Neuromuscular Junction Disorders (Msq Drill 187)

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1/23 Questions

What autoimmune disease leads to a loss of functional acetylocholine receptors at the neuromuscular junction due to autoantibodies against the acetycholine receptor?
- SLE
- Rheumatoid arthritis
- Myasthenia gravis
- Myositis

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2.

Can the weakness of MG become generalized?
- Yes
- No
Correct Answer

A. Yes
3.

60% of patients with Lambert-Eaton syndrome have:
- Breast cancer
- Small cell carcinoma of the lung
- Ovarian cancer
- Prostate cancer
Correct Answer

A. Small cell carcinoma of the lung
4.

Can Lambert-Eaton syndrome occur in the absence of a malignancy?
- Yes
- No
Correct Answer

A. Yes
5.

How does clostridium botulinum cause paralysis of respiraroty and sekeletal muscles?
- The clostridium botulinum blocks synaptic clefts
- The clostridium botulinum generates a neurotoxin that inhibits glutamate
- The clostridium botulinum generates a neurotoxin that inhibits the reuptake ot acetycholine
- The clostridium botulinum generates a neurotoxin that inhibits the release of acetylcholine.
Correct Answer

A. The clostridium botulinum generates a neurotoxin that inhibits the release of acetylcholine.
6.

Is clostridium botulinum the same agent that is used to treat wrinkles, migraines and torticollis in the form of botox?
- Yes
- No
Correct Answer

A. Yes
7.

Do patients with MG have constant weakness or does the weakness fluctuate?
- The weakness is constant
- The weakness fluctuates
Correct Answer

A. The weakness fluctuates
8.

Mortality in MG is usually due to:
- Falls
- Respiratory compromise
- Severe constipation
- Cardiac failure
Correct Answer

A. Respiratory compromise
9.

Symptoms of MG respond to the administration of what drugs?
- Acetaminophen
- Levadopa
- Acetycholinesterase inhibitors
- Simvastatin
Correct Answer

A. Acetycholinesterase inhibitors
10.

What is the causative agent of botulism?
- Clostridium difficile
- Clostridium perfringens
- Clostridium tetani
- Clostridium botulinum
Correct Answer

A. Clostridium botulinum
11.

65% of patients with myasthenia gravis have:
- Thymoma
- Thymic hyperplasia
Correct Answer

A. Thymic hyperplasia

Explanation

15% have thymoma

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12.

Patients with myasthenia gravis will initially have weakness of which muscles?
- Deltoid muscles
- Facial
- Extraocular
- Tongue
Correct Answer

A. Extraocular
13.

Will you find clostridium botulinum growing in adequately sterilized canned foods?
- Yes
- No
Correct Answer

A. No
14.

A 65 year old woman is found to have muscle weakness and antiacetylcholine receptor antibodies. What is the most likely diagnosis?
- Botulism
- Lambert-eaton syndrome
- Parkinson's disease
- Myasthenia gravis
- Alzheimer's disease
Correct Answer

A. Myasthenia gravis
15.

Lambert-Eaton syndrome is typically a ____________ process.
- Neoplastic
- Malignant
- Paraneoplastic
- Benign
Correct Answer

A. Paraneoplastic
16.

Clostridium botulinum is a gram _____ bacillus that grown in ______ conditions and produces spores.
- Positive, aerobic
- Negative aeorbic
- Positive, anerobic
- Negative, anerobic
Correct Answer

A. Negative, anerobic
17.

What is the prevalence of myasthenia gravis?
- 1/1000 000 people
- 3/100 000 people
- 3/100 000 people
Correct Answer

A. 3/100 000 people
18.

Which of the following are other uses of botox?
- Blepharospasm
- Hyperhydrosis
- Migraine
- Spasmodic torticollis
- Achalasia
Correct Answer(s)

A. Blepharospasm
A. Hyperhydrosis
A. Migraine
A. Spasmodic torticollis
A. Achalasia

Explanation

achalasia - esophageal aperilstalsis.

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19.

Which of the following are other forms of treatment for MG?
- Prednisone
- Plasmapheresis
- Resection of thymoma
- Azothioprine and cyclophosphamide
- Cyclosporine
Correct Answer(s)

A. Prednisone
A. Plasmapheresis
A. Resection of thymoma
A. Azothioprine and cyclophosphamide
A. Cyclosporine
20.

Patients with myasthenia gravis (MG) will exhibit weakness of their extraocular muscles leading to the following symptoms:
- Blindness
- Blurred vision
- Ptosis
- Diplopia
Correct Answer(s)

A. Ptosis
A. Diplopia
21.

Patients with Lambert-Eaton syndrome have abnormally low levels of acetylcholine in the neuromuscular junction synaptic vessels. True or false?
- True
- False
Correct Answer

A. False

Explanation

The acetylcholine content in the neuromuscular junction synaptic vessels is normal.

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22.

What is the most common type of pituitary adenoma?
- Prolactinoma
- Null cell
- Corticotropic
- Somatotropic
Correct Answer

A. Prolactinoma
23.

Since there is adequate Acetylcholine in the vesicles why is there less acetylcholine in the synapse?
- Fewer synaptic vessicles are released
- Patients have autoimunity to the presynaptic calcium channels
- Acetylcholine is degraded within the vessels
Correct Answer(s)

A. Fewer synaptic vessicles are released
A. Patients have autoimunity to the presynaptic calcium channels

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Feb 16, 2019

Quiz Edited by
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Apr 23, 2010

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Neuromuscular Junction Disorders (Msq Drill 187)

What autoimmune disease leads to a loss of functional acetylocholine receptors at the neuromuscular junction due to autoantibodies against the acetycholine receptor?

Quiz Preview

Can the weakness of MG become generalized?

60% of patients with Lambert-Eaton syndrome have:

Can Lambert-Eaton syndrome occur in the absence of a malignancy?

How does clostridium botulinum cause paralysis of respiraroty and sekeletal muscles?

Is clostridium botulinum the same agent that is used to treat wrinkles, migraines and torticollis in the form of botox?

Do patients with MG have constant weakness or does the weakness fluctuate?

Mortality in MG is usually due to:

Symptoms of MG respond to the administration of what drugs?

What is the causative agent of botulism?

65% of patients with myasthenia gravis have:

Patients with myasthenia gravis will initially have weakness of which muscles?

Will you find clostridium botulinum growing in adequately sterilized canned foods?

A 65 year old woman is found to have muscle weakness and antiacetylcholine receptor antibodies. What is the most likely diagnosis?

Lambert-Eaton syndrome is typically a ____________ process.

Clostridium botulinum is a gram _ bacillus that grown in __ conditions and produces spores.

What is the prevalence of myasthenia gravis?

Which of the following are other uses of botox?

Which of the following are other forms of treatment for MG?

Patients with myasthenia gravis (MG) will exhibit weakness of their extraocular muscles leading to the following symptoms:

Patients with Lambert-Eaton syndrome have abnormally low levels of acetylcholine in the neuromuscular junction synaptic vessels. True or false?

What is the most common type of pituitary adenoma?

Since there is adequate Acetylcholine in the vesicles why is there less acetylcholine in the synapse?

Neuromuscular Junction Disorders (Msq Drill 187)

What autoimmune disease leads to a loss of functional acetylocholine receptors at the neuromuscular junction due to autoantibodies against the acetycholine receptor?

Quiz Preview

Can the weakness of MG become generalized?

60% of patients with Lambert-Eaton syndrome have:

Can Lambert-Eaton syndrome occur in the absence of a malignancy?

How does clostridium botulinum cause paralysis of respiraroty and sekeletal muscles?

Is clostridium botulinum the same agent that is used to treat wrinkles, migraines and torticollis in the form of botox?

Do patients with MG have constant weakness or does the weakness fluctuate?

Mortality in MG is usually due to:

Symptoms of MG respond to the administration of what drugs?

What is the causative agent of botulism?

65% of patients with myasthenia gravis have:

Patients with myasthenia gravis will initially have weakness of which muscles?

Will you find clostridium botulinum growing in adequately sterilized canned foods?

A 65 year old woman is found to have muscle weakness and antiacetylcholine receptor antibodies. What is the most likely diagnosis?

Lambert-Eaton syndrome is typically a ____________ process.

Clostridium botulinum is a gram _____ bacillus that grown in ______ conditions and produces spores.

What is the prevalence of myasthenia gravis?

Which of the following are other uses of botox?

Which of the following are other forms of treatment for MG?

Patients with myasthenia gravis (MG) will exhibit weakness of their extraocular muscles leading to the following symptoms:

Patients with Lambert-Eaton syndrome have abnormally low levels of acetylcholine in the neuromuscular junction synaptic vessels. True or false?

What is the most common type of pituitary adenoma?

Since there is adequate Acetylcholine in the vesicles why is there less acetylcholine in the synapse?

Clostridium botulinum is a gram _ bacillus that grown in __ conditions and produces spores.