USMLE Step 1 - Gross Anatomy and Embryology
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5 Sample Questions

DG101 - A 45-year-old man undergoes thyroidectomy for papillary thyroid carcinoma. Postoperatively, he experiences hoarseness and difficulty projecting his voice, though he can still speak. Laryngoscopy reveals paralysis of the vocal cord in a paramedian position. Which nerve was most likely injured during the surgery?

  • A. Recurrent laryngeal nerve*
  • B. External branch of the superior laryngeal nerve
  • C. Internal branch of the superior laryngeal nerve
  • D. Glossopharyngeal nerve
  • E. Hypoglossal nerve

DG102 - A newborn infant presents with cyanosis that worsens with feeding. Physical examination reveals a single second heart sound and a harsh systolic ejection murmur at the left upper sternal border. Echocardiography shows a large ventricular septal defect, an overriding aorta, right ventricular hypertrophy, and obstruction of the right ventricular outflow tract. Which embryological structure failed to develop normally?

  • A. Endocardial cushions
  • B. Neural crest cells*
  • C. Septum primum
  • D. Septum secundum
  • E. Sinus venosus

DG103 - A 28-year-old woman delivers a baby at 38 weeks gestation. The infant has difficulty breathing and appears to have a scaphoid (sunken) abdomen. Chest X-ray reveals loops of bowel in the left thoracic cavity with displacement of the heart to the right. Which structure failed to close properly during embryonic development?

  • A. Pleuroperitoneal membrane*
  • B. Foramen ovale
  • C. Ductus arteriosus
  • D. Pleuropericardial fold
  • E. Transverse septum

DG104 - A 65-year-old man with a history of atrial fibrillation presents with sudden onset of severe abdominal pain out of proportion to physical examination findings. He also reports bloody diarrhea. Laboratory studies show elevated lactate and leukocytosis. CT angiography reveals occlusion of a major mesenteric vessel. Which artery is most likely occluded?

  • A. Superior mesenteric artery*
  • B. Celiac trunk
  • C. Inferior mesenteric artery
  • D. Middle colic artery
  • E. Right gastric artery

DG105 - A 5-year-old boy is brought to the emergency department after falling from a tree and landing on an outstretched hand. Physical examination reveals a dinner fork deformity of the wrist. Radiographs confirm a fracture. Which nerve is most at risk for injury with this type of fracture?

  • A. Median nerve*
  • B. Ulnar nerve
  • C. Radial nerve
  • D. Axillary nerve
  • E. Musculocutaneous nerve