The Royal Disease

6 Questions | Total Attempts: 14

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The Royal Disease

The story of hemophilia


Questions and Answers
  • 1. 
    Queen Victoria was the Queen of England. She was born with a mutation in one of her genes. It did not show up in her because it was on one of her X chromosomes and her other X chromosome had a normal copy of the gene. What is a mutation?
    • A. 

      Something that you can catch

    • B. 

      Something that is caused by a bacteria or virus

    • C. 

      Something that is NOT able to be inherited

    • D. 

      A small change in a gene's DNA sequence

  • 2. 
    CHECK ALL THE CORRECT STATEMENTS.
    • A. 

      Most women have two X chromosomes

    • B. 

      Queen Victoria was a woman

    • C. 

      Queen Victoria only had one X chromosome

    • D. 

      Queen Victoria's mutation made her very ill

  • 3. 
    The couple's first 7 children were all healthy. Then Prince Leopold was born. When Leopold got a cut, he kept bleeding and bleeding. Doctors were called and he was diagnosed with a condition called "hemophilia". He had inherited it from his mother. Why was he ill?
    • A. 

      He was a boy and he did not have another X chromosome with the 'normal' gene on it.

    • B. 

      Because his mother married her cousin

    • C. 

      Because his father had the mutated gene too

    • D. 

      Because he kept getting hurt

  • 4. 
    "Leopold was a carrier of the hemophilia gene"
    • A. 

      True

    • B. 

      False

  • 5. 
    Sadly, Leopold died at age 30 after a fall that caused bleeding. He did have time to marry and have children though. His wife was NOT a carrier/did not have hemophilia. CHECK ALL THE CORRECT STATEMENTS: 
    • A. 

      His sons would not have had hemophilia

    • B. 

      His daughters would not have had hemophilia

    • C. 

      His wife may have caught hemophilia from Prince Leopold

    • D. 

      His daughters would all be carriers of the hemophilia gene