Pharm Lecture 2 Part1- Principles Of Pharmacology

60 Questions

Settings
Please wait...
Pharm Lecture 2 Part1- Principles Of Pharmacology

Part 1 of Review Quiz based on PPP for Pharmacology Lecture 2- Principles of Pharmacology


Questions and Answers
  • 1. 
    What are some factors affecting renal drug clearance?
  • 2. 
    What is the formula for creatinine clearance
  • 3. 
    Any chemical that affects the processes of a living organism
  • 4. 
    Tells a drug's chemical composition and molecular structure
    • A. 

      Non-proprietary name

    • B. 

      Generic name

    • C. 

      Proprietary name

    • D. 

      Chemical name

    • E. 

      Trade name

  • 5. 
    Name assigned by the US Adopted Names Council
    • A. 

      Chemical Name

    • B. 

      Generic Name

    • C. 

      Nickname

    • D. 

      Proprietary Name

    • E. 

      Trade Name

  • 6. 
    Drug name that has a registered trade mark, name registered by the drug's owner/ manufarturer
    • A. 

      Proprietary name

    • B. 

      Non proprietary name

    • C. 

      Common Name

    • D. 

      Chemical Name

    • E. 

      Generic Name

  • 7. 
    The study of science of how various drug forms influence pharmokinetics and pharmodynamic activity
    • A. 

      Pharmokinetics

    • B. 

      Pharmodynamic

    • C. 

      Pharmaceutics

    • D. 

      Pharmacognosy

    • E. 

      Pharmacotherapeutics

  • 8. 
    What the body does with the drug; Absorption-Distribution-Metabolism-Excretion
    • A. 

      Pharmaceutics

    • B. 

      Pharmacokinetics

    • C. 

      Pharmacodynamics

    • D. 

      Pharmacotherapeutics

    • E. 

      Pharmacognosy

  • 9. 
    Biochemical and physiological effect of the drug on the body tissue and microorganisms in or on the body
    • A. 

      Pharmaceutics

    • B. 

      Pharmacotherapeutics

    • C. 

      Pharmacokinetics

    • D. 

      Pharmacodynamics

    • E. 

      Pharmacognosy

  • 10. 
    What the drug does at the cellular level
  • 11. 
    Subdivision of Pharmacodynamics that describes what the drug does to the whole body
  • 12. 
    The use of drugs and the clinical indications for drugs to prevent and treat diseases
    • A. 

      Pharmaceutics

    • B. 

      Pharmacognosy

    • C. 

      Pharmacodynamics

    • D. 

      Pharmacokinetics

    • E. 

      Pharmacotherapeutics

  • 13. 
    The study of natural (plant and animal) drug sources, commonly known as herbals
    • A. 

      Pharmacognosy

    • B. 

      Pharmaceutics

    • C. 

      Pharmacodynamics

    • D. 

      Pharmacotherapeutics

    • E. 

      Pharmacokinetics

  • 14. 
    Movement of a drug from its site of administration into systemic circulation (blood)
    • A. 

      Absorption

    • B. 

      Administration

    • C. 

      Metabolism

    • D. 

      Distribution

    • E. 

      None of the above

  • 15. 
    Dosage form, route of administration, bioavalability of drug, and status of patient's circulation are all factors affecting
    • A. 

      Distribution

    • B. 

      Absorption

    • C. 

      Metabolism

    • D. 

      Excretion

    • E. 

      All of the above

  • 16. 
    Liquids, elixers and syrups have the fastest absorption rates, rivaled only by  enteric coated tablets
    • A. 

      True

    • B. 

      False

  • 17. 
    Delivery of the drug from the blood to the end target
    • A. 

      Absorption

    • B. 

      Excretion

    • C. 

      Distribution

    • D. 

      Metabolism

    • E. 

      None of the above

  • 18. 
    Drug moves from blood into
    • A. 

      Tissues

    • B. 

      Organs

    • C. 

      Body fluids

    • D. 

      All the above

  • 19. 
    Areas of more rapid distribution will result in higher drug concentrations
    • A. 

      True

    • B. 

      False

  • 20. 
    Drug characteristics, tissue properties, blood flow, protein binding properties, water soluble/fat soluble and blood brain barrier are factors affecting
    • A. 

      Metabolism

    • B. 

      Distribution

    • C. 

      Absorption

    • D. 

      All the above

    • E. 

      None of the above

  • 21. 
    Which is not a drug distribution pattern
    • A. 

      Drug stays within vascular system

    • B. 

      Drug distributes throughout body water

    • C. 

      Drug concentrates in specific tissues

    • D. 

      Drug distributes throughout body and tissue

    • E. 

      None of the above

  • 22. 
    • A. 

      Drug distributes throughout body water

    • B. 

      Drug concentrates in specific tissues

    • C. 

      Drug distributes throughout body and tissue

    • D. 

      Drug stays in vascular system

    • E. 

      None of the above

  • 23. 
    A drug of low molecular weight would most likely follow what distribution pattern
    • A. 

      Drug distributes throughout body water

    • B. 

      Drug concentrates in specific tissues

    • C. 

      Drug distributes throughout body and tissue

    • D. 

      Drug stays in vascular system

    • E. 

      None of the above

  • 24. 
    Chloroquine in liver, tetracycline in bone and teeth, iodine in thyroid glands describes which distribution patter
    • A. 

      Drug distributes throughout body water

    • B. 

      Drug concentrates in specific tissues

    • C. 

      Drug distributes throughout body and tissue

    • D. 

      Drug stays in vascular system

    • E. 

      None of the above

  • 25. 
    • A. 

      Drug distributes throughout body water

    • B. 

      Drug concentrates in specific tissues

    • C. 

      Drug distributes throughout body fluids and tissue

    • D. 

      Drug stays in vascular system

    • E. 

      None of the above

  • 26. 
    Which is not an area of rapid distribution
    • A. 

      Heart

    • B. 

      Liver

    • C. 

      Kidneys

    • D. 

      Brain

    • E. 

      Muscle

  • 27. 
    Which is not an area of slow distribution
    • A. 

      Muscle

    • B. 

      Fat

    • C. 

      Skin

    • D. 

      Heart

    • E. 

      None of the above

  • 28. 
    Extent of distribution is affected by membrane permeability and blood perfusion
    • A. 

      True

    • B. 

      False

  • 29. 
    Which does not affect Extent of distribution
    • A. 

      Lipid solubility

    • B. 

      Plasma pH

    • C. 

      Plasma protein binding

    • D. 

      Intracellular binding

    • E. 

      Blood perfusion

  • 30. 
    Protein binding capacity depends on the drug's ___________for protein binding
  • 31. 
    Only the unbound fraction of a drug has therapeutic action
    • A. 

      True

    • B. 

      False

  • 32. 
    Only the unbound fraction of a drug will be metabolized and/or excreted
    • A. 

      True

    • B. 

      False

  • 33. 
    When protein binding is reversible the bound drug acts as a reservoire which allows the active drug to continually be replaced, creating an __________________between the bound and unbound drug
  • 34. 
    Which variable does not affect the fraction of unbound drug
    • A. 

      Concentration of drug in body

    • B. 

      Amount of plasma protein

    • C. 

      Quality of plasma protein

    • D. 

      Concomitant administration of other protein binding drugs

    • E. 

      None of the above

  • 35. 
    If a drug X is 80% bound then __________ percent is biologically active
  • 36. 
    Which of the following plasma proteins are least likely to bind drugs
    • A. 

      Serum albumin

    • B. 

      Transferrin

    • C. 

      Lipoprotein

    • D. 

      Glycoprotein

    • E. 

      Globulins

  • 37. 
    Increase in quantity of plasma proteins may lead to excess free unbound drug
    • A. 

      True

    • B. 

      False

  • 38. 
    • A. 

      Toxicity

    • B. 

      Saturation of plasma proteins

    • C. 

      Decrease in the number of plasma proteins

    • D. 

      Increase in biologically active drug

  • 39. 
    Review of a patient's lab results indicates a decrease in plasma proteins,without having any further information what would be the best predicted diagnosis
    • A. 

      Malnutrition

    • B. 

      Renal disease

    • C. 

      Liver disease

    • D. 

      Catabolic state

    • E. 

      All of the above

  • 40. 
    When a drug displaces another binding site, this is best described as _______________ and can result in toxic levels of a drug.
    • A. 

      Displacement

    • B. 

      Drug/drug interaction

    • C. 

      Antagonism

    • D. 

      Synergism

    • E. 

      Apathy

  • 41. 
    Drug metabolism is also known as
  • 42. 
    Drug metabolism is the biological transformation of a drug into
    • A. 

      An inactive metabolite

    • B. 

      A more soluble compound

    • C. 

      A more potent metabolite

    • D. 

      All of the above

    • E. 

      None of the above

  • 43. 
    Drug metabolism occurs in the plasma,liver, kidneys, lungs and intestinal mucosa but the main site of drug metabolism is the
    • A. 

      Intestinal mucosa

    • B. 

      Plasma

    • C. 

      Liver

    • D. 

      Kidneys

    • E. 

      Lungs

  • 44. 
    Barbiturates and rifampin therapy decrease metabolism while erythromycin and ketoconazole drug therapy increase it
    • A. 

      True

    • B. 

      False

  • 45. 
    All of the following decrease metabolism except
    • A. 

      Cardiovascular dysfunction

    • B. 

      Renal insufficiency

    • C. 

      Rifampin therapy

    • D. 

      Starvation

    • E. 

      Obstructive jaundice

  • 46. 
    • A. 

      Increased

    • B. 

      Decreased

  • 47. 
    Accumulation of drugs and prolonged action of the effects of the drugs results from ______________ drug metabolism  
    • A. 

      Increased

    • B. 

      Decreased

  • 48. 
    Which is the most clinically important factor affecting drug metabolism
    • A. 

      Drug/food interactions

    • B. 

      Drug/drug interactions

    • C. 

      Cardiovascular dysfunctions

    • D. 

      Disease states

    • E. 

      Age and gender

  • 49. 
    Metabolism of a drug by the liver and its passage from the liver into the circulation is best described as______________effect
  • 50. 
    Which route does not bypass the first pass effect
    • A. 

      Buccal

    • B. 

      Transdermal

    • C. 

      Intramuscular

    • D. 

      Upper portion of rectum

    • E. 

      Inhalation

  • 51. 
    Which would not be a result of decreased first pass effect
    • A. 

      Accumulation of drugs

    • B. 

      Prolonged action of drug effects

    • C. 

      Diminished bioactive drug effect

    • D. 

      Higher potentially toxic bioactive drug effect

  • 52. 
    Elimination of drugs from the body occurs in several places but the main site is 
    • A. 

      Kidneys/ renal system

    • B. 

      Liver

    • C. 

      Sweat

    • D. 

      Hepatobiliary

    • E. 

      Lungs

  • 53. 
    Test of renal function; serum ____________________; or urine _________________clearance
  • 54. 
    While taking the history of an elderly new patient that has come to establish care you learn that they have diabetes, hypertension and a history or recurrent kidney infections, you go on to find out that they worked for a chemical waste removal company for 20 years before retirement, based upon this information you expect the patient will have impaired _____________function
  • 55. 
    Volume of serum or plasma that is cleared of creatinine  in one minute via urinary excretion; compares levels of creatinine in urine and blood; measures  renal function
  • 56. 
    A measure of the rate of drug elimination, the time it takes 1/2 of a drug to be removed from the body
  • 57. 
    A drug exerts its effect by making a cell do what it was not designed to do
    • A. 

      True

    • B. 

      False

  • 58. 
    Time needed for a drug to elicit a therapeutic response
    • A. 

      Onset

    • B. 

      Peak

    • C. 

      Duration

  • 59. 
    Time needed for a drug to reach its maximum therapeutic effect
    • A. 

      Onset

    • B. 

      Peak

    • C. 

      Duration

  • 60. 
    Length of time that drug concentration is sufficient to elicit a therapeutic response
    • A. 

      Onset

    • B. 

      Peak

    • C. 

      Duration