Providing home-based health care in a pandemic is the definition of doing more with less. In the public health crisis following the U.S. arrival of COVID-19 providers of home and specialty infusion therapy are charged with keeping patients and staff safe while ramping up capacity to relieve the pressure from surging needs in the acute care sector. As all this is happening, everyone on the health care continuum is grappling with dire equipment shortages, expecting workforce interruptions, and preparing for the long haul.