Pharmacology Drug Metabolism
Drug Metabolism quiz.
- 1.What is the mechanism by which the body terminates the action of some drugs and also serves to activate prodrugs?
- A.
Bioavailability
- B.
Biotransformation
- C.
Enzyme induction
- D.
Enzyme inhibition
- E.
None of the above
- 2.What phase 1 reaction is mainly performed by the cytochrome P450 enzymes also called mixed-function enzymes?
- A.
Hydrolysis
- B.
Oxidation
- C.
Reduction
- 3.What drug's metabolism has phase 2 preceding phase 1?
- A.
Mitomycin C
- B.
Ketoconazole
- C.
Isoniazid
- D.
Tamoxifen
- E.
Morphine
- 4.What drug after phase 2 results in a more active metabolite?
- A.
Mitomycin C
- B.
Ketoconazole
- C.
Isoniazid
- D.
Ethanol
- E.
Morphine
- 5.What is resonsible for conjugating bilirubin in the liver and facilitating its excretion?
- A.
UDP-glucuronosyl transferase
- B.
N-acetyltransferase
- C.
Pseudocholinesterase
- D.
Vitamin K epoxide reductase
- E.
Alcohol dehydrogenase
- 6.What does lack of UDP-glucuronosyl transferase cause?
- A.
Bilirubin encephalopathy
- B.
Neonatal jaundice
- C.
Kernicterus
- D.
A and B
- E.
All of the above
- 7.What induces UDP-glucuronosyl tranferase?
- A.
Phototherapy
- B.
Barbiturate phenobarbital
- C.
N-acetylcysteine
- D.
A and B
- E.
All of the above
- 8.An inducer will cause what to happen?
- A.
Increase the amount of isozymes and increase metabolism
- B.
Decrease the amount of isozymes and increase metabolism
- C.
Increase the amount of isozymes and decrease metabolism
- D.
Decrease the amount of isozymes and decrease metabolism
- E.
None of the above
- 9.What drugs are metabolized to products that irreversibly inhibit the metabolizing?
- A.
CYP3A4 inhibitor
- B.
Slow acetylators
- C.
Suicide inhibitors
- D.
P-gp inhibitors
- E.
None of the above
- 10.What usually functions to expel drugs from the intestinal mucosa into the lumen?
- A.
Single nucleotide polymorphism
- B.
Slow acetylators
- C.
Smoking
- D.
P-glycoprotein
- E.
Grapefriut juice
- 11.Oxidation of ethanol, estrogens, benzodiazepines and salicylates in women is what compared to men?
- A.
Increased
- B.
Decreased
- C.
The same
- D.
Cannot be determined
- 12.Which of the following is known to inhibit the CYP3A4 metabolism and P-glycoprotein in the small intestine?
- A.
Single nucleotide polymorphism
- B.
Slow acetylators
- C.
Smoking
- D.
P-glycoprotein
- E.
Grapefriut juice
- 13.Which of the following is induces enzymes in the liver and lungs?
- A.
Single nucleotide polymorphism
- B.
Slow acetylators
- C.
Smoking
- D.
P-glycoprotein
- E.
Grapefriut juice
- 14.How can a women on hormonal contraceptives become pregnant?
- A.
If she also takes a CYP3A4 inducer
- B.
If she also takes a CYP3A4 inhibitor
- C.
She cannot get pregnant
- D.
Cannot predict
- 15.What enzyme will methanol and ethanol both compete for?
- A.
UDP-glucuronosyl transferase
- B.
N-acetyltransferase
- C.
Pseudocholinesterase
- D.
Vitamin K epoxide reductase
- E.
Alcohol dehydrogenase
- 16.What is the antidote for acetaminophen overdose to protect patients from hepatotoxicity and death?
- A.
Phototherapy
- B.
Barbiturate phenobarbital
- C.
N-acetylcysteine
- D.
A and B
- E.
All of the above
- 17.Which of the following will treat neonatal jaundice?
- A.
Phototherapy
- B.
Barbiturate phenobarbital
- C.
N-acetylcysteine
- D.
A and B
- E.
All of the above
- 18.Who may have prolonged or toxic reponses to normal doses of that drug?
- A.
Slow acetylators
- B.
Fast metabolizers
- C.
Ultra metabolizers
- D.
B and C
- E.
All of the above
- 19.Which of the following is an antiepileptic drug that induces CYP3A4 and is also metabolized by CYP3A4?
- A.
Ketoconazole
- B.
Tamoxifen
- C.
Carbamazepine
- D.
Mitomycin C
- E.
Losartan
- 20.Which of the followinf is an antifungal drug that binds to P450 enzymes causing competitive inhibition?
- A.
Ketoconazole
- B.
Tamoxifen
- C.
Carbamazepine
- D.
Mitomycin C
- E.
Losartan
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