Ocular Pharm Mt 1: Opthalmic Drug Formulations + Drug Delivery

33 Questions | Total Attempts: 82

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Drug Quizzes & Trivia

P. 30-46 (start pg. 34)


Questions and Answers
  • 1. 
    Define Fick's Law of Diffusion (OT).
  • 2. 
    Describe how loteprednol (a corticosteroid) has fewer potential side effects in the eye.
  • 3. 
    Describe certain tips that can be used to better administer solutions and suspensions.
  • 4. 
    _____ drugs absorbed slowly through the lens cortex.
  • 5. 
    What structure acts as a barrier preventing drugs from entering the vitreous?
    • A. 

      Iris

    • B. 

      Posterior chamber

    • C. 

      Lens

    • D. 

      CB

  • 6. 
    Cataract formation can be incrased with which of the following drugs?
    • A. 

      Miotics

    • B. 

      Mydriatics

    • C. 

      Steroids

    • D. 

      Barbituates

    • E. 

      Phenothiazines

  • 7. 
    Which of the following drugs can cause retinal toxicity?
    • A. 

      Fluroquinolones

    • B. 

      Mydriatics

    • C. 

      Phenothiazines

    • D. 

      Digoxin

    • E. 

      Tetracyclines

    • F. 

      Quinine

    • G. 

      Sildenafil

  • 8. 
    Which of the following drugs can cross through the retina and acheive concentrations in the vitreous/posterior segment?
    • A. 

      Fluroquinolones

    • B. 

      Tetracyclines

    • C. 

      Linezolid

    • D. 

      Fluconazole

    • E. 

      Mydriatics

    • F. 

      Voriconazole

  • 9. 
    Which of the following drugs can have toxic effects on the ON tissue resulitng in optic neuritis?
    • A. 

      Ethambutol

    • B. 

      Isoniazid

    • C. 

      Stretomycin

    • D. 

      Fluroquinolones

    • E. 

      Penicillins

    • F. 

      Digoxin

    • G. 

      Sulfonamides

  • 10. 
    Corneal absoroption depends on tear film concentration of the drug immediately after drug installation.
    • A. 

      True

    • B. 

      False

  • 11. 
    The majority of corneal drug deposit eventually enters the _____.
    • A. 

      CB

    • B. 

      Lens

    • C. 

      Aqueous humor

    • D. 

      Retina

  • 12. 
    ________ influences which tissues act as barriers and which act as resevoirs? 
  • 13. 
    Rates of drug distribution usually depend on the rate of ______ between and within compartments.
    • A. 

      Active transport

    • B. 

      Passive diffusion

    • C. 

      Carrier mediated diffusion

  • 14. 
    Zero order kinetics are much more common in ocular drug movement
    • A. 

      True

    • B. 

      False

  • 15. 
    Which of the following are prodrugs?
    • A. 

      Latanoprost

    • B. 

      Prednisone

    • C. 

      Loprimil

    • D. 

      Travoprost

  • 16. 
    What is often added to drugs to prevent oxidation and microbial contamination?
  • 17. 
    Drugs in an acidic medium can be less stable.
    • A. 

      True

    • B. 

      False

  • 18. 
    290 mOsm is equivalent to ____% saline.
  • 19. 
    Commercial drop size can vary between _____microL.
  • 20. 
    Unit-dose dispensers (single use) have perservatives so they can be stored for extensive periods of time.
    • A. 

      True

    • B. 

      False

  • 21. 
    How long should you wait between instililng an ophthalmic solution and an ophthalmic ointment?
  • 22. 
    Pilocarpine 4% in a carbomer vehicle is a type of ___?
    • A. 

      Suspension

    • B. 

      Lid scrub

    • C. 

      Drop

    • D. 

      Gel

  • 23. 
    What are the potential disadvantages of gels?
    • A. 

      Superficial corneal haze

    • B. 

      Optic neuritis

    • C. 

      Weak ocular hypotensive effects

    • D. 

      Superficial puntate keratitis

    • E. 

      Corneal ulcers

  • 24. 
    A thicker hydrogel lens delivers a greater proportion to the cornea than a thicker lens.
    • A. 

      True

    • B. 

      False

  • 25. 
    What are 2 medial conditions for which the use of lid scrubs are generally recommended?
    • A. 

      Corneal abrasions

    • B. 

      Seborrheic blepharitis

    • C. 

      Infectious belpharitis

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