Untitled Quiz

6 Questions

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Untitled Quiz


Questions and Answers
  • 1. 
    The major detoxification reaction involve in phase 1 are all, except
    • A. 

      Oxidation

    • B. 

      Reduction

    • C. 

      Hydrolisis

    • D. 

      Acetylation

    • E. 

      Epoxidation

  • 2. 
    The hydroxilated product of phase 1 are converted to soluble metabolites by coupling with polar agent in phase 2 of detoxification reactions by a process called conjugation. Which of the following agent is not conjugating agent?
    • A. 

      Active acetate

    • B. 

      Active sulfat

    • C. 

      Active methionine

    • D. 

      Active glucoronate

    • E. 

      Active bicarbonate

  • 3. 
    The biotransformation reaction are not only meant for removal of toxicity of foreign or endogenous compound under certain conditions the toxic potential of certain compound is rather increased (entoxification reactions). Which of the following is not an example of entoxification reaction?
    • A. 

      Conversion methanol to formate

    • B. 

      Conversion ethanol to acetate

    • C. 

      Conversion of procarcinogen to ultimate carcinogen

    • D. 

      Conversion of p methyl amino azo benzene to p dimethyl azo benzene

    • E. 

      Methylation of mercury

  • 4. 
    Phase 1 are mainly catalyzed by a class of enzymes refered as
    • A. 

      Monooxygenase

    • B. 

      Mixed function oxidases

    • C. 

      Cyp 450 system

    • D. 

      All above

    • E. 

      None

  • 5. 
    Which of the following enzymes is involved in the glucoronidation reactions ?
    • A. 

      UDP G pyro phosporilase

    • B. 

      UDP dehydrogenase

    • C. 

      UDP glucuronyl transferase

    • D. 

      Glucan transferase

    • E. 

      Glucuronidase

  • 6. 
    The general reaction catalyzed by cytochrome P450 is written as follows NADPH+H ++02+SH ------à NADP+H20+S - X ?where the substrate (S) may be a steroid, fatty acid, drug, or other chemical that has an alkane, alkene, aromatic ring, or heterocyclic ring substituent that can serve as a site for oxygenation. What is X? 
    • A. 

      O-

    • B. 

      HO’

    • C. 

      OH

    • D. 

      HOO

    • E. 

      ROS