This quiz is designed to help test your knowledge and understanding of the key concepts of the TCA cycle (also known as the Krebs or Citric Acid cycle) and its regulation.

Each of our quizzes contains randomised question, so each attempt will be different! After you submit the answers for each question, hints and feedback are given to explain where you might have gone wrong or why you were right. Take the quiz now and see how much of an expert you are!

(For calculations you can assume that approximately 3.0 ATP are produced per NADH and 2.0 ATP per FADH2)

5 Sample Questions

What enzyme catalyses the only reaction in the TCA cycle that generates a carbon-carbon bond?
 

  • A. Aldolase
  • B. Citrate synthase
  • C. Succinyl-CoA synthase
  • D. Succinate dehydrogenase

What dehydrogenase enzyme In the TCA cycle does not have NAD+ as its coenzyme?

  • A. Malate dehydrogenase
  • B. Isocitrate dehydrogenase
  • C. Succinate dehydrogenase
  • D. α-Ketoglutarate dehydrogenase

The net products of one turn of the TCA cycle are:

  • A. 1 FADH2, 3 NADH, 1 GTP (ATP)
  • B. 2 FADH2, 6 NADH, 2 GTP (ATP)
  • C. 2 NADH, 2 ATP, 2 pyruvate
  • D. 3 NADH, CO2, 1 oxaloacetate

What enzyme of the TCA cycle uses GDP as a phosphate acceptor?

  • A. Citrate synthase
  • B. ATP synthase
  • C. Succinyl-CoA synthetase
  • D. Succinate dehydrogenase

All the enzymes of the TCA cycle are located in the cytoplasm except succinate dehydrogenase which is bound to the inner mitochondrial membrane. 

  • A. True
  • B. False

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