Medicinal Chemistry Drug Metabolism/ Cyp 450 System

20 Questions | Total Attempts: 2429

SettingsSettingsSettings
Medicinal Chemistry Drug Metabolism/ Cyp 450 System - Quiz

Medicinal Chemistry quiz on Drug Metabolism and the CYP 450 System.


Questions and Answers
  • 1. 
    What is the site first-pass metabolism before molecules reach systemic circulation?
    • A. 

      Kidney

    • B. 

      Throat

    • C. 

      Liver

    • D. 

      Intestine

    • E. 

      Urinary tract

  • 2. 
    What plays a major role in extra-hepatic metabolism and contains CYP3A4 isozyme and P-glycoprotein?
    • A. 

      Kidney

    • B. 

      Throat

    • C. 

      Liver

    • D. 

      Intestine

    • E. 

      Urinary tract

  • 3. 
    What test uses microsomal extracts from the ER for in-vitro drug metabolism studies?
    • A. 

      Ames test

    • B. 

      Biochemical tests

    • C. 

      Serology

    • D. 

      Polymorphisms

    • E. 

      None of the above

  • 4. 
    Which of the following are protein components of the cytochrome P450 system?
    • A. 

      Heme protein CYP450

    • B. 

      NADH-CYP450 reductase

    • C. 

      NADPH-CYP450 reductase

    • D. 

      A and B

    • E. 

      A and C

  • 5. 
    What is not a xenobiotic?
    • A. 

      Plant toxins

    • B. 

      Drugs

    • C. 

      Steroids

    • D. 

      Environmental pollutants

    • E. 

      Carcinogens

  • 6. 
    What cytochrome P450 isozyme is most abundantly expressed in the human liver and intestines?
    • A. 

      CYP1A1

    • B. 

      CYP3A4

    • C. 

      CYP2C9

    • D. 

      CYP2D6

    • E. 

      CYP2E1

  • 7. 
    Which of the following is an antiarrhythmic drug that is a calcium channel blocker?
    • A. 

      Lidocaine

    • B. 

      Nitroglycerin

    • C. 

      Nifedipine

    • D. 

      Codeine

    • E. 

      Nabumetone

  • 8. 
    What cytochrome P450 has a lower activity towards dextromethorphan in African Americans?
    • A. 

      CYP1A1

    • B. 

      CYP3A4

    • C. 

      CYP2C9

    • D. 

      CYP2D6

    • E. 

      CYP2E1

  • 9. 
    What drug should not be given to a patient that is a poor CYP2D6 metabolizer?
    • A. 

      Codeine

    • B. 

      Lidocaine

    • C. 

      Nifedipine

    • D. 

      Nitroglycerin

    • E. 

      Nabumetone

  • 10. 
    Which of the following are the main isoforms for the metabolism of phenytoin and S-warfarin?
    • A. 

      CYP3A4 and CYP3A5

    • B. 

      CYP2C9 and CYP2C19

    • C. 

      CYP4F2 and CYP4F3

    • D. 

      CYP2C8 and CYP2C18

    • E. 

      CYP4F11 and CYP4F12

  • 11. 
    What metabolizes polycyclic aromatic (PAH) hydrocarbons in burnt meats and cigarette smoke?
    • A. 

      CYP1A1

    • B. 

      CYP2A6

    • C. 

      CYP2C9

    • D. 

      CYP2D6

    • E. 

      CYP2E1

  • 12. 
    Peptic ulcers will be cured by omeprazole more often if the patient has what?
    • A. 

      Normal CYP3A4

    • B. 

      Defective CYP2C9

    • C. 

      Normal CYP2C9

    • D. 

      Defective CYP2C19

    • E. 

      Normal CYP2C19

  • 13. 
    Polymorphisms for alcohol tolerance has not been found for?
    • A. 

      CYP1A1

    • B. 

      CYP2A6

    • C. 

      CYP3A4

    • D. 

      A and B

    • E. 

      A and C

  • 14. 
    What leads to differences in Km and Vmax?
    • A. 

      Hydroxylation

    • B. 

      Monooxygenases

    • C. 

      Single nucleotide polymorphism

    • D. 

      A and B

    • E. 

      A and C

  • 15. 
    What injection is administered directly into systemic circulation causing rapid distribution?
    • A. 

      Intramuscular

    • B. 

      Intravenous

    • C. 

      Intracerebral

    • D. 

      Intraspinal

    • E. 

      Subcutaneous

  • 16. 
    Where is Protonsil converted to Sulfanilamide?
    • A. 

      Liver

    • B. 

      Gut

    • C. 

      Kidney

    • D. 

      Colon

    • E. 

      None of the above

  • 17. 
    Metheneamine is activated where and to form what?
    • A. 

      Low ph of urine to form formaldehye

    • B. 

      High ph of urine to form aminosalicylic acid

    • C. 

      Low ph of urine to form aminosalicylic acid

    • D. 

      High ph of urine to form formaldehye

    • E. 

      None of the above

  • 18. 
    What drug has a lack of -COOH limits gastric irritation?
    • A. 

      Codeine

    • B. 

      Lidocaine

    • C. 

      Nifedipine

    • D. 

      Nitroglycerin

    • E. 

      Nabunetone

  • 19. 
    What solubility should a topical drug have?
    • A. 

      Water insoluble like Methylprednisolone acetate

    • B. 

      Slightly water insolube like Mehtylprednisolone

    • C. 

      Water soluble like Methylprednisolone sodium succinate

    • D. 

      All of the above

    • E. 

      None of the above

  • 20. 
    What drug conversion treats psoriasis, has a shorter half-life and is good for pregnant patients?
    • A. 

      Protonsil to Sulfanilamide

    • B. 

      Menadione to Phytonadione

    • C. 

      Olsalazine to mesalamine

    • D. 

      Etretinate to acitretin

    • E. 

      Chloramphenicol palmitate to chloramphenicol