Pharmacology Dr. Smith Questions

27 Questions

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Pharmacology Dr. Smith Questions

Exam 1 Dr. Smith's questions


Questions and Answers
  • 1. 
    What affects absorption? (Check all that apply)
    • A. 

      Food/Type of food/Full,Empty stomach

    • B. 

      Blood flow to area

    • C. 

      Dosage form of the drug (ie. immediate/extended release/patch)

    • D. 

      Physicochemical properties of the drug

    • E. 

      Protein binding

    • F. 

      Concentration of the drug

    • G. 

      Route of administration

    • H. 

      GI motility & pH (antacids like tums/NSAIDS/Prilosec)

  • 2. 
    Bioavailability is?
    • A. 

      Only unbound or free drug is available to interact with receptors and exert its full effect

    • B. 

      Proportion of the drug that reaches the systemic circulation after administration

    • C. 

      Proportion of the drug that reaches the systemic circulation before administration

    • D. 

      Process through which a drug establishes equilibrium

  • 3. 
    Drugs that are given IV are NOT 100% bioavailable
    • A. 

      True

    • B. 

      False

  • 4. 
    Protein Binding
    • A. 

      Permeability across tissue barriers

    • B. 

      After absorption into plasma and lymph, drugs may circulate throughout the body bound (albumin)

    • C. 

      Only unbound or free drug is available to interact with receptors and exert its effect

    • D. 

      Bound & unbound lie in equilibrium

    • E. 

      When drug is eliminated, bound drug can be released to become active or free drug

    • F. 

      Affected by nutrition status/renal function/levels of circulating protein

  • 5. 
    The condition in which the rate of drug administration & rate of drug elimination are equal is
    • A. 

      Steady state

    • B. 

      Half life

    • C. 

      Condition of metabolism

    • D. 

      Condition of distribution

  • 6. 
    Attainment of steady state can be assumed after 3-4 half lives
    • A. 

      True

    • B. 

      False

  • 7. 
    Loading doses may be given for drugs with short half lives when a therapeutic level is needed quickly
    • A. 

      True

    • B. 

      False

  • 8. 
    First Pass Metabolism
    • A. 

      Some drugs given orally are metabolized by the liver before given a chance to to into systemic circulation

    • B. 

      Oral bioavailability is poor

    • C. 

      Marked individual variations occur

    • D. 

      Primarily in the kidneys

  • 9. 
    1/4 of marketed meds are FDA approved in Pediatrics
    • A. 

      True

    • B. 

      False

  • 10. 
    Pediatrics (check all that apply)
    • A. 

      Pharmacokinetic/Pharmacodynamic/Safety & Efficacy data of drugs are hard to find

    • B. 

      Optimal dosing is hard to find due to differences in age, organ fxn, and disease state

    • C. 

      Many meds aren't in available doses

    • D. 

      Altering medications raise questions about bioavailability/stability/compatibility

    • E. 

      Have low fluid volume requirements and limited access to IV sites

    • F. 

      PO meds pose problem in many

  • 11. 
    Drug Thereapy Pain Management Neonates and young infants perceive pain more intensely
    • A. 

      True

    • B. 

      False

  • 12. 
    Medication Compliance issues in pediatrics (Check all that apply)
    • A. 

      Poor communication between provider and patient

    • B. 

      Insufficient prescribing information

    • C. 

      Lack of understand about illness severity and lack of interest

    • D. 

      Fear of side effects

    • E. 

      Failure of patient/parent to give meds

    • F. 

      Inconvenient dosage forms or schedules

    • G. 

      Unpalatability of meds

  • 13. 
    Age changes the body's abilities in a lot of ways (Check all that apply)
    • A. 

      Glomerular filtration is decreased (doses need to be reduced)

    • B. 

      # of receptors and affinity for receptors change

    • C. 

      Geriatrics are more sensitive to benzodiazepines

    • D. 

      Geriatrics have increased analgesic response

    • E. 

      Enhanced response to anticoagulants

    • F. 

      Decreased response to beta-agonists and beta-antagonists

  • 14. 
    Geriatrics have drug related issues such as: Polypharmacy- concomitant use of multiple meds or administration of more meds than are clinically indicated
    • A. 

      True

    • B. 

      False

  • 15. 
    What are some compliance issues in geriatric patients?
    • A. 

      Cost of meds

    • B. 

      Possible ADRs

    • C. 

      Inability to read labels

    • D. 

      Laziness

    • E. 

      Lack of understanding of information about the medication

  • 16. 
    What are the top 3 medications that can cause skin reactions?
    • A. 

      Amoxicillin

    • B. 

      Blood

    • C. 

      Sulfamethoxizil (TMP-SMZ)

    • D. 

      Erthythromycin

    • E. 

      Ampicillin

    • F. 

      Azythromax

  • 17. 
    You enter room 2 in the ED and have an adult patient telling you they were just bit by fire ants. Their tongue is swelling and hands are swelling. The first thing you do is assess the airway, breathing, circulation and adequacy of mentation. Then you administer an aqueous epinephrine (1:1000 dilution, 0.2-0.5mL) IM q5 min as necessary to control the symptoms and bp. Is this what you would do to manage anaphylaxis?
    • A. 

      True

    • B. 

      False

  • 18. 
    Medication therapy for anaphylaxis would contain the following: (Check all that apply)
    • A. 

      Diphenhydramine (Benadryl)

    • B. 

      Zantac

    • C. 

      If resistant to epi use Proventil (nebulized albuterol)

    • D. 

      Methyldopa

  • 19. 
    When is the MMR given?
    • A. 

      1-2 months of age

    • B. 

      12-15 months of age

    • C. 

      4-6 years of age

    • D. 

      19-23 months of age

  • 20. 
    When is the Zoster vaccine given?
    • A. 

      19-26 years

    • B. 

      27-49 years

    • C. 

      60-64 years

    • D. 

      > 65 years

  • 21. 
    An infant has an order for 26mcg of digoxin. The medication is available in a solution of 0.1 mg/mL. How many mL would be given for this dose?