CVS Test 14 July 2014

15 Questions | By Jbekkercronje | Updated: Mar 20, 2022 | Attempts: 113

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1.

Hermida, et al conducted a prospective, randomised, open-label, blinded end-point trial into the effect of missing one dose of valsartan compared to enalapril using ambulatory blood pressure monitoring.
- A.
  
  True
- B.
  
  False
2.

International Guidelines recommend the use of once daily antihypertensive drugs with 24-hour efficacy because:(choose all that apply)
- A.
  
  Compliance is an issue
- B.
  
  Fewer adverse-affects are demonstrated
- C.
  
  More consistent BP control is demonstrated
- D.
  
  None of the above
3.

Which one of the following statements is TRUE regarding the Hermida, et al study?
- A.
  
  Valsartan 160mg/d and enalapril 20mg/d were compared during this study
- B.
  
  Valsartan 80mg/d and enalapril 20mg/d were compared during this study
- C.
  
  Valsartan 160mg/d and enalapril 10mg/d were compared during this study
- D.
  
  Valsartan 80mg/d and enalapril 10mg/d were compared during this study
4.

In the Hermida, et al study blood pressure reduction was significantly higher for valsartan compared to enalapril in the final four hours of the first 24 hours of ABPM.
- A.
  
  True
- B.
  
  False
5.

In the Hermida, et al study what was the mean change in blood pressure between the first and second ABPM periods with valsartan compared to enalapril?
- A.
  
  2,1/1.4 mmHg vs.5,5/3,8 mmHg
- B.
  
  2,1/1.8 mmHg vs.3,8/2,1 mmHg
- C.
  
  3,8/2,1 mmHg vs.5,5/2,1 mmHg
- D.
  
  None of the above
6.

HYVET stands for "Hypertension in the Very Elderly Trial"
- A.
  
  True
- B.
  
  False
7.

Which of the following statements best describes how patients were randomised in HYVET?
- A.
  
  Perindopril or matching placebo with the option of adding indapamide or matching placebo to reach the target BP of 150/80 mmHg.
- B.
  
  Indapamide or matching placebo with the option of adding perindopril 2/4 mg daily or matching placebo to reach the target BP of 150/80 mmHg.
- C.
  
  Indapamide or perindopril to reach the target BP of 150/80 mmHg.
- D.
  
  None of the above
8.

Which of the following statements is TRUE with regards to the patients enrolled in HYVET?
- A.
  
  Patients had a mean age of 83,6 years
- B.
  
  Patients had a mean blood pressure while sitting of 173/90,8 mmHg
- C.
  
  11,8% of patients had a history of cardiocvascular disease
- D.
  
  All of the above
9.

HYVET demonstrated a 30% reduction in the rate of fatal or nonfatal stroke in the active treatment group.
- A.
  
  True
- B.
  
  False
10.

Which of the following is a conclusion of HYVET?
- A.
  
  Indapamide SR 1,5 mg, with or without perindopril, is beneficial in persons 80 years and older in achieving a target BP of 150/80 mmHg.
- B.
  
  Indapamide SR 1,5 mg, with or without perindopril, in persons 80 years and older is associated with reduced risks of death from stroke.
- C.
  
  Indapamide SR 1,5 mg, with or without perindopril, in persons 80 years and older is associated with reduced risks of death from any cause.
- D.
  
  All of the above
11.

Masked Uncontrolled Hypertension can be defined as "sub-optimal BP levels as measured by ABPM but NP is considered controlled to clinic BP targets".
- A.
  
  True
- B.
  
  False
12.

Which of the following best describe the current UK NICE Guideline definition of hypertension, using ABPM?
- A.
  
  Daytime mean ABPM of ≥ 135/85 mmHg
- B.
  
  Daytime mean ABPM of ≥ 130/85 mmHg
- C.
  
  Daytime mean ABPM of ≥ 140/85 mmHg
- D.
  
  Daytime mean ABPM of ≥ 140/90 mmHg
13.

In the Banegas, et al study what proportion of treated and controlled hypertensive patients were indentified as having masked uncontrolled hypertension (MUCH)?
- A.
  
  25,5%
- B.
  
  16,6%
- C.
  
  31,1%
- D.
  
  23,3%
14.

In the Banegas, et al study the prevalence of MUCH was significantly lower in male patients.
- A.
  
  True
- B.
  
  False
15.

In the Banegas, et al study the prevalence of MUCH was:
- A.
  
  Significantly higher in patients with high cardiovascular risk factors
- B.
  
  Not significantly different when comparing administration of one drug versus ≥ 2 drugs.
- C.
  
  Clearly higher when the clinic BP was closer to the BP control threshold.
- D.
  
  All of the above