Pharmacology - Block 2

104 Questions | Total Attempts: 73

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Pharmacology - Block 2


Questions and Answers
  • 1. 
    Which enzyme controls the rate limiting step of serotonin synthesis?
    • A. 

      Monoamine Oxidase

    • B. 

      Tryptophan Hydroxylase

    • C. 

      L-aromatic amino acid decarboxylase

    • D. 

      Aldehyde Reductase

  • 2. 
    Which of the following is the only ionotropic 5-HT receptor?
    • A. 

      5-HT1A

    • B. 

      5-HT2A

    • C. 

      5-HT3A

    • D. 

      5-HT4A

  • 3. 
    Which of the following dopamine receptors is Gs coupled?
    • A. 

      D1

    • B. 

      D2

    • C. 

      D3

    • D. 

      D4

  • 4. 
    Which of the following is not properly matched based on the agonism of the receptor and its effect?
    • A. 

      D1;Renal Vasodilation

    • B. 

      D2; Increased GI motility

    • C. 

      5HT2A; Bronchoconstriction

    • D. 

      5HT2; Vasoconstriction

  • 5. 
    When dopamine is used therapeutically, as the plasma concentration increases it first activates _____ receptors, then ____ receptors, then _______ receptors.
    • A. 

      D2, alpha 1, beta 1

    • B. 

      D1, alpha 1, beta 1

    • C. 

      D1, beta 1, alpha 1

    • D. 

      Beta 1, alpha 1, D1

  • 6. 
    Aripiprazole is a partial agonist and D2 and what other receptor?
    • A. 

      D1

    • B. 

      5-HT1A

    • C. 

      5-HT3A

    • D. 

      5-HT2A

  • 7. 
    Which of the following is not a formulation of Sumatriptin?
    • A. 

      SQ

    • B. 

      IV

    • C. 

      Rectal

    • D. 

      Nasal

  • 8. 
    Fenoldopam binds to which receptor to promote renal vasodilation?
    • A. 

      D1

    • B. 

      D2

    • C. 

      5-HT3

    • D. 

      5-HT4

  • 9. 
    Which of the following is a melatonin agonist used to treat insomnia?
    • A. 

      Aripiprazole

    • B. 

      Melatocin

    • C. 

      Somnitonin

    • D. 

      Ramelteon

  • 10. 
    _____________, used in the treatment of GERD and gastric ulcers, is/are metabolized primarily by CYP ___, an enzyme in which some Asian populations have diminished activity.
    • A. 

      H2 Antagonists; 2C9

    • B. 

      Antacids; 3A4

    • C. 

      Proton Pump Inhibitors; 2C19

    • D. 

      Proton Pump Inhibitors; 2C9

  • 11. 
    Which of the following is true involving the mechanism of action of Proton Pump Inhibitors?
    • A. 

      Enteric coated formulations are used so that the drugs are absorbed in the large intestine

    • B. 

      They bind reversibly to the H+-K+-ATPase pump, inhibiting the production of acid

    • C. 

      The drugs are activated in the basic pH of the small intestine

    • D. 

      The drugs become active when protonated

  • 12. 
    Which of the following Proton Pump inhibitors is not available parenterally?
    • A. 

      Esomeprazole

    • B. 

      Omeprazole

    • C. 

      Lansoprazole

    • D. 

      Pantoprazole

  • 13. 
    Which of the following PPI's is not a prodrug?
    • A. 

      Esomeprazole

    • B. 

      Dexlansoprazole

    • C. 

      Rabeprazole

    • D. 

      All PPI's are prodrugs

  • 14. 
    What is the mechanism behind NSAID's potential to be ulcerogenic?
    • A. 

      They inhibit the formation of prostaglandins.

    • B. 

      They are EP3 antagonists that inhibit the production of mucus and bicarb and stimulate acid production

    • C. 

      They are strong acids when they dissociate in the stomach

    • D. 

      None of the above

  • 15. 
    Which of the following is not a formulation of Proton Pump Inhibitors?
    • A. 

      Enteric-coated tablets

    • B. 

      Enteric-coated drugs contained inside gelatin capsules

    • C. 

      Enteric-coated granules in powder form for suspension

    • D. 

      Powdered drug combined with Sodium Bicarbonate

    • E. 

      All of the above are formulations of PPI's

  • 16. 
    Which of the following H2 antagonists have negligible CYP affinity? (Check all that apply)
    • A. 

      Famotidine

    • B. 

      Cimetidine

    • C. 

      Ranitidine

    • D. 

      Nizatidine

  • 17. 
    Which of the following H2 antagonists has the greatest potency relative to cimetidine?
    • A. 

      Famotidine

    • B. 

      Cimetidine

    • C. 

      Ranitidine

    • D. 

      Nizatidine

  • 18. 
    Which of the following regarding H2 antagonist toxicities is true?
    • A. 

      CNS effects are common with all dosage forms

    • B. 

      Hypergastrinemia does not occur in these medications, as only one pathway of acid production is inhibited

    • C. 

      Cimetidine increases estradiol levels

    • D. 

      Cimetidine can decrease prolactin levels

  • 19. 
    Misoprostol binds to which receptor to exert its pharmacological effect?
    • A. 

      H2

    • B. 

      M3

    • C. 

      EP3

    • D. 

      CCK2

  • 20. 
    What is/are the reason(s) that misoprostol is not used very much? (Check all that apply)
    • A. 

      Its toxicities make it not very desirable

    • B. 

      It is not palatable

    • C. 

      It was taken off the market

    • D. 

      It must be dosed QID

  • 21. 
    Which of the following is not a toxicity concern for misoprostol?
    • A. 

      Diarrhea in 30% of patients

    • B. 

      Constipation in 30% of patients

    • C. 

      Exacerbation of IBD

    • D. 

      Increased uterine contractility

  • 22. 
    Which of the following does not need to be activated to exert biological activity?
    • A. 

      Misoprostol

    • B. 

      Proton Pump Inhibitors

    • C. 

      Sucralfate

    • D. 

      Antacids

  • 23. 
    Which of the following antacids would you expect to cause belching? (Check all that apply)
    • A. 

      Calcium Carbonate

    • B. 

      Magnesium Hydroxide

    • C. 

      Aluminum Hydroxide

    • D. 

      Sodium Bicarbonate

  • 24. 
    Antacids react with HCl to form a salt plus ________ or ________.
    • A. 

      H2O;HCO3

    • B. 

      CO2;HCO3

    • C. 

      O2; H2O

    • D. 

      H2O;CO2

  • 25. 
    Which of the following is not a symptom of Milk-Alkali syndrome?
    • A. 

      Hypercalcemia

    • B. 

      Decreased parathyroid hormone

    • C. 

      Renal insufficiency

    • D. 

      Metabolic Acidosis