Define Following CYP450 And Pgp Substrates, Inhibitors, And Inducers Flashcards

Caffeine Substrate, CYP1A2 Clozapine Substrate, CYP1A2, CYP3A4 Olanzapine Substrate, CYP1A2 Theophylline Substrate, CYP1A2 Clomipramine Substrate, CYP1A2, CYP2C19, CYP3A4 imipramine Substrate, CYP1A2, CYP2C19, CYP3A4 amitriptyline Substrate, CYP1A2, CYP2C19, CYP3A4 R-Warfarin Substrate, CYP1A2 Delete this card Delete this card haloperidol Substrate, CYP1A2 Inhibitor, CYP2D6 Delete this card Delete this card fluvoxamine Substrate, CYP1A2 Inhibitor, CYP1A2, CYP2C9/10 phenytoin Substrate, CYP2C9, CYP2C19 Inducer, CYP3A4 S-warfarin Substrate, CYP2C9 clotrimazole inducer for pgp phenobarbital Inducer for pgp Trifluoperazine inhibitor for pgp Miscellaneous propanolol inhibitor for pgp Cardiac drug nicardipine Inhibitor for pgp Cardiac drug nifedipine Inhibitor for pgp Cardiac drug itraconazole Inhibitor for pgp Antibiotic ceftriaxone Inhibitor for pgp Antibiotic metoprolol Substrate, CYP2D6 diazepam Substrate, CYP2C19 desmethyldiazepam Substrate, CYP2C19 lansoprazole Substrate, CYP2C19 Inhibitor, CYP2C19 aldosterone substrate for pgp Steroid omeprazole Substrate, CYP2C19 Inhibitor, CYP2C19 dexamethasone substrate for pgp Steroid propafenone Substrate, CYP2D6 All TCAs Substrate, CYP2D6 codeine Substrate, CYP2D6 dextromethorphan Substrate, CYP2D6 tramadol Substrate, CYP2D6 atomoxetine Substrate, CYP2D6 hydrocortisone substrate for pgp steroids paroxetine Substrate, CYP2D6 Inhibitor, CYP2D6 progesterone substrate for pgp inhibitor for pgp Steroid loperamide substrate for pgp miscellaneous mitomycin substrate for pgp Chemotherapy agent midazolam Substrate, CYP3A4 Ca 2+ channel blockers Substrate, CYP3A4 simvastatin Substrate, CYP3A4 atorvostatin Substrate, CYP3A4 lovastatin Substrate, CYP3A4 cyclosporine Substrate, CYP3A4 tacrolimus Substrate, CYP3A4 ritonavir Substrate, CYP3A4 Inhibitor, CYP2D6, CYP3A4 estrogens Substrate, CYP3A4 pimozide Substrate, CYP3A4 carbamazepine Substrate, CYP3A4 Inducer, CYP3A4 paclitaxel substrate for pgp Chemotherapy agent doxorubicin substrate for pgp Chemotherapy agent indinavir Substrate, CYP3A4 Inhibitor, CYP3A4 saquinavir Substrate, CYP3A4 Inhibitor, CYP3A4 erythromycin Substrate, CYP3A4 Inhibitor, CYP3A4 daunorubicin substrate for pgp Chemotherapy agent quinine Substrate, CYP3A4 Inhibitor, CYP3A4 vinca alkaloids substrate for pgp Chemotherapy agent dactinomycin substrate for pgp Chemotherapy agent digoxin Substrate for pgp Cardiac fexofenadine Substrate for pgp Antihistamine cimetidine Inhibitor, CYP1A2, CYP2C19, CYP2D6 amiodarone Inhibitor, CYP1A2, CYP2C9/10, CYP2D6 disulfiram Inhibitor, CYP1A2, CYP2C9/10, CYP3A4 ciprofloxacin Inhibitor, CYP1A2 levofloxacin Inhibitor, CYP1A2 enoxacin Inhibitor, CYP1A2 norfloxacin Inhibitor, CYP1A2 zafirlukast Inhibitor, CYP2C9/10 topiramate Inhibitor, CYP2C19 fluoxetine Inhibitor, CYP2D6 quinidine Inhibitor, CYP2D6 bupropion Inhibitor, CYP2D6 phenothiazines Inhibitor, CYP2D6 terbinafine Inhibitor, CYP2D6 diltiazem Inhibitor, CYP3A4 clarithromycin Inhibitor, CYP3A4 grapefruit juice Inhibitor, CYP3A4 nefazodone Inhibitor, CYP3A4 nelfinavir Inhibitor, CYP3A4 ketoconazole Inhibitor, CYP3A4 itraconazole Inhibitor, CYP3A4 verapamil Inhibitor, CYP3A4 tobacco Inducer, CYP1A2 rifampin Inducer, CYP2C9/10, CYP3A4 barbiturates Inducer, CYP2C9/10, CYP3A4 St. John's Wort Inducer, CYP3A4