Pharm9: Drug Metabolism

10 Questions | Total Attempts: 1312

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Metabolism Quizzes & Trivia

Questions based on handout and suggested reading for Pharm 9 lecture by GPK.


Questions and Answers
  • 1. 
    The presence of any of these functional groups EXCEPT which of the following will allow a drug to enter phase II biotransformation without first passing through phase I?
    • A. 

      Amino (-NH2)

    • B. 

      Ketone (C=O)

    • C. 

      Carboxyl (COOH)

    • D. 

      Alcohol (-OH)

  • 2. 
    • A. 

      To inactivate and detoxify drugs and other foreign compounds that may cause harm to the body

    • B. 

      To incorporate drugs into extracellular matrix structures

    • C. 

      To modify drugs in ways that will promote reabsorption from the kidneys

    • D. 

      To sequester drugs into peripheral lymph organs to be examined by dendritic cells

  • 3. 
    Drugs absorbed from the gut reach the liver via the hepatic portal system before entering:
    • A. 

      The gallbladder

    • B. 

      The systemic circulation

    • C. 

      The colon

    • D. 

      The thoracic duct

  • 4. 
    In contrast to drugs after phase I biotransformation, drugs after phase II have:
    • A. 

      More pharmacological activity and greater water solubility

    • B. 

      Less pharmacological activity and greater water solubility

    • C. 

      More pharmacological activity and lower water solubility

    • D. 

      Less pharmacological activity and lower water solubility

  • 5. 
    When a drug is present in therapeutic amounts, Phase I or II reactions proceed with___________, and when a drug is present at toxic concentrations, phase I or II reactions proceed with ________________.
    • A. 

      Zero-order kinetics; zero-order kinetics

    • B. 

      Zero-order kinetics; first-order kinetics

    • C. 

      First-order kinetics; second-order kinetics

    • D. 

      First-order kinetics; zero-order kinetics

  • 6. 
    Drug interactions are rarer for a drug that passes directly into phase II biotransformation than for one that requires phase I biotransformation.
    • A. 

      True

    • B. 

      False

  • 7. 
    If transcription of CYP is upregulated,
    • A. 

      More drug than usual must be given to reach therapeutic levels.

    • B. 

      Less drug should be given to avoid toxicity.

    • C. 

      Then CYP levels in the cytoplasm will be reduced.

    • D. 

      Drug interactions will be more likely

  • 8. 
    The overall rate of biotransformation is higher in neonates and infants than in adults.
    • A. 

      True

    • B. 

      False

  • 9. 
    In comparison with children and young adults, elderly adults tend to have a reduced capacity to metabolize drugs.
    • A. 

      True

    • B. 

      False

  • 10. 
    Phase II acetylation of a drug, and
    • A. 

      This usually causes inactivation, but results in decreased solubility

    • B. 

      This can cause crystallization in urine

    • C. 

      If that drug is given in a large dose, a patient should also drink plenty of water

    • D. 

      All of the above