Translation Sample Questions

10 Questions

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Translation Quizzes & Trivia

Questions and Answers
  • 1. 
    Which statement about the “genetic code” is most accurate?
    • A. 

      Information is stored as sets of dinucleotide repeats called codons

    • B. 

      The code is degenerate (i.e., more than one codon may exist for a single amino acid)

    • C. 

      Information is stored as sets of trinucleotide repeats called codons

    • D. 

      There are 64 codons, all of which code for amino acids

    • E. 

      The sequence of codons that make up a gene exhibits an exact linear correspondence to the sequence of amino acids in the translated protein

  • 2. 
    • A. 

      -CCA-CCT-AGG-TTC-AGG-

    • B. 

      -GCC-CCT-AGG-TTC-AGG-

    • C. 

      -CCA-CCC-TAG-GTT-CAG-

    • D. 

      -CCC-CTA-GGT-TCA-GG- -

    • E. 

      -CCC-CCT-AGG-AGG- - -

  • 3. 
    Studies of the genetic code in bacteria have revealed that
    • A. 

      Messenger RNA (mRNA) molecules specify only one polypeptide chain

    • B. 

      Many triplets can be ”nonsense” triplets

    • C. 

      No signal exists to indicate the end of one codon and the beginning of another

    • D. 

      The nucleotide on the 5’ end of a triplet has the least specificity for an amino acid

    • E. 

      Gene sequence and encoded proteins are not colinear

  • 4. 
    1. What is the correct order of the following steps in protein synthesis?
      1. A peptide bond is formed
      2. The small ribosomal subunit is loaded with initiation factors, messenger RNA, and initiation aminoacyl-transfer RNA
      3. The intact ribosome slides forward three bases to read a new codon
      4. The primed small ribosomal subunit binds with the large ribosomal subunit
      5. Elongation factors deliver aminoacyl-tRNA to bind to the A site
    • A. 

      1, 2, 5, 4, 3

    • B. 

      2, 3, 4, 5, 1

    • C. 

      4, 5, 1, 2, 3

    • D. 

      3, 2, 4, 5, 1

    • E. 

      2, 4, 5, 1, 3

  • 5. 
    New proteins destined for secretion are synthesized in the
    • A. 

      Golgi apparatus

    • B. 

      Smooth endoplasmic reticulum

    • C. 

      Free polysomes

    • D. 

      Nucleus

    • E. 

      Rough endoplasmic reticulum

  • 6. 
    How many high-energy phosphate-bond equivalents are utilized in the process of activation of amino acids for protein synthesis?
    • A. 

      Zero

    • B. 

      One

    • C. 

      Two

    • D. 

      Three

    • E. 

      Four

  • 7. 
    The hydrolytic step leading to the release of a polypeptide chain from a ribosome is catalyzed by
    • A. 

      Stop codons

    • B. 

      Peptidyl transferase

    • C. 

      Release factors

    • D. 

      Dissociation of ribosomes

    • E. 

      UAA

  • 8. 
    Which of the following statements about ribosomes is true?
    • A. 

      They are an integral part of transcription

    • B. 

      They are found both free in the cytoplasm and bound to membranes

    • C. 

      They are bound together so tightly they cannot dissociate under physiologic conditions

    • D. 

      They are composed of RNA, DNA, and protein

    • E. 

      They are composed of three subunits of unequal size

  • 9. 
    Guanosine triphosphate (GTP) is required by which of the following steps in protein synthesis?
    • A. 

      Aminoacyl-tRNA synthetase activation of amino acids

    • B. 

      Attachment of ribosomes to endoplasmic reticulum

    • C. 

      Translocation of tRNA-nascent protein complex from A to P sites

    • D. 

      Attachment of mRNA to ribosomes

    • E. 

      Attachment of signal recognition protein to ribosomes

  • 10. 
    Erythromycin is the antibiotic of choice when treating respiratory tract infections in legionnaire’s disease, whooping cough, and Mycoplasma-based pneumonia because of its ability to inhibit protein synthesis in certain bacteria by
    • A. 

      Inhibiting translocation by binding to 50S ribosomal subunits

    • B. 

      Acting as an analogue of mRNA

    • C. 

      Causing premature chain termination

    • D. 

      Inhibiting initiation

    • E. 

      Mimicking mRNA binding