX 1
- COX 2
Correct Answer

A. COX 2

Explanation

COX 2 increased fever and also increases nocicpetion.

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15.

Do COX enzymes cause vasodilation or vasoconstriction?
- Vasodilation
- Vasoconstriction
Correct Answer

A. Vasodilation
16.

Are leukotrienes produced directly from phospholipids or from arachidonic acid?
- Leukotrienes are produced directly from phospholipase
- Leuknotrienes are produced from arachidonic acid
Correct Answer

A. Leuknotrienes are produced from arachidonic acid
17.

So, Aspirin has an effect on COX 1 or COX 2?
- Cox 1
- Cox 2
Correct Answer

A. Cox 1
18.

If you block COX enzymes by taking NSAIDs you increase or decrease leukotrienne formation?
- Increase
- Decrease
Correct Answer

A. Increase
19.

What do NSAIDS cause, an increase or decrease in pottasium?
- Pottassium gain
- Pottassium loss
Correct Answer

A. Pottassium loss
20.

Do both COX enzymes affect microphage chemotaxis?
- Yes
- No
Correct Answer

A. Yes
21.

One COX enzyme causes platelet aggregation whilst the other inhibits platelet aggregation. Which COX enzyme inhibits platelet aggregation?
- COX 1
- COX 2
Correct Answer

A. COX 2
22.

In general, COX enzymes perform the following functions on the kidney:
- Increase perfusion
- Maintain hydrostatic pressure
- Sodium secretion
- Control renin
- Aldosterone and potassium retention
Correct Answer(s)

A. Increase perfusion
A. Maintain hydrostatic pressure
A. Sodium secretion
A. Control renin
A. Aldosterone and potassium retention
23.

If you give a patient an NSAID, they will excrete more or less sodium?
- More sodium
- Less sodium
Correct Answer

A. Less sodium

Explanation

COX enzyme generally facilitate sodium excretion and potassium retention.

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24.

If COX enzymes cause vasodilation, what happens to renal afferent flow when a patient takes an NSAID?
- Increased renal afferent flow
- Decreased renal afferent flow
Correct Answer

A. Decreased renal afferent flow
25.

A physician is considering administering an NSAID to a woman in labor. Will this lead to a quicker delivery or an inhibition of the labor?
- Quicker delivery
- Inhibited labor
Correct Answer

A. Inhibited labor
26.

What enzyme facilitates the release of arachidonoc acid from phospholipase?
- Phospholipase A
- Phospholipase B
- Phospholipase C
Correct Answer

A. Phospholipase A
27.

What product of arachidonic acid plays a role in pulmonary inflammation and bronchconstriction and therefore has a role in the asthma?
- COX 1
- COX 2
- Prostaglandin 1
- Leukotrienne
- Thromboxane
Correct Answer

A. Leukotrienne
28.

Eventually patients on NSAIDs will have lower potassium levela and renal tubular _____ .
- Acidosis
- Alkalosis
Correct Answer

A. Acidosis
29.

COX 2 facilitates the production of ________ which is responsible for inhibiting platelet aggregation.
- Thromboxane B2
- Prostaglandin E2
- Prostaglandin I2
Correct Answer

A. Prostaglandin I2
30.

Which COX enzyme causes vasodilation and thus increased perfusion to the kidneys?
- COX 1
- COX 2
- Both COX 1 and COX 2
Correct Answer

A. Both COX 1 and COX 2
31.

What eznymes facilitates the prduction prostaglandins from arachidonic acid?
- COX 1
- COX 2
- Phospholipase B
Correct Answer(s)

A. COX 1
A. COX 2
32.

When a patient has an ulcer, their body probably uses COX _____ in the process of wound healing.
- COX 1
- COX 2
Correct Answer

A. COX 2
33.

What classes of antihypertensive medication should not be used concurrently with NSAIDS
- Diuretics
- Beta blockers
- Angiotensin convertine enzyme inhibitors (ACEIs)
- Angiotensin II receptor blockers (ARBs)
Correct Answer(s)

A. Angiotensin convertine enzyme inhibitors (ACEIs)
A. Angiotensin II receptor blockers (ARBs)
34.

Thus, increased leukotrienne formation will result in the following symptoms.
- Pulmonary inflammation
- Bronchospasms in those who are sensitive
- Anaphylactoid
- Bronchoconstriction
Correct Answer(s)

A. Pulmonary inflammation
A. Bronchospasms in those who are sensitive
A. Anaphylactoid

Explanation

anaphylactoid - resembling anaphylaxix

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35.

We have established that COX 2 causes platelet aggregation or thrombosis. IF you gave a patient Aspirin, will this thrombotic risk be decreased?
- Yes
- No
Correct Answer

A. No

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Quiz Edited by
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Apr 27, 2010

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Nsaids - Part 1 - Cox Enzyme Functions (Msq Drill 177)

Eventually the prostaglandins form different tissue isomerase that play multiple roles in various tissues in the body. True or false?

Quiz Preview

Patients on NSAIDS are at risk for analagesic nephropathy. True or false?

Are prostaglandins also produced from arachidonic acid?

If one therefore blocks COX 1, the gastric mucosa will:

If you give a patient a COX inhibitor with bother COX 1 and 2 effect, this will slow down or eliminate macrophage taxis. Will this lead to increased or decreased inflammation?

Therefore a patient can develop Acute renal failure due to NSAIDS. True or false?

COX 1 initiates the process that eventually leads to the production of ___________ which is responsible for platelet aggregation.

Decreased renal afferent flow will lead to:

Taking an NSAID will reduce perfusion into the kidneys. The kidneys respond by raising or lowering blood pressure?

Arachidonic acid is released from ______ .

Since prostaglandins can be manipulated by COX 1 and COX 2 to form various tissue isomerases. Which COX enzyme is responsible for maintaining the mucosa, facilitating cytoprotective secretions and increasing secretions?

If all I wanted was an antipyretic effect from an NSAID then I would choose:

If you increased the dose of the COX inhibitor will the inflammation be even more reduced?

Which COX enzyme increases fever and also increases my sense of pain?

Do COX enzymes cause vasodilation or vasoconstriction?

Are leukotrienes produced directly from phospholipids or from arachidonic acid?

So, Aspirin has an effect on COX 1 or COX 2?

If you block COX enzymes by taking NSAIDs you increase or decrease leukotrienne formation?

What do NSAIDS cause, an increase or decrease in pottasium?

Do both COX enzymes affect microphage chemotaxis?

One COX enzyme causes platelet aggregation whilst the other inhibits platelet aggregation. Which COX enzyme inhibits platelet aggregation?

In general, COX enzymes perform the following functions on the kidney:

If you give a patient an NSAID, they will excrete more or less sodium?

If COX enzymes cause vasodilation, what happens to renal afferent flow when a patient takes an NSAID?

A physician is considering administering an NSAID to a woman in labor. Will this lead to a quicker delivery or an inhibition of the labor?

What enzyme facilitates the release of arachidonoc acid from phospholipase?

What product of arachidonic acid plays a role in pulmonary inflammation and bronchconstriction and therefore has a role in the asthma?

Eventually patients on NSAIDs will have lower potassium levela and renal tubular _____ .

COX 2 facilitates the production of ________ which is responsible for inhibiting platelet aggregation.

Which COX enzyme causes vasodilation and thus increased perfusion to the kidneys?

What eznymes facilitates the prduction prostaglandins from arachidonic acid?

When a patient has an ulcer, their body probably uses COX _____ in the process of wound healing.

What classes of antihypertensive medication should not be used concurrently with NSAIDS

Thus, increased leukotrienne formation will result in the following symptoms.

We have established that COX 2 causes platelet aggregation or thrombosis. IF you gave a patient Aspirin, will this thrombotic risk be decreased?