Medicinal Chemistry Drug Metabolism/ Cyp 450 System
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Medicinal Chemistry quiz on Drug Metabolism and the CYP 450 System.
- 1.What is the site first-pass metabolism before molecules reach systemic circulation?
- A.
Kidney
- B.
Throat
- C.
Liver
- D.
Intestine
- E.
Urinary tract
- 2.What plays a major role in extra-hepatic metabolism and contains CYP3A4 isozyme and P-glycoprotein?
- A.
Kidney
- B.
Throat
- C.
Liver
- D.
Intestine
- E.
Urinary tract
- 3.What test uses microsomal extracts from the ER for in-vitro drug metabolism studies?
- A.
Ames test
- B.
Biochemical tests
- C.
Serology
- D.
Polymorphisms
- E.
None of the above
- 4.Which of the following are protein components of the cytochrome P450 system?
- A.
Heme protein CYP450
- B.
NADH-CYP450 reductase
- C.
NADPH-CYP450 reductase
- D.
A and B
- E.
A and C
- 5.What is not a xenobiotic?
- A.
Plant toxins
- B.
Drugs
- C.
Steroids
- D.
Environmental pollutants
- E.
Carcinogens
- 6.What cytochrome P450 isozyme is most abundantly expressed in the human liver and intestines?
- A.
CYP1A1
- B.
CYP3A4
- C.
CYP2C9
- D.
CYP2D6
- E.
CYP2E1
- 7.Which of the following is an antiarrhythmic drug that is a calcium channel blocker?
- A.
Lidocaine
- B.
Nitroglycerin
- C.
Nifedipine
- D.
Codeine
- E.
Nabumetone
- 8.What cytochrome P450 has a lower activity towards dextromethorphan in African Americans?
- A.
CYP1A1
- B.
CYP3A4
- C.
CYP2C9
- D.
CYP2D6
- E.
CYP2E1
- 9.What drug should not be given to a patient that is a poor CYP2D6 metabolizer?
- A.
Codeine
- B.
Lidocaine
- C.
Nifedipine
- D.
Nitroglycerin
- E.
Nabumetone
- 10.Which of the following are the main isoforms for the metabolism of phenytoin and S-warfarin?
- A.
CYP3A4 and CYP3A5
- B.
CYP2C9 and CYP2C19
- C.
CYP4F2 and CYP4F3
- D.
CYP2C8 and CYP2C18
- E.
CYP4F11 and CYP4F12
- 11.What metabolizes polycyclic aromatic (PAH) hydrocarbons in burnt meats and cigarette smoke?
- A.
CYP1A1
- B.
CYP2A6
- C.
CYP2C9
- D.
CYP2D6
- E.
CYP2E1
- 12.Peptic ulcers will be cured by omeprazole more often if the patient has what?
- A.
Normal CYP3A4
- B.
Defective CYP2C9
- C.
Normal CYP2C9
- D.
Defective CYP2C19
- E.
Normal CYP2C19
- 13.Polymorphisms for alcohol tolerance has not been found for?
- A.
CYP1A1
- B.
CYP2A6
- C.
CYP3A4
- D.
A and B
- E.
A and C
- 14.What leads to differences in Km and Vmax?
- A.
Hydroxylation
- B.
Monooxygenases
- C.
Single nucleotide polymorphism
- D.
A and B
- E.
A and C
- 15.What injection is administered directly into systemic circulation causing rapid distribution?
- A.
Intramuscular
- B.
Intravenous
- C.
Intracerebral
- D.
Intraspinal
- E.
Subcutaneous
- 16.Where is Protonsil converted to Sulfanilamide?
- A.
Liver
- B.
Gut
- C.
Kidney
- D.
Colon
- E.
None of the above
- 17.Metheneamine is activated where and to form what?
- A.
Low ph of urine to form formaldehye
- B.
High ph of urine to form aminosalicylic acid
- C.
Low ph of urine to form aminosalicylic acid
- D.
High ph of urine to form formaldehye
- E.
None of the above
- 18.What drug has a lack of -COOH limits gastric irritation?
- A.
Codeine
- B.
Lidocaine
- C.
Nifedipine
- D.
Nitroglycerin
- E.
Nabunetone
- 19.What solubility should a topical drug have?
- A.
Water insoluble like Methylprednisolone acetate
- B.
Slightly water insolube like Mehtylprednisolone
- C.
Water soluble like Methylprednisolone sodium succinate
- D.
All of the above
- E.
None of the above
- 20.What drug conversion treats psoriasis, has a shorter half-life and is good for pregnant patients?
- A.
Protonsil to Sulfanilamide
- B.
Menadione to Phytonadione
- C.
Olsalazine to mesalamine
- D.
Etretinate to acitretin
- E.
Chloramphenicol palmitate to chloramphenicol
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