Crystal Associated Arthropathies (Msq Drill 153)

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1. Under polarized microscopy gout crystals will look:
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2. Gout is basically hyperuricemia. How can hyperuricemia come about?
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3. Uric acid levels confirm a diagnosis of gout. True or false?

Explanation

A patient may have asymptomatic hyperuricemia that does not need to be treated.

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4. Which of the following are other drugs and toxins that can lead to UNDEREXCRETION of uric acid therefore hyperuricemia?
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5. After monopause, does the incidence of gout in women increase?
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6. Which stage of gout is characterized by tophaceous nodules?
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7. In females the same adult levels are reached at:
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8. The vast majority of patients with hyperuricemia do hot have symptoms. True or false?

Explanation

You do not have to treat asymptomatic pts with hyperuricemia.

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9. Is gout usually monoarticular or polyarticular?
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10. Does the gouty arthritis usually subside on it own?
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11. So, urate crystals will be present in synovial fluid?
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12. If you have multiple intermittent attacks of acute gout, you can eventually develop tophi anywhere over the body. True or false?
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13. Because allopurinol can make gout worse, it should only be taken when the acute episode is over, rather acute treatment should be initiated with "other" drugs. True or false?
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14. Is there a strong familial link to gout?
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15. In other words patients who have had a transplant and are taking cyclosporine will have rapid development of tophi. true or false?
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16. So psuedogout is:

Explanation

other causes for calcium pyrophosphate dihydrate crystals are asymptomatic chondroclacinosis and chronic arthropathy.

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17. So, basically you should use allopurino, probenecid and uloric to treat chornic gout after stabilization by acute meds. True or false?
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18. Psuedogout is caused by calcium pyrophosphate dihydrate crystals. True or false?
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19. Initial attack of gout in 75% of patients is in the:
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20. Does the joint fluid show an inflammatory process in patients with gout?

Explanation

poly morpho nuclear cells are granulocytes.

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21. 95% of the time does gout attack one joint or many joints?
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22. Gicing a patient aspirin can lead to?
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23. Gout is mostly a disease of:
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24. Which epideiological group NEVER suffers from gout?

Explanation

Estrogen appears to be protective of developing gout.

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25. In the asymptomatic stage of gout, does the patient have hyperuricemia?
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26. Can you have gouty arthritis and yet have NO hyperuricemia?

Explanation

You never check for uric acid level to see if a patient has gout. The uric acid has moved out of the serum into the joint.

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27. Alloupurinol is used in the treatment of gout. Can allopurinol actually makes gout worse?
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28. Other NSAIDS work just as well as indomethacin in alleviating the symptoms of gout. True or false?
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29. If you treat chronic gout appropriately can the tophi go away?
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30. Diagnosis of of gout is confirmed by:
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31. ETOH leads to which process that leads to hyperuricemia?
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32. The peak incidence of gout is in which decade of life?
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33. The following crystals can be found in synovial fluid. Which type is associated with acute and tophaceous gout and can be seen in asymptomatic hyperuricemia or intercritical gout?
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34. Indomethacin is an NSAID that has been used extensively in the treatment of gout. Its use is limited now due to its propensity to be:
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35. Which of the following are used in the acute treatment of gout?

Explanation

allopurinol is used to treat chronic gout.

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36. What type of drug is probenecid?
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37. What will the crystals look like if you do an arthrocentesis in a patient with psuedogout?
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38. Which stage of gout is characterized by intermittent attacks?
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39. In males adult levels of urate are reached at what age?
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40. What joint in the body is NEVER affected by acute gouty arthritis?
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41. Patients with gouty arthritis will often complain of AN ABRUPT ONSET of pain that began:
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42. Which of the following lead to hyperuricemia as a result of overproduction?

Explanation

low dose aspirin leads to undersecretion of uric acid.

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43. What is the upper limit for normal serum uric acid levels?
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44. Basically uric acid is the end product of degradation of purine compunds. If you lack the following enzymes that are responsible for the oxidation of uric acid you can develop hyperuricemia?

Explanation

xanthine oxidase is involved inthe formation of uric acid and not the break down.

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45. Which of the following are used to treat chronic gout?
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46. What joint is usually initially affected by pseudogout?
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47. What is the leukocyte count between in patients with Gout?
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48. The following are provocative facotrs of acute attacks of gout. Which factor is the reason why the first MTP is usually the first joint attacked by gout?
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49. The following are all causes of early onset gout. Which one is the only one that is associated with premonopausal women developing gout?
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50. DanPatients who have a had a transplant and are taking _____ have a very high risk of developing gout.
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51. These patients who have had a transplant and are taking cyclosporine will still have an episode of asymptomatic hyperuricemia, the only difference is that this episode will be shorter than average or will last longer than average?
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52. Which of the following conditions are associated with psuedogout?
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53. Processes that lead to increased breakdown of cellular components results in increased production ofuric acid. Which of the following can lead to hyperuricemia die to increased production?

Explanation

diuretics lead to hyperuricemia due to undersecretion as they compete with uric acid crystals at the distal tubules.

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Under polarized microscopy gout crystals will look:
Gout is basically hyperuricemia. How can hyperuricemia come about?
Uric acid levels confirm a diagnosis of gout. True or false?
Which of the following are other drugs and toxins that can lead to...
After monopause, does the incidence of gout in women increase?
Which stage of gout is characterized by tophaceous nodules?
In females the same adult levels are reached at:
The vast majority of patients with hyperuricemia do hot have symptoms....
Is gout usually monoarticular or polyarticular?
Does the gouty arthritis usually subside on it own?
So, urate crystals will be present in synovial fluid?
If you have multiple intermittent attacks of acute gout, you can...
Because allopurinol can make gout worse, it should only be taken when...
Is there a strong familial link to gout?
In other words patients who have had a transplant and are taking...
So psuedogout is:
So, basically you should use allopurino, probenecid and uloric to...
Psuedogout is caused by calcium pyrophosphate dihydrate crystals. True...
Initial attack of gout in 75% of patients is in the:
Does the joint fluid show an inflammatory process in patients...
95% of the time does gout attack one joint or many joints?
Gicing a patient aspirin can lead to?
Gout is mostly a disease of:
Which epideiological group NEVER suffers from gout?
In the asymptomatic stage of gout, does the patient have...
Can you have gouty arthritis and yet have NO hyperuricemia?
Alloupurinol is used in the treatment of gout. Can allopurinol...
Other NSAIDS work just as well as indomethacin in alleviating the...
If you treat chronic gout appropriately can the tophi go away?
Diagnosis of of gout is confirmed by:
ETOH leads to which process that leads to hyperuricemia?
The peak incidence of gout is in which decade of life?
The following crystals can be found in synovial fluid. Which type is...
Indomethacin is an NSAID that has been used extensively in the...
Which of the following are used in the acute treatment of gout?
What type of drug is probenecid?
What will the crystals look like if you do an arthrocentesis in a...
Which stage of gout is characterized by intermittent attacks?
In males adult levels of urate are reached at what age?
What joint in the body is NEVER affected by acute gouty arthritis?
Patients with gouty arthritis will often complain of AN ABRUPT ONSET...
Which of the following lead to hyperuricemia as a result of...
What is the upper limit for normal serum uric acid levels?
Basically uric acid is the end product of degradation of purine...
Which of the following are used to treat chronic gout?
What joint is usually initially affected by pseudogout?
What is the leukocyte count between in patients with Gout?
The following are provocative facotrs of acute attacks of gout. Which...
The following are all causes of early onset gout. Which one is the...
DanPatients who have a had a transplant and are taking _____ have a...
These patients who have had a transplant and are taking cyclosporine...
Which of the following conditions are associated with psuedogout?
Processes that lead to increased breakdown of cellular components...
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