Online GPAT Mock Test No.2 Developed By Dr. Anwar Shaikh
.jpg "Online GPAT Mock Test No.2 Developed By Dr. Anwar Shaikh")
Questions of this tests are prepared by Dr. Aman Upaganlawar Prof. Of Pharmacology of SSDJ college of Pharmacy, Chandwad, Dist. Nashik and Mr. Khan Majid Shabbir, Assit. Professor of Pharm. Chemistry J. D. Pawar College of Pharmacy, Manur Kalwan. NashikTotal Questions:50, Marks: 200, Each correct Answer: 4 marks, Each Wrong Answer: -1 Mark
- 1.Intravenous, intramuscular and subcutaneous are all examples of which routes of administration?
- A.
Pulmonary administration
- B.
Parenteral administration
- C.
Otic administration
- D.
Ocular administration
- 2.What is the term used for drugs that are similar in structure to a known drug and which are used for the same purpose?
- A.
'copycat' drugs
- B.
Me-too' drugs
- C.
'derivative' drugs
- D.
'analogue' drugs
- 3.What is the term used for small molecules that bind to different regions of a binding site?
- A.
Epimers
- B.
Isomers
- C.
Isotopes
- D.
Epitopes
- 4.What sort of receptor is the muscarinic receptor?
- A.
A G-protein coupled receptor
- B.
A kinase linked receptor
- C.
An intracellular receptor
- D.
An ion channel
- 5.Which of the following is not an endogenous lead compound?
- A.
Neurotransmitter
- B.
Alkaloid
- C.
Hormone
- D.
Modulator
- 6.What is meant by a lead compound in medicinal chemistry?
- A.
A drug containing the element lead.
- B.
A leading drug in a particular area of medicine.
- C.
A compound that acts as the starting point for drug design and development.
- D.
A drug which is normally the first to be prescribed for a particular ailment.
- 7.Which of the following needs to be established before the search for a lead compound takes place?
- A.
The pharmacophore
- B.
Structure-activity relationships
- C.
A bioassay
- D.
Patents
- 8.What does the symbol P represent in a QSAR equation?
- A.
PH
- B.
Plasma concentration
- C.
Partition coefficient
- D.
Prodrug
- 9.What is the symbol π in a QSAR equation?
- A.
The hydrophobicity of the molecule
- B.
The electronic effect of a substituent
- C.
The substituent hydrophobicity constant
- D.
A measure of the steric properties for a substituent
- 10.What term is used to indicate the ability of a cancer to invade other parts of the body and to produce secondary tumours?
- A.
Carcinogenesis
- B.
Apoptosis
- C.
Metastasis
- D.
Mutagenesis
- 11.Which molecules are involved in the anchoring of cells to an extracellular matrix?
- A.
Integrins
- B.
Interleukins
- C.
Angiostatin
- D.
Cyclins
- 12.Cyclophosphamide is commonly used in anticancer therapy.
- A.
It is relatively non-toxic.
- B.
It acts as a prodrug.
- C.
It cannot be taken orally.
- D.
The structure is metabolised to release acrolein.
- 13.The drug is useful in terminating atrial but not ventricular tachycardias.
- A.
Flecanide
- B.
Sotalol
- C.
Lidocaine
- D.
Verapamil
- 14.The drug is contraindicated in patient with moderate to severe heart failure.
- A.
Nifedipine
- B.
Verapamil
- C.
Both
- D.
Note of above
- 15.The drug is class IA antiarrhythmic drug.
- A.
Sotalol
- B.
Propranolon
- C.
Verapamil
- D.
Quinidine
- 16.All of the folloing effects of ACE inhibitors are helpful in heart failure Except
- A.
They decrease afterload
- B.
They Increase circulating catecholamine level
- C.
They reduce reactive myocardial hypertrophy
- D.
Increase B1 adrenoceptor density
- 17.Drug most commonly used in chronic heart failure is
- A.
Cardiac glycoside
- B.
Diuretics
- C.
ACEI
- D.
All
- 18.In very severe digitalis intoxication the best choice is to use
- A.
Digibind
- B.
Lidocaine
- C.
Oral potassium supplementation
- D.
Reduces the dose of
- 19.All of the following are normally involved in the pathogenesis of heart failure Except
- A.
A cardiac lesion that impair cardiac output
- B.
An increase in peripheral vascular resistance
- C.
Decrease in preload
- D.
Increase in sodium and potassium retention
- 20.All the statements regarding cardiac glycoside are true Except
- A.
Digoxin is a mild inotropic
- B.
Digoxin increases vagal tone
- C.
Digoxin has longer half life than digitoxin
- D.
Digoxin acts by inhibiting Na+/K+ ATPases
- 21.Which of the following is not an endogenous compound?
- A.
Dopamine
- B.
Endorphins
- C.
Noradrenaline
- D.
Desipramine
- 22.Which of the following drugs was not isolated from a natural source?
- A.
Quinine
- B.
Morphine
- C.
Isoniazid
- D.
Artemisinin
- 23.What sort of receptor is the nicotinic receptor?
- A.
A G-protein coupled receptor
- B.
A kinase linked receptor
- C.
An intracellular receptor
- D.
An ion channel
- 24.Commercially what was the use of Parathione ?
- A.
A medicine in the treatment of glaucoma
- B.
An antidote to anticholinesterase poisoning
- C.
An insecticide
- D.
A medicine in the treatment of Alzheimer's disease
- 25.Which of the following inhibits angiogenesis?
- A.
VEGF
- B.
FGF-2
- C.
Angiostatin
- D.
Interleukin-6
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