Molecular Biology

17 Questions

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Molecular Biology Quizzes & Trivia

Questions and Answers
  • 1. 
    Which of the following wound not be considered part of your genome?
    • A. 

      Integrated retrovirus

    • B. 

      Mitochondrial DNA

    • C. 

      Vaccinia irus DNA in the cytoplasm

    • D. 

      Integrated transposon

  • 2. 
    Nucleotides provide the "building blocks" form which nucleic acids are constructed. Which of the following comninations are present in DNA:
    • A. 

      Thymine, cytosine, guanine, uracil

    • B. 

      Uracil, adenine, guanine, cytocine

    • C. 

      Cytocine, adenine, guanine, and thymine

    • D. 

      Adenine, guanine, uracil, thymine

  • 3. 
    AZT, a drug used to slpw the progression of the human immunodeficiency virus infection ahd the chemical name 3-azido-2-deoxythmididine and the structure shown below.  What is the mode of action of AZT?
    • A. 

      Inhibits protien sythesis at teh peptidyltransferase step

    • B. 

      Inhibits protein synthesis at the translocase step

    • C. 

      Inhibits DNA synthesis by inhibiting helicase and DAN "unwinding"

    • D. 

      Inhibits DNA synthesis by terminating biosynthesis of the nascent DNA molecule

  • 4. 
    Multiple isoforms of dytrophin are made in indiviuals that are homozygous for th wil type dystrophin allele.  Which of the following is behind this polymorphism?
    • A. 

      Alternative 3' polyadenylation

    • B. 

      Rapid turnover of mis-folded protiens

    • C. 

      Excisiion at the cre-lox locus

    • D. 

      Alternative splicing of the primary transcript

  • 5. 
    To which fo the termsn below does the following defination refer?" That sefment of a nucleic acid sequence that lies between 2 stop codons in the same reading fram, when translated in that reading frame"
    • A. 

      Open reading frame

    • B. 

      Reading frame

    • C. 

      Intron

    • D. 

      Exon

  • 6. 
    Congratulations! You have recently acquaired the sequence of a cloned dsDNA fragment. You need to determine if there is a protien-encoding sequnce present.  How many reading frames must you consider?
    • A. 

      1

    • B. 

      2

    • C. 

      3

    • D. 

      6

  • 7. 
    What sort of biochemical evidence had been used to support the hypothesis that new variant CJ disease in humans arosee from exposure to bovine spongiform encephalopathy?
    • A. 

      The patterns and extent of damage in different reagions of the brains of affflicted hosts

    • B. 

      The length of time involved in diease development when studied in a model host system

    • C. 

      The amoutns, sidezes and patterns of PrP27-30 accumulating in the afflicted hosts

    • D. 

      A-c have been used

    • E. 

      A-c have never been used

  • 8. 
    The antibiotic anisomycin, blocks the peptidyltransferase reaction in eukaryotes.  Which antibiotic blocks this same step in prokaryotic proein synthesis?
    • A. 

      Rifamycin

    • B. 

      Erythromycin

    • C. 

      Chloramphenicol

    • D. 

      None of the Above

  • 9. 
    In the isothermal helicase dependent amplification reaction, the helicase enzyme replaes which component or aspect of a PCR reaction?
    • A. 

      Replaces the thermostable DNA polymerase

    • B. 

      Replaces the reverse transcriptase step

    • C. 

      Replaces the thermal denaturation step

    • D. 

      It replaces the annealing step

  • 10. 
    • A. 

      Microarry analyses are most commonly used to anylyse transcript abundance

    • B. 

      norhtern blots are used to analyse RNA samples

    • C. 

      Western blots are used to analyse multiplex PCR products

    • D. 

      Southern blots are used to analyze DNA samples

  • 11. 
    Tasmanian devils are suffering sever poluation losses due to an aggressive tumor spread by tumor cells that are transmitted amoong individuals by biting.  The tumors all have the same  biarre karyotype involving loss of several chromososmes, rearrangement of others, and duplication of still others.  Which of the below phenomena, common to many cancer cells and tumors, are consistent with the situation?
    • A. 

      Tumor progression

    • B. 

      Genomic instability

    • C. 

      Cellular clonality

    • D. 

      All of the above

    • E. 

      None of the above

  • 12. 
    Which is the following is not a hallmark of most cancerous tumors?
    • A. 

      Neovascularization

    • B. 

      Rapid growth of the cancer cells

    • C. 

      Apoptosis occurs more rapidly than cell division

    • D. 

      Accumulation of mutations

  • 13. 
    In doing a paired mating test for copper toxicosis defect, only 1 puppy was obtianed, but it was phenotypically normal.  The owner is estatic, now believing his bitch is suitable for breeding stock.  What gentoype is not a possibility for the parten of uncertain genotype, with regard to the copper toxicosis defect?
    • A. 

      Homozygous normal

    • B. 

      Homozygous defective

    • C. 

      Heterozygous

    • D. 

      Diploid

  • 14. 
    Progressive retinal atrophy in Irish stters is caused by a point mutation in the phosphodiesterase b subunit that results in an amber mutaiton within the coding region fo the gene.  This is an example of:
    • A. 

      Missense mutation

    • B. 

      Nonsense mutation

    • C. 

      Frameshift mutation

    • D. 

      Deletion mutation

  • 15. 
    DNA methylation is prokaryotes seves as a sort of primitive "immune recognition".  In eukaryotes it doesn not seem to serve this purposed, but methylation patterns can be hertiable. What is this form of inheritance called?
    • A. 

      Pseudogenetic

    • B. 

      Genetics

    • C. 

      Epigenetic

  • 16. 
    In a female heterozygous for the sex-linked trait, Facto VIII hemophilia, the phenotype is bromal.  What is teh term best describing this situation, where a normal allele covers up the defect in another allele by causing the expression of at least some normal product?
    • A. 

      Discordance

    • B. 

      Complementaiton

  • 17. 
    Which of the following statements is true regarding a comparison of PCR analysis and erology in the diagnosis of infectious diseases?
    • A. 

      A positive serology result indicates previous exposure, but does not confirm active infection

    • B. 

      A positive PCR result indicates previous exposure, but does not confirm active infection

    • C. 

      A positive PCR result indicates apoptosis had occured and there is not active infeciton

    • D. 

      A postive serology result indicates an adequate immune response occured and there is no active infeciton