Diagnosis And Management Of Viral Hepatitis! Trivia Questions Quiz

18 Questions

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Diagnosis And Management Of Viral Hepatitis! Trivia Questions Quiz

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Questions and Answers
  • 1. 
    A 38-year-old woman screened for hepatitis presents the following serological status: HBsAg                   negative HBcAg IgG           positive HBsAg IgG            negative What is the most likely explanation for these results?
    • A. 

      Vaccination

    • B. 

      Resolved acute infection

    • C. 

      Chronic infection with undetectable HBsAg

    • D. 

      This is impossible

  • 2. 
    A 27-year-old female sex worker presents to a free clinic complaining of tea-colored urine and clay-colored stools. Patient history reveals a recent trip to Mexico and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. She admits to alcohol and injection drug abuse. Physical examination reveals epigastric discomfort and yellow-tinged sclerae. Blood work shows the following: Three years later, a new panel is performed on the same patient, with the following results: What is the status of this patient?  
    • A. 

      Acute HBV

    • B. 

      Chronic HBV

    • C. 

      Chronic, minimally replicating HBV

    • D. 

      Chronic, HBeAg-negative mutant HBV

  • 3. 
    How likely is it for this person to transmit the infection?
    • A. 

      Unlikely

    • B. 

      Likely

    • C. 

      Highly likely

  • 4. 
    A 27-year-old female sex worker presents to a free clinic complaining of tea-colored urine and clay-colored stools. Patient history reveals a recent trip to Mexico and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. She admits to alcohol and injection drug abuse. Physical examination reveals epigastric discomfort and yellow-tinged sclerae. Blood work shows the following: Three years later, a new panel is performed on the same patient, with the following results:   What is the status of this patient?
    • A. 

      Acute HBV

    • B. 

      Chronic HBV

    • C. 

      Chronic, minimally replicating HBV

    • D. 

      Chronic, HBeAg-negative mutant HBV

  • 5. 
    A 27-year-old female sex worker presents to a free clinic complaining of tea-colored urine and clay-colored stools. Patient history reveals a recent trip to Mexico and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. She admits to alcohol and injection drug abuse. Physical examination reveals epigastric discomfort and yellow-tinged sclerae. Blood work shows the following: Three years later, a new panel is performed on the same patient, with the following results: What is the status of this patient?
    • A. 

      Acute HBV

    • B. 

      Chronic HBV

    • C. 

      HBV-HDV co-infection

    • D. 

      HBV-HDV super-infection

  • 6. 
    A 25-year-old pregnant woman (2nd trimester) presents with tea-colored urine and clay-colored stools. Patient history reveals a recent trip to India and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. Physical examination reveals yellow-tinged sclerae. Blood work shows the following: One month later, a new panel is performed on the same patient, with the following results: What is the most likely cause of this patient’s hepatitis?
    • A. 

      HAV

    • B. 

      HBV

    • C. 

      HCV

    • D. 

      HDV

    • E. 

      HEV

  • 7. 
    What is the case fatality rate in this population of patient?
    • A. 

      0-10%

    • B. 

      10-20%

    • C. 

      20-30%

    • D. 

      30-40%

    • E. 

      40-50%

  • 8. 
    A 31-year-old male sex worker presents to a free clinic complaining of tea-colored urine and clay-colored stools. Patient history reveals a recent trip to Mexico and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. He admits to alcohol and injection drug abuse. Physical examination reveals epigastric discomfort and yellow-tinged sclerae. Blood work shows the following: What is the status of this patient?
    • A. 

      Acute HBV

    • B. 

      Chronic HBV

    • C. 

      Acute HCV

    • D. 

      Chronic HCV

    • E. 

      Acute HBV/Chronic HCV

    • F. 

      Chronic HBV/Acute HCV

  • 9. 
    What would be the most likely serology profile of a person vaccinated for both HAV and HBV?
    • A. 

      I

    • B. 

      II

    • C. 

      III

    • D. 

      IV

    • E. 

      V

    • F. 

      VI

    • G. 

      VII

    • H. 

      VIII

  • 10. 
    A 27-year-old female sex worker presents to a free clinic complaining of tea-colored urine and clay-colored stools. Patient history reveals a recent trip to Mexico and non-specific systemic symptoms such as fatigue, nausea, and low-grade fever. She admits to alcohol and injection drug abuse. Physical examination reveals epigastric discomfort and yellow-tinged sclerae. Blood work shows the following: Three years later, a new panel is performed on the same patient, with the following results: What is the status of this patient (choose the best answer)?  
    • A. 

      Resolved HBV infection

    • B. 

      Resolved HDV infection

    • C. 

      Resolved HBV-HDV co-infection

    • D. 

      Resolved HBV-HDV super-infection

  • 11. 
    What important consideration must be made when treating an HIV-HBV co-infected individual with antivirals?
    • A. 

      Need to wait until CD4 count drops to less than 200/mL

    • B. 

      Care must be taken to choose a nucleoside analog that has a low probability of inducing resistance in HBV

    • C. 

      IFN-a should be avoided

    • D. 

      Care must be taken to choose a nucleoside analog that has a low probability of inducing resistance in HIV

  • 12. 
    What conclusion(s) should be drawn from the following lab results? Three years later, a new panel is performed on the same patient, with the following results:
    • A. 

      Resolved HBV infection

    • B. 

      Current HDV infection

    • C. 

      Resolved HBV-HDV co-infection

    • D. 

      Resolved HBV-HDV super-infection

  • 13. 
    A patient with the following lab results undergoes treatment with peg-IFN-and ribavirin: What is the most likely presentation of this patient?
    • A. 

      Icteric

    • B. 

      Asymptomatic

  • 14. 
    What mechanism(s) contributed to the establishment of chronic disease?
    • A. 

      Disruption of Jak/STAT-mediated IFN signaling

    • B. 

      Induction of Treg-mediated immune tolerance

    • C. 

      Disruption of RIG-1- and TLR3-mediated viral recognition

    • D. 

      Capacity of the virus to cause little cytopathic effects

    • E. 

      All of the Above

  • 15. 
    Which molecule expression is likely to be increased as a result of peg-IFN-a treatment?
    • A. 

      PRB

    • B. 

      IFN-y

    • C. 

      Lactoferrin

    • D. 

      Cathepsin H

    • E. 

      Pkr

  • 16. 
    Which HCV genotype and viral replication status is hardest to treat?
    • A. 

      Genotype 1/RNA low

    • B. 

      Genotype 1/RNA high

    • C. 

      Genotype 2

    • D. 

      Genotype 3

  • 17. 
    Which mechanisms are involved in the development of HCC?
    • A. 

      Chronic inflammation

    • B. 

      Oxygen radical production by immune cells

    • C. 

      P53-mediated apoptosis

    • D. 

      Oncogene activation by viral transactivator

    • E. 

      ADCC

    • F. 

      All of the Above

  • 18. 
    Which HBV components are involved in the induction of tolerance and the establishment of chronic disease? Check ALL that apply
    • A. 

      HBs

    • B. 

      HBc

    • C. 

      HBe

    • D. 

      HBx

    • E. 

      RT