Hpmt 356- Immunology
Review quiz based on PPP for Microbiology Lecture 3- Immunology
- 1.
Which of the following does immunology deal with
- A.
The study of molecules, cells organs and systems responsible for the recognition and disposal of nonself material
- B.
How body components respond and interact
- C.
Desirable or undesirable consequences of immune interactions
- D.
How the immune system can be manipulated to protect against or treat disease
- E.
All of the above
Correct Answer
E. All of the above -
- 2.
Which of the following is not apart of the first line of defense
- A.
Skin and mucous membranes
- B.
Normal flora
- C.
Secretions
- D.
Antibodies
- E.
Defensins
Correct Answer
D. Antibodies -
- 3.
Which is not a part of the second line of defense
- A.
Phagocytosis
- B.
Complement
- C.
Secretions
- D.
Acute inflammatory reaction
- E.
Interferon and lysozome
Correct Answer
C. Secretions -
- 4.
Adaptive immunity is the ______line of defense
- A.
1st
- B.
2nd
- C.
3rd
Correct Answer
C. 3rd -
- 5.
Recognition, remembrance and response to a specific stimulus or antigen is not a part of
- A.
Specific/adaptive immunity
- B.
3rd line of defense
- C.
Innate or inborn resistance
- D.
Cell mediated immunity
- E.
Humoral immunity
Correct Answer
C. Innate or inborn resistance -
- 6.
Foreign substance capable of stimulating an immune response
- A.
Antigen
- B.
Antibody
Correct Answer
A. Antigen -
- 7.
Structure in the membrane or molecular component that the body recognizes as foreign
- A.
Epitope
- B.
Antigen determinants
- C.
All of the above
- D.
None of the above
Correct Answer
C. All of the above -
- 8.
Which of the following is not a goal of innate immunity
- A.
Recognize microbes encountered by host
- B.
Prevent infection of host
- C.
Initiate adaptive immune responses adjusted to invading microorganisms
- D.
Serve as effector mechanism for adaptive response
- E.
None of the above
Correct Answer
E. None of the above -
- 9.
Pattern recognitions receptors on cell membranes of phagocytic and other mammalian cells allow them to identify foreign cells. Which of the following is not a pattern recognition receptor
- A.
Toll-like receptor
- B.
Protein kinase r
- C.
Mannose receptor
- D.
Epitope
- E.
CD14
Correct Answer
D. EpitopeExplanation
epitope is a part of an antigen/ antigen determinantRate this question:
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- 10.
Often the innate immune system is able to destroy cancerous cells before they develop into more dangerous problems, this is an example of the innate immune system's ability to
- A.
Detect damaged tissue
- B.
Recognize self from nonself
- C.
Detect missing or changed self
- D.
All of the above
- E.
None of the above
Correct Answer
C. Detect missing or changed self -
- 11.
Innate immunity can do all of the following except
- A.
Increase production of antimicrobial peptides
- B.
Secretion of inflammatory mediators
- C.
Complement activation
- D.
Clotting cascade activation
- E.
None of the above
Correct Answer
E. None of the above -
- 12.
Acute phase reactant response is associated with
- A.
Increase in concentration of some proteins during inflammation
- B.
Disposal of waste
- C.
Opsonization
- D.
None of the above
Correct Answer
A. Increase in concentration of some proteins during inflammation -
- 13.
Complement received its name because it complements the action of antibodies
- A.
True
- B.
False
Correct Answer
A. True -
- 14.
Complement is most closely association with
- A.
Promotion of opsonization and lysis of foreign cells
- B.
Detection of self from nonself
- C.
Detection of damaged tissue
- D.
None of the above
Correct Answer
A. Promotion of opsonization and lysis of foreign cells -
- 15.
Complement is present in circulation in active form but can be inhibited by control proteins
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
complement circulates in inactive form and control proteins inhibit automatic activationRate this question:
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- 16.
Which of the following is not a function of complement
- A.
Host defense against infection
- B.
Interference between innate and adaptive immunity
- C.
Disposal of wastes
- D.
All of the above
- E.
None of the above
Correct Answer
E. None of the above -
- 17.
The classical pathway of complement activation is triggered by
- A.
Allergen, foreign substance, or lipopolysaccharide
- B.
Mannose on cell surface
- C.
Antigen/ antibody
- D.
All of the above
- E.
None of the above
Correct Answer
C. Antigen/ antibody -
- 18.
The alternate pathway of complement activation is triggered by
- A.
Contact with foreign surface
- B.
Antigen/antibody
- C.
Mannose
- D.
All of the above
- E.
None of the above
Correct Answer
A. Contact with foreign surface -
- 19.
Which is not true about the Mannose binding lectin pathway
- A.
Associated with MASP1 and MASP 2 protease
- B.
Activated by antigens/antibodies
- C.
Initiated by binding with mannose groups on bacterial cell surfaces
- D.
All of the above
- E.
None of the above
Correct Answer
B. Activated by antigens/antibodies -
- 20.
The three pathways of complement activation converge
- A.
Cleavage of C5 to C5b
- B.
Cleavage of C3 to C3b
- C.
Cleavage of Membrane attack complex
- D.
None of the above
Correct Answer
B. Cleavage of C3 to C3b -
- 21.
Once complement has been activated, enzyme activation occurs
- A.
True
- B.
False
Correct Answer
A. True -
- 22.
An overactive immune response can lead to
- A.
SIRS - severe inflammatory response syndrome
- B.
Septic shock
- C.
Death
- D.
All of the above
- E.
None of the above
Correct Answer
D. All of the above -
- 23.
Regarding changes in complement levels, which of the following is not true
- A.
Can lead to tissue damage
- B.
Can cause intravascular thrombosis
- C.
Can lead to infection or autoantibody
- D.
All of the above
- E.
None of the above
Correct Answer
E. None of the above -
- 24.
These are chemical messengers involved in all aspects of innate and adaptive immune response and includes Interferons, Chemokines, tissue necrosis factor, transforming growth factors and interleukins
Correct Answer
cytokines - 25.
Acute phase proteins such as c-reactive protein, C3 and C4 are specific indicators of inflammation
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
they are nonspecific indicators of inflammationRate this question:
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- 26.
Innate immunity is required for initiation of adaptive response
- A.
True
- B.
False
Correct Answer
A. True -
- 27.
Concerning antigen presenting cells, which statement is true
- A.
Macrophages and dendritic cells present to T cells
- B.
T cells present to macrophages and dendritic cells
- C.
Macrophages present to dendritic and T cells
- D.
Dendritic cells present to macrophages and T cells
- E.
None of the above
Correct Answer
A. Macrophages and dendritic cells present to T cells -
- 28.
B cells mature in the thymus and T cells mature in the bone marrow before release
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
B cells mature in bone marrow, and T cells mature in the thymusRate this question:
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- 29.
Antibodies are also known as
Correct Answer
immunoglobulins - 30.
Which does not describe antibodies/ immunoglobulins
- A.
Found in blood plasma and some body fluids
- B.
May need other agents like complement for bacteria
- C.
Includes IgM, IgG, IgA, IgD and IgE
- D.
Made of 2 heavy chains and 4 light chains with a variable and constant region
- E.
None of the above
Correct Answer
D. Made of 2 heavy chains and 4 light chains with a variable and constant regionExplanation
made of 2 light chains and 2 heavy chainsRate this question:
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- 31.
Name the correct antibody. Produced early in immune response, large molecule
Correct Answer
IgM - 32.
Name the correct antibody. Major Ig in normal serum, crosses placenta
Correct Answer
IgG - 33.
Name the correct antibody. Predominant in Ig secretions
Correct Answer
IgA - 34.
Name the correct antibod. Surface of B Lymphs
Correct Answer
IgD - 35.
Name the correct antibody. Mediates hypersensitivity reactions
Correct Answer
IgE - 36.
Antigenic binding portion of the antibody
- A.
Fab and Fc regions
- B.
2 heavy chains
- C.
2 light chains
- D.
Variable region
- E.
Constant region
Correct Answer
D. Variable region -
- 37.
Markers that distinguish Ig classes, sites can bind and activate complement
- A.
Variable region
- B.
Heavy chain
- C.
Hinge
- D.
Fc region
- E.
Fab region
Correct Answer
D. Fc regionExplanation
also has Fc receptorRate this question:
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- 38.
The antibody molecule is composed of two identical light chains and two identical heavy chains linked by disulfide bonds
- A.
True
- B.
False
Correct Answer
A. True -
- 39.
Anamnestic response/ memory response occurs after
- A.
Trauma
- B.
Repeated exposure to the same antigen
- C.
Taking medication
- D.
None of the above
Correct Answer
B. Repeated exposure to the same antigen -
- 40.
Which of the following is not a phase of the primary antibody response
- A.
Lag phase
- B.
Plateau phase
- C.
Log phase
- D.
Decline phase
- E.
Competitive phase
Correct Answer
E. Competitive phase -
- 41.
The secondary (Anamnestic) response has the same 4 phases as the primary response and come with repeated exposure
- A.
True
- B.
False
Correct Answer
A. True -
- 42.
Booster shots are a combination of primary and secondary response
- A.
True
- B.
False
Correct Answer
A. True -
- 43.
This cell, under the stimulation of a Thelper cell, returns to the bone marrow to mature
- A.
Pro-b cell
- B.
Immature b cell
- C.
Mature b cell
- D.
Plasma cell
Correct Answer
B. Immature b cell -
- 44.
Double negative thymocytes (DN) cells show no expression of CD4 or CD8 or TCR. These cells however go on to differentiate into CD4, CD8 and Natural Killer NK cells. Regarding this process, which of the following is not true.
- A.
CD8 cells must have partial recognition of MHC class I
- B.
Nk have expression of CD4 but not CD8
- C.
CD4 cells must have recognition of MHC class II
- D.
Must recognize self
Correct Answer
B. Nk have expression of CD4 but not CD8Explanation
NK cells show no expression of CD4 or CD8Rate this question:
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- 45.
Humoral immunity describes fluids that defend the body from microbial attack
- A.
True
- B.
False
Correct Answer
A. True -
- 46.
Antibody recognize and bind microbial epitopes
- A.
Agglutination
- B.
Opsonization
- C.
Neutralization
- D.
Complement activation
Correct Answer
A. Agglutination -
- 47.
Prevent microbial attachment to host
- A.
Agglutination
- B.
Opsonization
- C.
Neutralization
- D.
Complement activation
Correct Answer
C. Neutralization -
- 48.
Promotion of phagocytosis
- A.
Agglutination
- B.
Neutralization
- C.
Opsonization
- D.
Complement activation
Correct Answer
C. Opsonization -
- 49.
Activates cascade
- A.
Agglutination
- B.
Neutralization
- C.
Opsonization
- D.
Complement activation
Correct Answer
D. Complement activation -
- 50.
Which of the following would not be considered active humoral immunity
- A.
Natural exposure to pathogen
- B.
Given serum or plasma with high concentration of preformed antibody
- C.
Vaccination
- D.
Host makes antibodies
Correct Answer
B. Given serum or plasma with high concentration of preformed antibodyExplanation
when the antibodies are acquired from an outside source it provides passive immunity which is immediate but temporaryRate this question:
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Oct 18, 2018Quiz Edited by
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Sep 27, 2010Quiz Created by
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