Trivia Questions On Tuberculosis! Quiz

25 Questions | Total Attempts: 235

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Trivia Questions On Tuberculosis! Quiz - Quiz

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Questions and Answers
  • 1. 
    In first stage of TB infection , M.tb enters and resides within alveolar macrophages and dentritic cells 
    • A. 

      True

    • B. 

      False

  • 2. 
    Person with latent TB can spread TB bacteria to others 
    • A. 

      True

    • B. 

      False

  • 3. 
    Infectious person with TB disease: 
    • A. 

      Sputum smears and cultures may be positive 

    • B. 

      May require respiratory isolation 

    • C. 

      Radiograph may be abnormal 

    • D. 

      All of the above 

  • 4. 
    There are two main reasons described for a reactivation of latent TB : 
    • A. 

      A decline in the host’s immunity due to genetic or environmental causes 

    • B. 

      Failure to develop and maintain imune signals 

    • C. 

      Have another infection with TB 

    • D. 

      A+C 

    • E. 

      A+B 

  • 5. 
    The most common site of TB disease is pulmonary 
    • A. 

      True

    • B. 

      False

  • 6. 
    First line agents for treatment of TB 
    • A. 

      Pyrazinamide

    • B. 

      Ethambutol

    • C. 

      Rifampin

    • D. 

      All of the above 

  • 7. 
    TB infection cannot spread to the tissue surrounding brain and spinal cord
    • A. 

      True

    • B. 

      False

  • 8. 
    Drug for atypical mycobacteria
    • A. 

      Linezolid

    • B. 

      Cycloserine 

    • C. 

      Macrolides

    • D. 

      All of the above 

  • 9. 
    In HIV-infected persons, extra pulmonary TB disease is often accompanied by pulmonary TB 
    • A. 

      True

    • B. 

      False

  • 10. 
    Isoniazid 
    • A. 

      Active against extracellular and intracellular organisms 

    • B. 

      Activated by mycobacterial catalase peroxidase 

    • C. 

      Inhibit mycolic acid synthesis 

    • D. 

      All of the above 

  • 11. 
    Resistance mechanism of isoniazid: 
    • A. 

      Mutations resulting in over expression of inhA gene 

    • B. 

      Mutation or deletion of KatG gene 

    • C. 

      Mutation in kasA gene

    • D. 

      Mutation resulting in over expression of aphc gene 

    • E. 

      All of the above 

  • 12. 
    Aluminum containing antacids affect isoniazid abs. 
    • A. 

      True

    • B. 

      False

  • 13. 
    Isoniazid can cause neuropathy so we give pyridoxine with it to decrease the risk of neuropathy 
    • A. 

      True

    • B. 

      False

  • 14. 
    MOA of rifampin
    • A. 

      Intercalation 

    • B. 

      Binding to DNA polymerase 

    • C. 

      Inhibition of DNA transcription by binding to B-subunit of the RNA polymerase 

    • D. 

      None of the mentioned 

  • 15. 
    Clinical application of rifampin 
    • A. 

      Elimination of meningococcal carriage 

    • B. 

      Arthralgia

    • C. 

      Hyperuricemia 

    • D. 

      None of the mentioned 

  • 16. 
    Pyrazinamide is biliary excreted
    • A. 

      True

    • B. 

      False

  • 17. 
    Streptomycin 
    • A. 

      IV/IM administrated

    • B. 

      Ototoxicit is One of the adverse reactions 

    • C. 

      Interfere with the binding of formyl-methionyl-tRNA to 30s subunit 

    • D. 

      All of the above 

  • 18. 
    We give pyridoxine to decrease the neurotoxicity of ethionamide 
    • A. 

      True

    • B. 

      False

  • 19. 
    Cycloserine 
    • A. 

      DNA polymerase inhibitor 

    • B. 

      An analogue of D-alanine 

    • C. 

      Hepatically eliminated 

    • D. 

      None of the mentioned 

  • 20. 
    Aminosalicilic acid is a folate synthesis antagonist 
    • A. 

      True

    • B. 

      False

  • 21. 
    Kanamycin and capreomycin are better tolerated than amikacin
    • A. 

      True

    • B. 

      False

  • 22. 
    We use linzolid as a last resort 
    • A. 

      True

    • B. 

      False

  • 23. 
    Rifambutin is a rifampin derivative but there’s no cross resistance 
    • A. 

      True

    • B. 

      False

  • 24. 
    Dapsone 
    • A. 

      Folate synthesis inhibitor 

    • B. 

      Dose adjustment in renal failure

    • C. 

      Hemolysis and pruritis are adverse effects 

    • D. 

      A+C

    • E. 

      All of the above 

  • 25. 
    Clofazimine 
    • A. 

      Alternative to dapsone 

    • B. 

      Renally excreted 

    • C. 

      Skin discoloration and GI intolerance are adverse effects 

    • D. 

      A+C

    • E. 

      All of the above 

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