Haematology Quiz
- 1.
Which of these is not true?
- A.
Thrombocytes are formed in the bone marrow
- B.
Platelets can contract via myosin and actin
- C.
Thrombocytes store Ca++
- D.
Platelets reproduce in the golgi apparatus of Megakaryocytes
Correct Answer
D. Platelets reproduce in the golgi apparatus of Megakaryocytes -
- 2.
Which of these is true?
- A.
Platelets have a half life of 8-12 days
- B.
Platelets are not capable of activating eachother
- C.
Plug formation is efficient for all sizes of openings in vessel walls/ structures
- D.
Platelets don't play a role in cloth retraction
Correct Answer
A. Platelets have a half life of 8-12 days -
- 3.
Which is false?
- A.
Blood cloths become invaded by fibroblasts which further form connective tissue
- B.
Calcium is facto V
- C.
Factor XIII is fibrin stabilising factor
- D.
Factor I is Fibrinogen
Correct Answer
B. Calcium is facto V -
- 4.
What is false?
- A.
Prothrombin receptors are present on platelets
- B.
Prothrombin is formed in the Liver
- C.
Vitamin K deficiency results in a bleeding tendency
- D.
Fibrinogen is formed in the bone marrow
Correct Answer
D. Fibrinogen is formed in the bone marrow -
- 5.
Which of these is false?
- A.
Serum can not clot
- B.
Clot retraction is carried out by Platelets, Ca++ and Thrombin
- C.
A wettable surface like glass can convert factor XII to XIIa
- D.
Fibrinogen is formed in the bone marrow
Correct Answer
D. Fibrinogen is formed in the bone marrow -
- 6.
Which of these is the correct order for the Extrinsic pathway?
- A.
Tissue factor release - Factor X activation - Thrombin - prothrombin
- B.
Prothrombin - Thrombin - Factor X activation - Tissue factor release
- C.
Tissue factor release - Factor X activation - Prothrombin - Thrombin
- D.
Factor X activation - Prothrombin - Thrombin - Tissue factor release
Correct Answer
C. Tissue factor release - Factor X activation - Prothrombin - Thrombin -
- 7.
Which of these is false about Heparin?
- A.
Heparin is highly positively charged
- B.
Alone, it is useless as an anticoagulant
- C.
Factors XII, XI, X, and IX are removed by heparin and antithrombin III
- D.
Heparin in high amounts inhibits clot formation
Correct Answer
A. Heparin is highly positively charged -
- 8.
Which one do you like?
- A.
Haemophilia A is caused by a deficiency of Factor VIII
- B.
Splenectomy is always a cure for thrombocytopenia
- C.
Factor VIII can be injected into a haemophilia A patient to effectively cure for a short while
- D.
Minute Haemorrhages are apparent throughout the body in Thrombocytopenia
Correct Answer
B. Splenectomy is always a cure for thrombocytopenia -
- 9.
During foetal life B lymphocytes undrgo preprocessing in
- A.
The bone marrow
- B.
The spleen
- C.
The liver
- D.
The pancreas
Correct Answer
C. The liver -
- 10.
Which of the following statements about the spleen is false:
- A.
It has a vast number of macrophages lodged in its trabeculated region and venous sinusoids.
- B.
It is responsible for defending the body against blood born organisims
- C.
It is a hypoxic and alkaline environment
- D.
It is involved in haemolytic anaemias
Correct Answer
C. It is a hypoxic and alkaline environment -
- 11.
Which of the toxins mentioned below targets specifically parasite larvae
- A.
Major basic protein
- B.
Hypochlorite
- C.
Lysozyme
- D.
Perforins
Correct Answer
A. Major basic protein -
- 12.
Which of the Interleukins mentioned below is not secreted by T-Helper cells:
- A.
IL-2
- B.
IL-1
- C.
IL-6
- D.
IL-5
Correct Answer
B. IL-1 -
- 13.
Which of the Interleukins mentioned below is not part of the B-cell stimulating group:
- A.
IL-3
- B.
IL-4
- C.
IL-5
- D.
IL-6
Correct Answer
A. IL-3 -
- 14.
In the complement cascade which of the following combinations is refered to a fluid phase C3 convertase:
- A.
C3bBb
- B.
C3(H20)Bb
- C.
C3bBbC3b
- D.
C4bC2b
Correct Answer
B. C3(H20)Bb -
- 15.
Which of the following statements is false:
- A.
C5a is a chemotactic agent
- B.
C5a and C3a are activators of phagocytosis
- C.
C4b has anti-viral properties
- D.
C4a can act as an opsinizing agent
Correct Answer
D. C4a can act as an opsinizing agent -
- 16.
The protein Factor H is key in regulating the complement cascade, it is responsible for
- A.
Cleaving fluid phase C3 convertase
- B.
Binding to free C3b
- C.
Binding to free Factor D
- D.
Causing the dissociation of C1 from the gamma CH2
Correct Answer
B. Binding to free C3b -
- 17.
Which of the following substances is not involved in the allergic response
- A.
Bradykinin
- B.
Histamine
- C.
Eosinophile chemotactic factor
- D.
Il-4
Correct Answer
D. Il-4 -
- 18.
In the process of somatic hypermutation, which of these enzymes is responsible for causing the DNA damage:
- A.
Activation induced Kinase
- B.
Thymine-DNA Glycosylase
- C.
Error Prone DNA Polymerase
- D.
DNA-Uracil Glycosylase
Correct Answer
D. DNA-Uracil Glycosylase -
- 19.
With respect to the process of class switching, which statment is false:
- A.
IgM can become any other class
- B.
IgG type 3 can become IgG type 1
- C.
IgA1 can become IgA2
- D.
Switch sites are present before the gene coding for every class except for the Delta gene
Correct Answer
A. IgM can become any other class -
- 20.
In inflammation a number of responses occur in sequential order, choose the right sequence:
- A.
Tissue Macrophage activation-Macrophge invasion-Neutrophile invasion-Bone marrow activation
- B.
Tissue Macrophage activation-Bone Marrow activation-Neutrophile Invasion-Macrophage invasion
- C.
Neutrophile Invasion- Macrophage Invasion-Bone Marrow activation-Tissue Macrophage activation
- D.
Tissue Macrophage activation-Neutrophile invasion-Macrophage invasion-Bone Marrow activation
Correct Answer
D. Tissue Macrophage activation-Neutrophile invasion-Macrophage invasion-Bone Marrow activation -
- 21.
Which of the following is not involved in bone marrow activation:
- A.
IL-1
- B.
TNF
- C.
G-CSF
- D.
IL-2
Correct Answer
B. TNF -
- 22.
Regarding the process of phagocytosis in neutrophils and Macrophages, choose the statment that is most correct:
- A.
Both neutrophils and macrophages can phagocytose and destroy all types of bacteria
- B.
Both are capable of excreting the products of phagocytosis by exocytosis
- C.
Both Make use of peroxisomes to aid in the digestion process
- D.
Both make use of the enzyme myeloperoxidase to form OH-. radicals
Correct Answer
D. Both make use of the enzyme myeloperoxidase to form OH-. radicals -
- 23.
In anaphylaxis,a person most often dies of
- A.
Suffocation due to histamine
- B.
Suffocation due to the slow reacting substance of anaphylaxis
- C.
Circulatory shock due to histamine
- D.
Circulatory shock due to the slow reacting substance of anaphylaxis
Correct Answer
C. Circulatory shock due to histamine -
- 24.
In the delayed type allergic reaction, the culprit with resapect to the damage is most often:
- A.
T-Helper cells
- B.
IgEs and Basophils
- C.
Cytotoxic T-cells
- D.
Neutrophils
Correct Answer
B. IgEs and Basophils -
- 25.
In transfusion medicine platelets are normally stored at:
- A.
5 degrees celcius
- B.
15 degrees celcius
- C.
22 degrees celcius
- D.
-30 degrees celcius
Correct Answer
C. 22 degrees celcius -
- 26.
Which of the following is not true about transfusiin medicine:
- A.
The red blood cell storage leision can be due to white blood cells present in the blood
- B.
The red blood cells in stored blood may develop an abnormaly low affinity for oxygen
- C.
The red blood cells may be damaged by ROS while in storage
- D.
The blood transfused will be more acidic than when collected.
Correct Answer
B. The red blood cells in stored blood may develop an abnormaly low affinity for oxygen -
- 27.
The complement protein C1 is:
- A.
Involved in biding to alpha CH2 regions on the heavy chains of antibodies
- B.
Composed of 2 C1r and C1s subunits as well as a C1p subunit
- C.
A zymogen that when activated catalyses the amplification loop
- D.
A complement protein involved in only the classical pathway
Correct Answer
D. A complement protein involved in only the classical pathway -
- 28.
Neurtophils are not:
- A.
Members of the granulocyte family
- B.
Responsible for releasing ROS
- C.
The first cells to respond in an inflammatory response
- D.
Able to enter a tissue by diapedisis
Correct Answer
C. The first cells to respond in an inflammatory response -
- 29.
Which of the following cells has a special receptor allowing it to bind to parasites:
- A.
Basophils
- B.
Cytotoxic T-cell
- C.
Eosinophils
- D.
Macrophages
Correct Answer
C. Eosinophils -
- 30.
The disease leukemia has many different forms, which of the following would most likely involve cells which are the most differentiated
- A.
Acute myelogenous leukemia
- B.
Chronic myelogenous leukemia
- C.
Acute Lymphoblastic leukemia
- D.
Chronic Lymphocytic leukemia
Correct Answer
D. Chronic Lymphocytic leukemia -
- 31.
The disease Myasthenia gravis is involved caused by a lack of immune tolerance, resulting in:
- A.
An attack on synovial joints
- B.
An attack on Ne Receptors on skeletal muscles
- C.
An attack on AcH receptors on skeletal muscles
- D.
An attack of the basement membrane of the glomerulus
Correct Answer
C. An attack on AcH receptors on skeletal muscles -
- 32.
The typical time spent by a monocyte in blood is:
- A.
5 days
- B.
5 hours
- C.
12 hours
- D.
7 days
Correct Answer
C. 12 hours -
- 33.
Which of the following is not involved in the defence of the respiratory tract:
- A.
Alpha defensin
- B.
IgA
- C.
Resident Macrophages
- D.
T and B lymphocytes
Correct Answer
B. IgA -
- 34.
With respect to first line of defence immunity, which of the following is not true:
- A.
The female reproductive system varies in its susceptibility to disease
- B.
The male reproductive system shares the urinary systems defences
- C.
The Skin is highly resistant to microbes by virtue of having an acidic pH
- D.
The interleukin IL-2 is part of the urinary defence system
Correct Answer
D. The interleukin IL-2 is part of the urinary defence system -
- 35.
Which of the follwoing statements about immunity is false
- A.
T-cells contribute to immunity
- B.
Immunization is passive artificial immunity
- C.
Anti-serum lasts a couple of months
- D.
Anti-serum is passive immunity
Correct Answer
B. Immunization is passive artificial immunity -
- 36.
Which of these is False
- A.
Granulocytes last 4-8 days in blood
- B.
Lymphocytes last weeks or months
- C.
Monocytes mature in blood
- D.
Monocytes last months after entering tissues
Correct Answer
C. Monocytes mature in blood -
- 37.
Which of these is true for Neutrophil Phagocytosis
- A.
The neutrophil projects Psuedopodia in one direction, which wraps around the foreign cell
- B.
A neutrophil can only ingest one bacterium before inactivating
- C.
Neutrophil Phagocytosis begins with fusion of pseudopodia with foreign particle
- D.
Fusion of pseudopodia occurs at the other end of an invaginated particle forming a phagosome
Correct Answer
D. Fusion of pseudopodia occurs at the other end of an invaginated particle forming a phagosome -
- 38.
Which of these is not an ROS
- A.
O2
- B.
H2O2
- C.
OH-
- D.
O2-
Correct Answer
A. O2 -
- 39.
Monocytes normally aren't membrane bound to which cells/tissues?
- A.
Histocytes
- B.
Lymph nodes
- C.
Kuppfer cells
- D.
Vascular endothelial cells
Correct Answer
A. Histocytes -
- 40.
Which of these is true
- A.
In the thymus, immature basophils undergo rapid division and differentiation
- B.
Self antigen presenting lymphocytes in the thymus are destroyed by a process known as Clonal Selection
- C.
Pre-Processing of B lymphocytes occurs in the Liver throughout life
- D.
Lymphocyte pre-processing occurs only shortly before birth, and slightly after
Correct Answer
D. Lymphocyte pre-processing occurs only shortly before birth, and slightly after -
- 41.
Which of these isn't secreted by Helper T-Cells (according to the notes at least)
- A.
IL-3
- B.
IL-6
- C.
IL-1
- D.
IL-4
Correct Answer
C. IL-1 -
- 42.
Which of these is true?
- A.
Memory cells are the basis of vaccination
- B.
Plasmablasts are precursors of erythrocytes
- C.
Memory cells are produced in high numbers irrespective of infection
- D.
Plasma cells undergo rapid division forming immature Plasma cells
Correct Answer
A. Memory cells are the basis of vaccination -
- 43.
Which of these is false about the Complement system:
- A.
Activated C1 is involved in the formation of C4b, C2a, C4a and C2b
- B.
C4Bp is capable of inhibiting C4b
- C.
C5 convertase is composed of C2b, C3b, C4b and C4a
- D.
C3bC4b complex promotes phagocytosis
Correct Answer
B. C4Bp is capable of inhibiting C4b -
- 44.
Which of these is false about the Lectin Pathway
- A.
Factor H inhibits only free C3b
- B.
Factor I cleaves C3b
- C.
The complement pathway is tightly regulated
- D.
MBLs and Ficolins are associated with MASPs
Correct Answer
A. Factor H inhibits only free C3b -
- 45.
Which of these is true for leukaemia
- A.
Metabolic starvation results due to the bodys extra needs to combat cancer
- B.
It is a result of Metastatic growth of Erythrocytic Tissues
- C.
There is a tendency for bleeding
- D.
Individuals die of irriversible cell damage
Correct Answer
C. There is a tendency for bleeding -
- 46.
Which of these is not an immune disease
- A.
Type 1 diabetes
- B.
Myasthenia gravis
- C.
Glomerulonephrritis
- D.
Acute Porphyria
Correct Answer
D. Acute Porphyria -
- 47.
Which of these isn't a RCA
- A.
DAF
- B.
ACR
- C.
CR1
- D.
MCP
Correct Answer
B. ACR -
- 48.
Which of these isnt an Apheresis method
- A.
Plasmaphoresis
- B.
Erythrocytapheresis
- C.
Thrombopheresis
- D.
Leukapheresis
Correct Answer
C. Thrombopheresis -
- 49.
Which of these is true for Blood Component storage
- A.
Platelets last 10 days at 4 Degrees temperature
- B.
Plasma lasts for 2 years at room temperature
- C.
Erythrocytes last for 42 days at 4 degrees celcius
- D.
Cryoprecipitate lasts for 2 years at 4 degrees
Correct Answer
C. Erythrocytes last for 42 days at 4 degrees celcius -
- 50.
Which of these is not a component of CPDA
- A.
Dextrose
- B.
NaHPO4
- C.
Adenine
- D.
Citrate
Correct Answer
B. NaHPO4 -
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Jun 15, 2014Quiz Edited by
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May 29, 2014Quiz Created by
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