Pharmacology Exam Trivia Quiz 2
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If you wish to work at the Creighton Pharmacy all you need to show is that you passed the pharmacology exam and can easily meet the duties assigned to you. Do you think that you have what it takes to tackle the pharmacology exam trivia below? Take it and get to see just how attentive you have been in class.
- 1.This subdivision of the Peripheral Nervous System controls voluntary skeletal movement:
- A.
Efferent Division
- B.
Somatic System
- C.
Parasympathetic System
- D.
Sympathetic System
- 2.Where is acetylcholine used as a neurotransmitter?
- A.
Pre-ganglionic nerve synapses
- B.
In neuroeffector junctions in the Parasympathetic Nervous System
- C.
Neuroeffector junction of the sympathoadrenal gland in the SNS
- D.
In sweat glands at the sympathetic cholinergic junction
- E.
In the somatic nervous system at the neuromuscular junction
- 3.Epinephrine is a neurotransmitter released from the adrenal gland.
- A.
True
- B.
False
- 4.Where are nicotinic receptors located?
- A.
Effectors stimulated by norepinephrine
- B.
Ganglia of SNS & PSNS & neuromuscular junction of the Somatic NS
- C.
Sweat glands innervated by the SNS
- 5.When the sympathetic system is dominated, what will the effect be on the radial muscle of the eye?
- A.
Relaxation
- B.
Loss of control
- C.
Acceleration
- D.
Constriction
- 6.What is a way that the Parasympathetic & Sympathetic Nervous Systems "communicate"?
- A.
There is no communication between the two
- B.
They regulate each other's function. For example, when the Sympathetic NS is stimulated, acetylcholine release is decreased by the A2 receptor, leading to further "domination" of the SNS
- C.
They regulate each other's function. For example, when the Sympathetic NS is stimulated, norepinephrine release is decreased by the M5 receptor, leading to further "domination" of the Parasympathetic NS.
- 7.Smooth muscle in the skin is mediated by ____ stimulation & is thermoregulated.
- A.
A1
- B.
B1
- C.
A2
- D.
B2
- 8.The parasympathetic NS is termed the "fight or flight system"
- A.
True
- B.
False
- 9.The dominant parasympathetic/sympathetic tone controlling the bladder at rest is:
- A.
Parasympathetic
- B.
Sympathetic
- 10.Where does synthesis of acetylcholine occur?
- A.
Neuroeffector junction of the SNS
- B.
Storage vesicles in the nerve ending
- C.
Cytoplasm of the nerve ending
- 11.Pseudocholinesterase is selective only for ACh
- A.
True
- B.
False
- 12.What happens to the majority of ACh that is released into the synapse of the nerve?
- A.
It is taken back into the cell by a reuptake pump
- B.
It is broken down rapidly by acetylcholinesterase
- C.
It is taken up by the cholinoceptors on the postsynaptic cell & creates action potential
- D.
It goes back into the cell to regulate its own release
- 13.The final step in the production of norepinephrine occurs in the cytoplasm of the nerve terminal.
- A.
True
- B.
False
- 14.What is responsible for the breakdown of norepinephrine?
- A.
COMT
- B.
BuChE
- C.
Various esterases
- D.
MAO
- 15.Which part of the release of ACh does Botox inhibit?
- A.
It inhibits the docking protein that causes the vesicle to dock with the cell membrane and release the contents of the vesicle
- B.
It inhibits the reuptake of acetylcholine, causing it to stay in the synapse for a longer period of time and have a greater therapeutic effect
- C.
It causes the ACh to be released prematurely from the vesicle
- D.
It blocks the regulation of ACh once it is released into the neuroeffector junction, leading to uncontrollable release
- 16.Why is a small dose of acetylcholine produce minimal effects?
- A.
Cardiovascular compensory reflexes
- B.
The dose is small & rapidly destroyed
- C.
Acetylcholine doesn't produce many effects
- D.
There is prolonged parasympathetic effect
- E.
The sympathetic nerves are stimulated
- 17.If you are trying to read a paper that is within 4 inches of your face, how does your eye compensate?
- A.
The ciliary muscle contracts, leading to pupillary constriction
- B.
The suspensory ligament relaxes
- C.
The lens of the eye becomes more concave
- D.
The lens of the eye becomes more flat
- E.
The ciliary muscle relaxes, leading to suspensory ligament contraction
- 18.Direct acting cholinomimetics bind to & activate muscarinic or nicotinic receptors
- A.
True
- B.
False
- 19.What is a name for a drug that mimicks the action of acetylcholine?
- A.
Cholinomimetics
- B.
Cholinergic agonists
- C.
Parasympathomimetics
- D.
Anticholinergics
- E.
Muscarinic agonists
- 20.Which kind of nicotinic receptor is stimulated by the Somatic Nervous System?
- A.
Nm
- B.
Nn
- 21.Where are the M2 cholinoceptor subtype located?
- A.
CNS, SNS cells
- B.
CNS, lung
- C.
CNS
- D.
Heart, neurons, smooth muscle
- E.
Glands, smooth muscle, endothelium
- 22.Which muscarinic receptors are linked to the Gi (inhibitory) pathway?
- A.
M1
- B.
M2
- C.
M3
- D.
M4
- E.
M5
- 23.There are muscarinic receptors on blood vessels.
- A.
True
- B.
False
- 24.Without vagal stimulation, the heart rate is naturally faster.
- A.
True
- B.
False
- 25.How are cholinomimetics useful in the treatment of glaucoma?
- A.
The radial muscle is contracted, leading to an escape of aqueous humor through the posterior chamber.
- B.
It leads to contraction of the ciliary muscles, which relaxes the suspensory ligaments of they eye, leading to aqueous humor outflow through the canal of schlemm leading to the anterior chamber.
- C.
Relaxation of the ciliary muscle leads to contraction of the suspensory ligament which leads to decreased IOP
- D.
Cholinomimetics are dangerous to use for the treatment of glaucoma.
- 26.A large dose of acetylcholine (5mg) after being given atropine will lead to:
- A.
An increase in HR and a decrease in BP
- B.
An increase in HR & an increase in BP
- C.
No effect. Receptors are blocked
- D.
A decrease in HR & BP
- 27.Used to treat "dry mouth" in patients who were given radiation treatment for cancers of the head & neck.
- A.
Bethanechol
- B.
Pilocarpine
- C.
Methacholine
- D.
Carbachol
- E.
Cevimeline
- 28.Used as an agent to treat glaucoma & lower the IOP.
- A.
Bethanechol
- B.
Pilocarpine
- C.
Methacholine
- D.
Carbachol
- E.
Cevimeline
- 29.Used to treat ineffective esophageal motility.
- A.
Bethanechol
- B.
Pilocarpine
- C.
Methacholine
- D.
Carbachol
- E.
Cevimeline
- 30.Muscarinic antagonists are used in the treatment of glaucoma.
- A.
True
- B.
False
- 31.Nicotinic receptors need 1 alpha subunits to be functional.
- A.
True
- B.
False
- 32.Which is NOT a natural reward?
- A.
Food
- B.
Water
- C.
Urination
- D.
Nurturing
- E.
Love
- 33.COPD is a progressive disease but using tiotropium can reverse the progress.
- A.
True
- B.
False
- 34.In which of these systems is the dominating tone Sympathetic?
- A.
GI
- B.
Cardiac
- C.
Vasculature
- D.
Upper respiratory
- E.
Eyes
- 35.If a ganglionic blocker on the vasculature was given, what would be the result?
- A.
Increased vasoconstriction
- B.
Increased vasodilation
- C.
None, there is no innervation by the parasympathetic system to the vessels
- 36.Competitive neuromuscular blocking drugs show "transiet fasiculations" before flaccid paralysis.
- A.
True
- B.
False
- 37.If a ganglionic blocking drug's structure is similar to the structure of acetylcholine, what side effects may you see?
- A.
Block of the autonomic ganglia, block of cardiac receptors or histamine release
- B.
No effects.
- C.
Strong block of all receptors that acetylcholine binds to.
- 38.Botulinum toxins cleave proteins that are responsible for the fusion of the storage vesicle with the cell membrane.
- A.
True
- B.
False
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