Effects And Uses Of Drugs

40 Questions | By Anm_1010 | Last updated: Mar 21, 2022 | Total Attempts: 65

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1.

Which of the following is not a function of drugs?
- A.
  
  Diagnosis
- B.
  
  Prevention
- C.
  
  Treatment
- D.
  
  None of the above
2.

Which of the following is not one of the body control systems on which drugs act upon?
- A.
  
  Receptors
- B.
  
  Ion channels
- C.
  
  Genetic apparatus
- D.
  
  Enzymes
- E.
  
  Carrier proteins
3.

Which of the following is not true about Gq-proteins
- A.
  
  Increases DAG
- B.
  
  Increases intracellular Ca+2 ions
- C.
  
  Activates tyrosine kinase C
- D.
  
  Linked to alpha-1 adrenergic receptors
- E.
  
  None of the above
4.

Which of the following is common between between DNA-linked receptors and NO receptors
- A.
  
  They are found inside the cells
- B.
  
  They both act on genetic apparatus
- C.
  
  The action of both of them depends on the formation of a second messenger
- D.
  
  They modify protein production
- E.
  
  All of the above
5.

Which of the following is common between agonists and antagonists
- A.
  
  They have the same rate of association and disassociation
- B.
  
  They both have affinity
- C.
  
  They both have efficacy
- D.
  
  Two of the above
6.

Which of the following is used to calculate the effectiveness of the drug in relation to its dose
- A.
  
  Emax
- B.
  
  ED50
- C.
  
  Therapeutic index
- D.
  
  Steepness of slope of the dose-effect graph
- E.
  
  Two of the above
7.

Which of the following parameters can't be obtained from a quantal-dose curve
- A.
  
  Emax
- B.
  
  ED50
- C.
  
  LD50
- D.
  
  Safety index
- E.
  
  None of the above
8.

Which of the following regarding chronopharmacology is not correct?
- A.
  
  Attacks of bronchial asthma are common at night
- B.
  
  Circadian variation of sympathetic activity causes MI in mornings
- C.
  
  Antihistamine treatment should be given at midnight
- D.
  
  Irritant drugs should be given after meals
- E.
  
  None of the above
9.

A child is 5 years old and the dose of a drug he takes is 10mg.Find the adult dose
- A.
  
  34mg
- B.
  
  43mg
- C.
  
  12mg
- D.
  
  51mg
10.

Which of the following drugs needs to be present in order to cause malignant hyperthermia
- A.
  
  Succinylcholine
- B.
  
  Halothane
- C.
  
  Barbiturates
- D.
  
  Sulphonamides
- E.
  
  Succinylcholine and halothane together
11.

Which of the following drugs do not cause porphyrias in a person having genetic defeciency in second enzyme converting porphyrin to heme
- A.
  
  Barbiturates
- B.
  
  Aminoglycosides
- C.
  
  Sulphonamides
- D.
  
  Drugs stimulating ALA synthase
- E.
  
  None of the above
12.

Which of the following drugs cause hemolytic anemia due to G6PD defeciency
- A.
  
  Fava beans
- B.
  
  Antimalarials
- C.
  
  Sulphonamides
- D.
  
  All of the above
13.

The synthesis of which of the following clotting factors is not inhibited by warfarin
- A.
  
  2
- B.
  
  9
- C.
  
  7
- D.
  
  10
- E.
  
  None of the above
14.

Which of the following match in teratogenic drugs is incorrect
- A.
  
  I131-->fetal goiter
- B.
  
  Antiepileptics-->cleft palate
- C.
  
  Thalidomide-->fetal anomalies
- D.
  
  Teracyclins-->dental hypoplasia
15.

Iatrogenic diseases are of which type of adverse reactions
- A.
  
  A
- B.
  
  B
- C.
  
  C
- D.
  
  D
- E.
  
  E
16.

Metronidazole induces which of the following type D reactions
- A.
  
  Carcinogenecity
- B.
  
  Teratogenecity
- C.
  
  Mutagenecity
- D.
  
  All of the above
17.

Drug dependence is of which type of adverse effects
- A.
  
  A
- B.
  
  B
- C.
  
  C
- D.
  
  D
- E.
  
  E
18.

Hypertension adverse effect is caused by which of the following
- A.
  
  Stoppage of clonidine
- B.
  
  Stoppage of B-adrenergic blockers
- C.
  
  Corticosteroids chronic use
- D.
  
  Two of the above
- E.
  
  All of the above
19.

Which of the following effects occur at therapeutic dose
- A.
  
  Side effects
- B.
  
  Seizure due to lidocaine
- C.
  
  Toxic effect
- D.
  
  Intolerance
- E.
  
  Two of the above
20.

Oral anticoagulants cause which of the following
- A.
  
  Hepatotoxicity
- B.
  
  Analgesic nephropathy
- C.
  
  Addisonian crisis on stoppage
- D.
  
  Thromboembolism
- E.
  
  None of the above
21.

Which of the following relating to methods of drug transport is incorrect
- A.
  
  Facilitated diffusion involves transport of substances across ion channels
- B.
  
  Active transport moves substances against concentration gradient
- C.
  
  Pinocytosis uses energy
- D.
  
  Carrier mediated transport is subjected to saturation and competition
- E.
  
  None of the above
22.

Which of the following is incorrect about transport factors related to drugs
- A.
  
  Inorganic substanes are better absorbed than organic
- B.
  
  Solutions are better absorbed than suspensions
- C.
  
  More lipid soluble drugs are absorbed better than less lipid soluble ones(provided both have same solubility for water)
- D.
  
  Ferric is better absorbed than ferrous
- E.
  
  None of the above
23.

A drug of weak basicity has a pKa of 3 and the ratio of unionized base to ionized base is 2:3.Find the pH of the medium containing the drug(correct to 2 decimal places)
- A.
  
  2.82
- B.
  
  3.18
- C.
  
  4.02
- D.
  
  2.37
24.

Which of the following body mechanisms is most useful in toxicity treatment of drugs with high pKa in the urine
- A.
  
  Increasing pH of the urine
- B.
  
  Decreasing pH of the urine
- C.
  
  Increasing pH of plasma filtered
- D.
  
  Decreasing pH of plasma filtered
25.

Which of the following drugs is most absorbed by the stomach
- A.
  
  Acidic drug
- B.
  
  Basic drug
- C.
  
  Neutral drug
- D.
  
  All have the same absorbance