CVS Test 14 July 2014

15 Questions | Total Attempts: 62

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CVS Test 14 July 2014

Questions and Answers
  • 1. 
    Hermida, et al conducted a prospective, randomised, open-label, blinded end-point trial into the effect of missing one dose of valsartan compared to enalapril using ambulatory blood pressure monitoring.
    • A. 

      True

    • B. 

      False

  • 2. 
    International Guidelines recommend the use of once daily antihypertensive drugs with 24-hour efficacy because:(choose all that apply)
    • A. 

      Compliance is an issue

    • B. 

      Fewer adverse-affects are demonstrated

    • C. 

      More consistent BP control is demonstrated

    • D. 

      None of the above

  • 3. 
    Which one of the following statements is TRUE regarding the Hermida, et al study?
    • A. 

      Valsartan 160mg/d and enalapril 20mg/d were compared during this study

    • B. 

      Valsartan 80mg/d and enalapril 20mg/d were compared during this study

    • C. 

      Valsartan 160mg/d and enalapril 10mg/d were compared during this study

    • D. 

      Valsartan 80mg/d and enalapril 10mg/d were compared during this study

  • 4. 
    In the Hermida, et al study blood pressure reduction was significantly higher for valsartan compared to enalapril in the final four hours of the first 24 hours of ABPM.
    • A. 

      True

    • B. 

      False

  • 5. 
    In the Hermida, et al study what was the mean change in blood pressure between the first and second ABPM periods with valsartan compared to enalapril?
    • A. 

      2,1/1.4 mmHg vs.5,5/3,8 mmHg

    • B. 

      2,1/1.8 mmHg vs.3,8/2,1 mmHg

    • C. 

      3,8/2,1 mmHg vs.5,5/2,1 mmHg

    • D. 

      None of the above

  • 6. 
    HYVET stands for "Hypertension in the Very Elderly Trial"
    • A. 

      True

    • B. 

      False

  • 7. 
    Which of the following statements best describes how patients were randomised in HYVET?
    • A. 

      Perindopril or matching placebo with the option of adding indapamide or matching placebo to reach the target BP of 150/80 mmHg.

    • B. 

      Indapamide or matching placebo with the option of adding perindopril 2/4 mg daily or matching placebo to reach the target BP of 150/80 mmHg.

    • C. 

      Indapamide or perindopril to reach the target BP of 150/80 mmHg.

    • D. 

      None of the above

  • 8. 
    Which of the following statements is TRUE with regards to the patients enrolled in HYVET?
    • A. 

      Patients had a mean age of 83,6 years

    • B. 

      Patients had a mean blood pressure while sitting of 173/90,8 mmHg

    • C. 

      11,8% of patients had a history of cardiocvascular disease

    • D. 

      All of the above

  • 9. 
    HYVET demonstrated a 30% reduction in the rate of fatal or nonfatal stroke in the active treatment group.
    • A. 

      True

    • B. 

      False

  • 10. 
    Which of the following is a conclusion of HYVET?
    • A. 

      Indapamide SR 1,5 mg, with or without perindopril, is beneficial in persons 80 years and older in achieving a target BP of 150/80 mmHg.

    • B. 

      Indapamide SR 1,5 mg, with or without perindopril, in persons 80 years and older is associated with reduced risks of death from stroke.

    • C. 

      Indapamide SR 1,5 mg, with or without perindopril, in persons 80 years and older is associated with reduced risks of death from any cause.

    • D. 

      All of the above

  • 11. 
    Masked Uncontrolled Hypertension can be defined as "sub-optimal BP levels as measured by ABPM but NP is considered controlled to clinic BP targets".
    • A. 

      True

    • B. 

      False

  • 12. 
    Which of the following best describe the current UK NICE Guideline definition of hypertension, using ABPM?
    • A. 

      Daytime mean ABPM of ≥ 135/85 mmHg

    • B. 

      Daytime mean ABPM of ≥ 130/85 mmHg

    • C. 

      Daytime mean ABPM of ≥ 140/85 mmHg

    • D. 

      Daytime mean ABPM of ≥ 140/90 mmHg

  • 13. 
    In the Banegas, et al study what proportion of treated and controlled hypertensive patients were indentified as having masked uncontrolled hypertension (MUCH)?
    • A. 

      25,5%

    • B. 

      16,6%

    • C. 

      31,1%

    • D. 

      23,3%

  • 14. 
    In the Banegas, et al study the prevalence of MUCH was significantly lower in male patients.
    • A. 

      True

    • B. 

      False

  • 15. 
    In the Banegas, et al study the prevalence of MUCH was:
    • A. 

      Significantly higher in patients with high cardiovascular risk factors

    • B. 

      Not significantly different when comparing administration of one drug versus ≥ 2 drugs.

    • C. 

      Clearly higher when the clinic BP was closer to the BP control threshold.

    • D. 

      All of the above

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