Online GPAT Mock Test No.3 Developed By Dr. Anwar Shaikh

50 Questions | Total Attempts: 497

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Online GPAT Mock Test No.3 Developed By Dr. Anwar Shaikh

Questions of Med. Chem. Of this tests are prepared by Mr. Khan Majid Shabbir, Assit. Professor of Pharm. Chemistry J. D. Pawar College of Pharmacy, Manur Kalwan. NashikTotal Questions:50, Marks: 200, Each correct Answer: 4 marks, Each Wrong Answer: -1 Mark


Questions and Answers
  • 1. 
    Which feature of acetylcholine interacts with the binding site of cholinergic receptors by hydrogen bonding?
    • A. 

      The acyl methyl group

    • B. 

      The ester

    • C. 

      The quaternary nitrogen

    • D. 

      All three N-methyl groups

  • 2. 
    Following structure (carbachol) is a cholinergic agonist.What is the purpose of the amino group in red?
    • A. 

      It acts as a metabolically susceptible group.

    • B. 

      It interacts with a hydrophilic pocket in the binding site.

    • C. 

      It acts as a steric shield to protect the ester group.

    • D. 

      It protects the neighbouring ester group by means of an electronic effect.

  • 3. 
    What feature of the D-Tubacurarine structure is crucial to its activity?
    • A. 

      The phenol ring

    • B. 

      The isoquinoline rings

    • C. 

      The isoquinoline rings

    • D. 

      The two positively charged nitrogen atoms

  • 4. 
    Atracurium is used intravenously as a neuromuscular blocker.The molecule undergoes a chemical degradation at slightly alkaline pH. What is the name of this reaction?
    • A. 

      Hofmann rearrangement

    • B. 

      Hofmann elimination

    • C. 

      Cope rearrangement

    • D. 

      McLafferty rearrangement

  • 5. 
    Commercially what was the use of Parathione ?
    • A. 

      A medicine in the treatment of glaucoma

    • B. 

      An antidote to anticholinesterase poisoning

    • C. 

      An insecticide

    • D. 

      A medicine in the treatment of Alzheimer's disease

  • 6. 
    Preserve foods by using salts and sugars works by
    • A. 

      Raising pH.

    • B. 

      Depleting nutrients.

    • C. 

      Lowering osmotic pressure

    • D. 

      Creating a hypertonic environment.

  • 7. 
    Which of the following methods will not sterilize?
    • A. 

      500 mg/L ethylene oxide at 501/4 C for 4 hours

    • B. 

      Aqueous glutaraldehyde for 10 hours

    • C. 

      Dry heat at 1711/4 C for 1 to 2 hours

    • D. 

      1001/4 C boiling water for 30 minutes

  • 8. 
    Which of the following does not kill endospores? 
    • A. 

      Autoclave

    • B. 

      Incineration

    • C. 

      Pasteurization

    • D. 

      Ot air sterilization

  • 9. 
    Which of the following is best to sterilize heat labile solutions?
    • A. 

      Dry heat

    • B. 

      Membrane filtration

    • C. 

      Autoclave

    • D. 

      Pasteurization

  • 10. 
    Which of the following is bactericidal?
    • A. 

      Membrane filtration

    • B. 

      Ionizing radiation

    • C. 

      Freeze-drying

    • D. 

      Deep freezing

  • 11. 
    Is Known as father of medicine?
    • A. 

      Aristotle

    • B. 

      Dioscorides

    • C. 

      Hippocrates

    • D. 

      Galen

  • 12. 
    Drug is not under the class of organized drug :
    • A. 

      Leaves

    • B. 

      Flowers

    • C. 

      Fruits

    • D. 

      Gums

  • 13. 
    Drug is not under the seed class :
    • A. 

      Nux vomica

    • B. 

      Digitalis

    • C. 

      Stropanthus

    • D. 

      Ispgol

  • 14. 
    Drug which does not belong to leaves class :
    • A. 

      Senna

    • B. 

      Digitalis

    • C. 

      Eucalyptus

    • D. 

      Turmeric

  • 15. 
    ______ is not used as expectorant. 
    • A. 

      Ipecacuanha

    • B. 

      Vasaka

    • C. 

      Liquorice

    • D. 

      Atropine

  • 16. 
    Which of the following is a natural chemical messenger for the adrenergic receptor?
    • A. 

      Acetylcholine

    • B. 

      Dopamine

    • C. 

      Serotonin

    • D. 

      Noradrenaline

  • 17. 
    What is the predominant adrenoceptor in heart muscle?
    • A. 

      α1-adrenoceptor

    • B. 

      α2-adrenoceptor

    • C. 

      β1-adrenoceptor

    • D. 

      β2-adrenoceptor

  • 18. 
    What is the main clinical use for agonists of the β2-adrenoceptor?
    • A. 

      Treatment of angina

    • B. 

      Treatment of hypertension

    • C. 

      Treatment of asthma

    • D. 

      Treatment of pain

  • 19. 
    What is the predominant β-adrenoceptor in bronchial smooth muscle?
    • A. 

      β1-adrenoceptor

    • B. 

      β2-adrenoceptor

    • C. 

      β3-adrenoceptor

    • D. 

      β4-adrenoceptor

  • 20. 
    To which class of compounds do adrenaline, noradrenaline and dopamine belong?
    • A. 

      Phenethylamines

    • B. 

      Diphenolethylamines

    • C. 

      Catecholamines

    • D. 

      Adrenergics

  • 21. 
    Identify the tactic which is used to obtain β-adrenoceptor selectivity for adrenergic agonists. 
    • A. 

      Introduction of a naphthalene ring

    • B. 

      Introduction of a bulky N-alkyl substituent

    • C. 

      Removal of one of the catechol OH groups

    • D. 

      Addition of an α-methyl group (alpha to the carbon bearing the amine)

  • 22. 
    What term is used to indicate the ability of a cancer to invade other parts of the body and to produce secondary tumours?
    • A. 

      Carcinogenesis

    • B. 

      Apoptosis

    • C. 

      Metastasis

    • D. 

      Mutagenesis

  • 23. 
    Which of the following heterocyclic rings forms part of the tropane skeleton?
    • A. 

      Imidazolidine

    • B. 

      Pyrazoline

    • C. 

      Piperazine

    • D. 

      Pyrrolidine

  • 24. 
    Carbachol is more stable than acetylcholine to hydrolysis. Which of the following statements is not true?
    • A. 

      The blue coloured methyl group of acetylcholine is susceptible to oxidation by cytochrome p450 enzymes.

    • B. 

      The blue coloured nitrogen of carbachol stabilises the neighbouring carbonyl group.

    • C. 

      Carbachol contains a urethane group while acetylcholine contains an ester group.

    • D. 

      The blue coloured NH2 group of carbachol is a bio-isostere for the blue coloured CH3 group of acetylcholine.

  • 25. 
    In Parkinson's disease, there is a lack of the neurotransmitter dopamine in the brain. Adding dopamine itself is not very effective for a variety of reasons. Which of the following statements is not a valid explanation?
    • A. 

      Dopamine is too polar to cross the blood-brain barrier.

    • B. 

      Dopamine is chemically unstable.

    • C. 

      Dopamine is metabolised to inactive metabolites

    • D. 

      Dopamine shows no selectivity between dopamine receptors in the brain and peripheral dopamine receptors.

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